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Publicaciones científicas

El trabajo del Instituto de Investigaciones Oftalmológicas Ramón Castroviejo está centrado en campo del glaucoma, la isquemia y las enfermedades neurodegenerativas (Alzheimer, ELA, esclerosis múltiple...) y sus efectos en la retina y la visión.

 

The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma.

Ramirez AI, de Hoz R, Salobrar-Garcia E, Salazar JJ, Rojas B, Ajoy D, López-Cuenca I, Rojas P, Triviño A, Ramírez JM.

Front Aging Neurosci. 2017 Jul 6;9:214. doi: 10.3389/fnagi.2017.00214. eCollection 2017. Review.

PMID: 28729832
 

[Situs inversus of the optic nerve. A case report].

Lopez-Cuenca I, de Hoz R, Salobrar-Garcia E, Rojas B, Ramirez AI, Salazar JJ, Trivino A, RamirezJM.

Rev Neurol. 2017 Jun 1;64(11):509-513. Spanish.

PMID: 28555457
 
Goniodysgenesis variability and activity of CYP1B1 genotypes in primary congenital glaucoma.

García-Antón MT, Salazar JJ, de Hoz R, Rojas B, Ramírez AI, Triviño A, Aroca-Aguilar JD, García-Feijoo J, Escribano J, Ramírez JM.

PLoS One. 2017 Apr 27;12(4):e0176386. doi: 10.1371/journal.pone.0176386. eCollection 2017.

PMID: 28448622

The Impact of the Eye in Dementia: The Eye and its Role in Diagnosis and Follow‐up.

Salobrar‐García E, Ramírez AI, de Hoz R, Rojas P, Salazar JJ, Rojas B, Yubero R, Gil P, Triviño A and Ramírez JM.

Update on Dementia 2016 Dr. Davide Moretti (Ed.), InTech, DOI: 10.5772/64490.

Available from: http://www.intechopen.com/books/update-on-dementia/the-impact-of-the-eye-in-dementia-the-eye-and-its-role-in-diagnosis-and-follow-up

Retinal Macroglial Responses in Health and Disease.

de Hoz R, Rojas B, Ramírez AI, Salazar JJ, Gallego BI, Triviño A, Ramírez JM.

Biomed Res Int. 2016;2016:2954721. doi: 10.1155/2016/2954721. Review.

PMID:27294114

Neuroprotective Effects of Low-Dose Statins in the Retinal Ultrastructure of Hypercholesterolemic Rabbits.

Fernández-Navarro J, Aldea P, de Hoz R, Salazar JJ, Ramírez AI, Rojas B, Gallego BI, Triviño A, Tejerina T, Ramírez JM.

PLoS One. 2016 May 4;11(5):e0154800. doi: 10.1371/journal.pone.0154800.

PMID: 27144842

Automatic Counting of Microglial Cells in Healthy and Glaucomatous Mouse Retinas.

de Gracia P, Gallego BI, Rojas B, Ramírez AI, de Hoz R, Salazar JJ, Triviño A, Ramírez JM.

PLoS One. 2015 Nov 18;10(11):e0143278. doi: 10.1371/journal.pone.0143278.

PMID: 26580208

Analysis of Retinal Peripapillary Segmentation in Early Alzheimer's Disease Patients.

Salobrar-Garcia E, Hoyas I, Leal M, de Hoz R, Rojas B, Ramirez AI, Salazar JJ, Yubero R, Gil P, Triviño A, Ramirez JM.

Biomed Res Int. 2015;2015:636548. doi: 10.1155/2015/636548.

PMID: 26557684

Macro- and microglial responses in the fellow eyes contralateral to glaucomatous eyes.

Ramírez AI, Salazar JJ, de Hoz R, Rojas B, Gallego BI, Salobrar-García E, Valiente-Soriano FJ, Triviño A, Ramirez JM.

Prog Brain Res. 2015;220:155-72. doi: 10.1016/bs.pbr.2015.05.003. Review.

PMID: 26497789

Ophthalmologic Psychophysical Tests Support OCT Findings in Mild Alzheimer's Disease.

