The activation of mGluR4 rescues parallel fiber synaptic transmission and LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome

