Actividad Investigadora
PUBLICACIONES 2022:
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The neurovascular unit and systemic biology in stroke - implications for translation and treatment Steffen Tiedt, Alastair M Buchan, Martin Dichgans, Ignacio Lizasoain, Maria A Moro, Eng H Lo 10Nat Rev Neurol 2022 Sep 9 doi: 10.1038/s41582-022-00703-z. Online ahead of print |
Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosaAlonso Sánchez-Cruz, Alberto Hernández-Pinto, Concepción Lillo, Carolina Isiegas, Miguel Marchena, Ignacio Lizasoain, Fátima Bosch, Pedro de la Villa, Catalina Hernández-Sánchez y Enrique J de la Rosa.
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Neutrophil Extracellular Trap Targeting Protects Against Ischemic Damage After Fibrin-Rich Thrombotic Stroke Despite Non-Reperfusion Front Immunol 2022 Feb 16;13:790002. doi: 10.3389/fimmu.2022.790002. eCollection 2022 |
First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteersMacarena Hernández-Jiménez, Samuel Martín-Vílchez, Dolores Ochoa, Gina Mejía-Abril, Manuel Román, Paola Camargo-Mamani, Sergio Luquero-Bueno, Bernd Jilma, María A Moro, Gerónimo Fernández, David Piñeiro, Marc Ribó, Víctor M González, Ignacio Lizasoain y Francisco Abad-Santos.Mol Ther Nucleic Acids 2022 Mar 9;28:124-135. doi: 10.1016/j.omtn.2022.03.005. eCollection 2022 Jun 14 |
Cav-1 Protein Levels in Serum and Infarcted Brain Correlate with Hemorrhagic Volume in a Mouse Model of Thromboembolic Stroke, Independently of rt-PA AdministrationCarme Gubern-Mérida, Pau Comajoan, Gemma Huguet, Isaac García-Yebenes, Ignacio Lizasoain, María Angeles Moro, Irene Puig-Parnau, Juan Manuel Sánchez, Joaquín Serena, Elisabet Kádár, Mar Castellanos. Mol Neurobiol 2022 Feb;59(2):1320-1332. doi: 10.1007/s12035-021-02644-y. Epub 2022 Jan 5 |
Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice
Aníbal Sánchez-de la Torre, Tania Aguado, Alba Huerga-Gómez, Silvia Santamaría, Antonietta Gentile, Juan Carlos Chara, Carlos Matute, Krisztina Monory, Susana Mato, Manuel Guzmán, Beat Lutz, Ismael Galve-Roperh, Javier Palazuelos. Cell Death Dis 2022 Jul 7;13(7):585. doi: 10.1038/s41419-022-05032-z |
New Statement about NRF2 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Isabel Lastres-Becker, Eva de Lago, Ana Martínez, Javier Fernández-Ruiz. Biomolecules 2022 Aug 29;12(9):1200. doi: 10.3390/biom12091200 |
Preclinical investigation of β-caryophyllene as a therapeutic agent in an experimental murine model of Dravet syndromeCristina Alonso, Valentina Satta, Paula Díez-Gutiérrez, Javier Fernández-Ruiz, Onintza Sagredo.Neuropharmacology 2022 Mar 1;205:108914. doi: 10.1016/j.neuropharm.2021.108914 |
The effects of mango leaf extract during adolescence and adulthood in a rat model of schizophrenia Jose Antonio García-Partida, Sonia Torres-Sánchez, Karina MacDowell, Maria Teresa Fernández-Ponce, Lourdes Casas, Casimiro Mantell, María Luisa Soto-Montenegro, Diego Romero-Miguel, Nicolás Lamanna-Rama, Juan Carlos Leza, Manuel Desco, Esther Berrocoso.Front Pharmacol 2022 Jul 26;13:886514. doi: 10.3389/fphar.2022.886514. eCollection 2022 |
The role of BDNF and NGF plasma levels in first-episode schizophrenia: A longitudinal studyAlbert Martínez-Pinteño, Gisela Mezquida, Miquel Bioque, Jose M López-Ilundain, Álvaro Andreu-Bernabeu, Iñaki Zorrilla, Anna Mané, Roberto Rodríguez-Jiménez, Iluminada Corripio, Salvador Sarró, Ángela Ibáñez, Judith Usall, Olga Rivero, Patricia Gassó, Juan Carlos Leza, Manuel J Cuesta, Mara Parellada, Ana González-Pinto, Esther Berrocoso, Sergi Mas, Miguel Bernardo, 2EPs Group |
Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stressDavid Martín-Hernández, Irene L Gutiérrez, Marta González-Prieto, Karina S MacDowell, Javier Robledo-Montaña, Hiram Tendilla-Beltrán, Natalia Calleja-Rodríguez, Álvaro G Bris, Cristina Ulecia-Morón, Beatriz Moreno, Javier R Caso, Borja García-Bueno, Sandra Rodrigues-Mascarenhas, Ignacio Marín-Jiménez, Juan Carlos Leza, Luis Menchén. Sci Rep 2022 Mar 8;12(1):4073. doi: 10.1038/s41598-022-08011-8 |