Salobrar-Garcia E, de Hoz R, Rojas B, Ramirez AI, Salazar JJ, Yubero R, Gil P, Triviño A, Ramirez JM.

J Ophthalmol. 2015;2015:736949. doi: 10.1155/2015/736949.

PMID: 26106485

Novel biodegradable polyesteramide microspheres for controlled drug delivery in Ophthalmology.

Andrés-Guerrero V, Zong M, Ramsay E, Rojas B, Sarkhel S, Gallego B, de Hoz R, Ramírez AI, Salazar JJ, Triviño A, Ramírez JM, Del Amo EM, Cameron N, de-Las-Heras B, Urtti A, Mihov G, Dias A, Herrero-Vanrell R.J Control Release. 2015 Aug 10;211:105-17. doi: 10.1016/j.jconrel.2015.05.279.PMID: 26003040

Morphologic differences observed by scanning electron microscopy according to the reason for pseudophakic IOL explantation.

Fernández-Buenaga R, Alio JL, Ramírez JM, Salazar JJ, Prause JU, Ramírez AI, De Hoz R, Rojas B, Triviño A.

Eur J Ophthalmol. 2015 Sep-Oct;25(5):426-30. doi: 10.5301/ejo.5000615.

PMID: 25952712

Microglia in mouse retina contralateral to experimental glaucoma exhibit multiple signs of activation in all retinal layers.

Rojas B, Gallego BI, Ramírez AI, Salazar JJ, de Hoz R, Valiente-Soriano FJ, Avilés-Trigueros M, Villegas-Perez MP, Vidal-Sanz M, Triviño A, Ramírez JM.

J Neuroinflammation. 2014 Jul 26;11:133. doi: 10.1186/1742-2094-11-133.

PMID: 25064005

Macular thickness as a potential biomarker of mild Alzheimer's disease.

Garcia-Martin ES, Rojas B, Ramirez AI, de Hoz R, Salazar JJ, Yubero R, Gil P, Triviño A, Ramirez JM.

Ophthalmology. 2014 May;121(5):1149-1151.e3. doi: 10.1016/j.ophtha.2013.12.023. No abstract available.

PMID: 24656417

Rod-like microglia are restricted to eyes with laser-induced ocular hypertension but absent from the microglial changes in the contralateral untreated eye.

de Hoz R, Gallego BI, Ramírez AI, Rojas B, Salazar JJ, Valiente-Soriano FJ, Avilés-Trigueros M, Villegas-Perez MP, Vidal-Sanz M, Triviño A, Ramírez JM.

PLoS One. 2013 Dec 18;8(12):e83733. doi: 10.1371/journal.pone.0083733.

PMID: 24367610

IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma.

Gallego BI, Salazar JJ, de Hoz R, Rojas B, Ramírez AI, Salinas-Navarro M, Ortín-Martínez A, Valiente-Soriano FJ, Avilés-Trigueros M, Villegas-Perez MP, Vidal-Sanz M, Triviño A, Ramírez JM.

J Neuroinflammation. 2012 May 14;9:92. doi: 10.1186/1742-2094-9-92.

PMID: 22583833

Quantification of the effect of different levels of IOP in the astroglia of the rat retina ipsilateral and contralateral to experimental glaucoma.

Ramírez AI, Salazar JJ, de Hoz R, Rojas B, Gallego BI, Salinas-Navarro M, Alarcón-Martínez L, Ortín-Martínez A, Avilés-Trigueros M, Vidal-Sanz M, Triviño A, Ramírez JM.

Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5690-6. doi: 10.1167/iovs.10-5248.

PMID: 20538983

Low-dosage statins reduce choroidal damage in hypercholesterolemic rabbits.

Rojas B, Ramírez AI, Salazar JJ, de Hoz R, Redondo A, Raposo R, Mendez T, Tejerina T, Triviño A, Ramírez JM.

Acta Ophthalmol. 2011 Nov;89(7):660-9. doi: 10.1111/j.1755-3768.2009.01829.x.

PMID: 20064114

Substance P and calcitonin gene-related peptide intrinsic choroidal neurons in human choroidal whole-mounts.

de Hoz R, Ramírez AI, Salazar JJ, Rojas B, Ramírez JM, Triviño A.