Endocannabinoid signaling in glioma Carlos Costas-Insua, Manuel Guzmán. Glia 2022 Mar 24. doi: 10.1002/glia.24173. Online ahead of print |
Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61-8048 after chronic intermittent ethanol in mice
Leticia Gil de Biedma-Elduayen, Pablo Giménez-Gómez, Nuria Morales-Puerto, Rebeca Vidal, Carlos Núñez-de la Calle, María Dolores Gutiérrez-López, Esther O'Shea, María Isabel Colado Br J Pharmacol 2022 Jul;179(14):3711-3726. doi: 10.1111/bph.15825. Epub 2022 Mar 7 |
Nucleobase-Derived Nitrones: Synthesis and Antioxidant and Neuroprotective Activities in an In Vitro Model of Ischemia-Reperfusion
Beatriz Chamorro, Iwona E Głowacka, Joanna Gotkowska, Rafał Gulej, Dimitra Hadjipavlou-Litina, Francisco López-Múñoz, José Marco-Contelles, Dorota G Piotrowska, María Jesús Oset-Gasque. Int J Mol Sci 2022 Mar 21;23(6):3411. doi: 10.3390/ijms23063411 |
New Trends in Aging Drug Discovery Bellinda Benhamú, Mar Martín-Fontecha, Henar Vázquez-Villa, María L López-Rodríguez, Silvia Ortega-Gutiérrez. |
The cannabinoid WIN55212-2 suppresses effector T-cell responses and promotes regulatory T cells in human tonsilsAlba Angelina, Mario Pérez-Diego, Angel Maldonado, Beate Rückert, Mübeccel Akdis, Mar Martín-Fontecha, Cezmi A Akdis, Oscar Palomares.
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Cannabinoids induce functional Tregs by promoting tolerogenic DCs via autophagy and metabolic reprograming
Alba Angelina, Mario Pérez-Diego, Jacobo López-Abente, Beate Rückert, Ivan Nombela, Mübeccel Akdis, Mar Martín-Fontecha, Cezmi Akdis, Oscar Palomares. Mucosal Immunol 2022 Jan;15(1):96-108. doi: 10.1038/s41385-021-00455-x. Epub 2021 Sep 21 |
Alba Angelina, Rodrigo Jiménez-Saiz, Mario Pérez-Diego, Angel Maldonado, Beate Rückert, Mübeccel Akdis, Mar Martín-Fontecha, Cezmi A Akdis, Oscar Palomares. |
José M Andreu, Sonia Huecas, Lidia Araújo-Bazán, Henar Vázquez-Villa, Mar Martín-Fontecha. |
Fingolimod Does Not Reduce Infarction After Focal Cerebral Ischemia in Mice During Active or Inactive Circadian PhasesEmiri T Mandeville, Wenlu Li, David Quinto-Alemany, Fang Zhang, Elga Esposito, Takafumi Nakano, Joseph B Mandeville, Janice Lee , Ji Hyun Park, Ken Arai, Christian Waeber, Ignacio Lizasoain, María Ángeles Moro , Eng H Lo Stroke 2022 Oct 12. doi: 10.1161/STROKEAHA.122.039932 |
Diurnal Differences in Immune Response in Brain, Blood and Spleen After Focal Cerebral Ischemia in MiceElga Esposito, Fang Zhang , Ji-Hyun Park, Emiri T Mandeville, Wenlu Li, María Isabel Cuartero, Ignacio Lizasoaín, María A Moro, Eng H Lo Stroke 2022 Dec;53(12):e507-e511
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The strigolactone receptor D14 targets SMAX1 for degradation in response to GR24 treatment and osmotic stressQingtian Li, Elena Sánchez Martín-Fontecha, Aashima Khosla, Alexandra R F White, Sunhyun Chang, Pilar Cubas y David C Nelson. Plant Commun 2022 Jan 31;3(2):100303. doi: 10.1016/j.xplc.2022.100303. eCollection 2022 Mar 14 |
Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity"Juan M Decara, Henar Vázquez-Villa, José Brea, Mónica Alonso, Raj Kamal Srivastava, Laura Orio, Francisco Alén, Juan Suárez, Elena Baixeras, Javier García-Cárceles, Andrea Escobar-Peña, Beat Lutz, Ramón Rodríguez, Eva Codesido , F Javier Garcia-Ladona, Teresa A Bennett, Juan A Ballesteros, Jacobo Cruces, María I Loza, Bellinda Benhamú, Fernando Rodríguez de Fonseca y María L López-Rodríguez. J Med Chem 2022 Apr 14;65(7):5449-5461.doi: 10.1021/acs.jmedchem.1c01842. Epub 2022 Mar 29 |
Javier García-Cárceles, Henar Vázquez-Villa, José Brea, David Ladron de Guevara-Miranda, Giovanni Cincilla, Melchor Sánchez-Martínez, Anabel Sánchez-Merino, Sergio Algar, María Teresa de Los Frailes, Richard S Roberts, Juan A Ballesteros , Fernando Rodríguez de Fonseca, Bellinda Benhamú, María I Loza y María L López-Rodríguez. J Med Chem 2022 Sep 22;65(18):12256-12272. doi: 10.1021/acs.jmedchem.2c00949 |