Histol Histopathol. 2008 Oct;23(10):1249-58. doi: 10.14670/HH-23.1249.

PMID: 18712677

Vimentin isoform expression in the human retina characterized with the monoclonal antibody 3CB2.

Pérez-Alvarez MJ, Isiegas C, Santano C, Salazar JJ, Ramírez AI, Triviño A, Ramírez JM, Albar JP, de la Rosa EJ, Prada C.

J Neurosci Res. 2008 Jun;86(8):1871-83. doi: 10.1002/jnr.21623.

PMID: 18241054

Alterations in the choroid in hypercholesterolemic rabbits: reversibility after normalization of cholesterol levels.

Salazar JJ, Ramírez AI, de Hoz R, Rojas B, Ruiz E, Tejerina T, Triviño A, Ramírez JM.

Exp Eye Res. 2007 Mar;84(3):412-22.

PMID: 17178413

Macroglial and retinal changes in hypercholesterolemic rabbits after normalization of cholesterol levels.

Ramírez AI, Salazar JJ, De Hoz R, Rojas B, Ruiz E, Tejerina T, Ramírez JM, Triviño A.

Exp Eye Res. 2006 Dec;83(6):1423-38.

PMID: 17007836

A comparative study of choroidal innervation in the human and the rabbit (oryctolagus cuniculus).

de Hoz R, Salazar JJ, Ramírez AI, Rojas B, Triviño A, Ramírez JM.

Arch Soc Esp Oftalmol. 2006 Aug;81(8):463-70. Spanish.

PMID:16933170

A cholesterol-enriched diet induces ultrastructural changes in retinal and macroglial rabbit cells.

Triviño A, Ramírez AI, Salazar JJ, de Hoz R, Rojas B, Padilla E, Tejerina T, Ramírez JM.

Exp Eye Res. 2006 Aug;83(2):357-66.

PMID: 16580665

Structural changes of the anterior chamber angle in primary congenital glaucoma with respect to normal development.

Rojas B, Ramírez AI, de-Hoz R, Salazar JJ, Remírez JM, Triviño A.

Arch Soc Esp Oftalmol. 2006 Feb;81(2):65-71. Spanish.

PMID: 16511712

NPY and TH innervation in human choroidal whole-mounts.

Triviño A, de Hoz R, Rojas B, Salazar JJ, Ramirez AI, Ramirez JM.

Histol Histopathol. 2005 Apr;20(2):393-402.

PMID: 15736042

Schlemm's canal and the collector channels at different developmental stages in the human eye.

Ramírez JM, Ramírez AI, Salazar JJ, Rojas B, De Hoz R, Triviño A.

Cells Tissues Organs. 2004;178(3):180-5.

PMID: 15655335

Calcium dobesilate attenuates vascular injury and the progression of diabetic retinopathy in streptozotocin-induced diabetic rats.

Padilla E, Ganado P, Sanz M, Zeini M, Ruiz E, Triviño A, Ramírez AI, Salazar JJ, Ramírez JM, Rojas B, Hoz Rd, Tejerina T.

Diabetes Metab Res Rev. 2005 Mar-Apr;21(2):132-42.

PMID: 15386814

A direct contact between astrocyte and vitreous body is possible in the rabbit eye due to discontinuities in the basement membrane of the retinal inner limiting membrane.

Haddad A, Salazar JJ, Laicine EM, Ramírez AI, Ramírez JM, Triviño A.

Braz J Med Biol Res. 2003 Feb;36(2):207-11.

PMID: 12563522

Distribution and organization of the nerve fiber and ganglion cells of the human choroid.

Triviño A, De Hoz R, Salazar JJ, Ramírez AI, Rojas B, Ramírez JM.

Anat Embryol (Berl). 2002 Oct;205(5-6):417-30.

PMID: 12382145

Changes of astrocytes in retinal ageing and age-related macular degeneration.

Ramírez JM, Ramírez AI, Salazar JJ, de Hoz R, Triviño A.

Exp Eye Res. 2001 Nov;73(5):601-15.