Nora Khiar-Fernández, Debora Zian, Henar Vázquez-Villa, R Fernando Martínez, Andrea Escobar-Peña, Román Foronda-Sainz, Manisha Ray, Maria Puigdomenech-Poch, Giovanni Cincilla, Melchor Sánchez-Martínez, Yasuyuki Kihara, Jerold Chun, Rubén López-Vales, María L López-Rodríguez y Silvia Ortega-Gutiérrez. J Med Chem 2022 Aug 25;65(16):10956-10974. doi: 10.1021/acs.jmedchem.2c00046
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Juan Carlos Gil-Redondo, Jagoba Iturri, Yaiza Trueba, María Benito-León, Raquel Pérez-Sen, Esmerilda G Delicado, José Luis Toca-Herrera, Felipe Ortega Int J Mol Sci 2022 Oct 7;23(19):11927. doi: 10.3390/ijms231911927
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In vitro inhibition of phosphodiesterase type 4 enhances rat corpus cavernosum nerve-mediated relaxation induced by gasotransmittersVítor S Fernandes,
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IQM-PC332, a Novel DREAM Ligand with Antinociceptive Effect on Peripheral Nerve Injury-Induced Pain |
β-Lactam TRPM8 Antagonist RGM8-51 Displays Antinociceptive Activity in Different Animal Models |
Astrogenesis in the murine dentate gyrus is a life-long and dynamic process
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CCL2 Inhibition of Pro-Resolving Mediators Potentiates Neuroinflammation in Astrocytes
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Noradrenaline in Alzheimer's Disease: A New Potential Therapeutic Target
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The effects of mango leaf extract during adolescence and adulthood in a rat model of schizophrenia
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New Statement about NRF2 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
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An optimized MNK1b aptamer, apMNKQ2, and its potential use as a therapeutic agent in breast cancer
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A Dual Role for FADD in Human Precursor T-Cell NeoplasmsInt J Mol Science 2022 Dec 2;23(23):15157. doi: 10.3390/ijms232315157
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Cannabinoid CB1 receptor expression in oligodendrocyte progenitors of the hippocampus revealed by the NG2-EYFP-knockin mouse
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Glycosylation of Epigallocatechin Gallate by Engineered Glycoside Hydrolases from Talaromyces amestolkiae: Potential Antiproliferative and Neuroprotective Effect of These MoleculesAntioxidants (Basel) 2022 Jul 5;11(7):1325. doi: 10.3390/antiox11071325
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Intercellular signaling by ectodomain shedding at the synapse
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ATXN2 intermediate expansions in amyotrophic lateral sclerosis
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Clinical trials in pediatric ALS: a TRICALS feasibility study
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Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2Neuron. 2022 Feb 16;110(4):627-643.e9. doi: 10.1016/j.neuron.2021.11.025. Epub 2021 Dec 17 |
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GRUPOS DE INVESTIGACIÓN
Lineas de investigación de los grupos que forman del Instituto:
“Neurotransmisión mediada por nucleótidos”, María Teresa Miras Portugal
“Farmacología de la neurosecreción y de la neurodegeneración”, Antonio Rodríguez Artalejo
“Enfermedades neurodegenerativas”, Javier Fernández Ruiz
“Implicación de sistemas glutamatérgicos y nitrérgicos en neurosecreción, neurodegeneración y neuroprotección” María Jesús Oset Gasque
“Neurodegeneración asociada a patología cerebrovascular” Ignacio Lizasoain Hernández y María Ángeles Moro
“Señalización celular” Manuel Guzmán Pastor
"Neuropsicofarmacología molecular" Juan Carlos Leza
“Neurobiología del éxtasis” María Isabel Colado Megía
“Aspectos psiquiátricos del consumo de cannabis”, José Antonio Ramos Atance
Para más detalle sobre cada grupo de investigación, hacer click sobre el tema de investigación del grupo.
Instituto Universitario de Investigación en Neuroquímica