PMID: 11747361

A practical method for the radioisotope labeling of rabbit astrocytes with (3)H-thymidine.

Haddad A, Salazar JJ, Laicine EM, Ramírez AI, Triviño A, Ramírez JM.

J Neurosci Methods. 2001 Nov 15;112(1):51-6.

PMID: 11640957

Application of confocal microscopy in the study of the relationships between astrocytes and blood vessels in the retina.

Ramírez AI, Salazar JJ, Haddad A, Laicine EM, Ramírez JM, Triviño A.

Arch Soc Esp Oftalmol. 2001 Jul;76(7):409-16. Spanish.

PMID: 11438877

Immunohistochemistry in association with scanning electron microscopy for the morphological characterization and location of astrocytes of the rabbit retina.

Haddad A, Ramírez AI, Laicine EM, Salazar JJ, Triviño A, Ramírez JM.

J Neurosci Methods. 2001 Apr 30;106(2):131-7.

PMID: 11325432

Apoptosis in ischemic optic neuropathy.

Salazar JJ, Ramírez AI, de Hoz R, Rojas B, Triviño A, Ramírez JM.

Arch Soc Esp Oftalmol. 2000 Dec;75(12):819-24. Spanish.

PMID: 11151279

Human retinal astroglia. A comparative study of adult and the 18 month postnatal developmental stage.

Triviño A, Ramírez JM, Salazar JJ, Ramírez AI.

J Anat. 2000 Jan;196 ( Pt 1):61-70.

PMID: 10697289

Immunohistochemical study of rabbit choroidal innervation.

Ramírez JM, Triviño A, De Hoz R, Ramírez AI, Salazar JJ, García-Sánchez J.

Vision Res. 1999 Apr;39(7):1249-62.

PMID: 10343839

Comparative study of astrocytes in human and rabbit retinae.

Triviño A, Ramírez JM, Ramírez AI, Salazar JJ, García-Sanchez J.

Vision Res. 1997 Jul;37(13):1707-11.

PMID: 9274757

Structural specializations of human retinal glial cells.

Ramírez JM, Triviño A, Ramírez AI, Salazar JJ, García-Sánchez J.

Vision Res. 1996 Jul;36(14):2029-36.

PMID: 8776469

Immunohistochemical study of human optic nerve head astroglia.

Triviño A, Ramírez JM, Salazar JJ, Ramírez AI, García-Sánchez J.

Vision Res. 1996 Jul;36(14):2015-28.

PMID: 8776468

Immunohistochemical study of human retinal astroglia.

Ramirez JM, Triviño A, Ramirez AI, Salazar JJ, Garcia-Sanchez J.

Vision Res. 1994 Aug;34(15):1935-46.

PMID: 7941395

Retinal perivascular astroglia: an immunoperoxidase study.

Triviño A, Ramírez JM, Ramírez AI, Salazar JJ, García-Sanchez J.

Vision Res. 1992 Sep;32(9):1601-7.

PMID: 1455732

Experimental glaucoma significantly decreases atrial natriuretic factor (ANF) receptors in the ciliary processes of the rabbit eye.

Fernandez-Durango R, Ramirez JM, Trivino A, Sanchez D, Paraiso P, Garcia De Lacoba M, Ramirez A, Salazar JJ, Fernandez-Cruz A, Gutkowska J.

Exp Eye Res. 1991 Nov;53(5):591-6.

PMID: 1660404

Existence of atrial natriuretic peptide in choroid, retina and ciliary body in rabbits.

García de Lacoba M, Fernández-Durango R, Triviño A, Ramírez JM, Ramírez AI, Salazar JJ, Fernández-Cruz A, Gutkowska J.

Rev Esp Fisiol. 1991 Jun;47(2):91-6. Spanish.

PMID: 1833802

Immunoreactive atrial natriuretic factor in aqueous humor: its concentration is increased with high intraocular pressure in rabbit eyes.

Fernandez-Durango R, Triviño A, Ramirez JM, Garcia de Lacoba M, Ramirez A, Salazar JJ, Fernandez-Cruz A, Gutkowska J.

Vision Res. 1990;30(9):1305-10.

PMID: 2145692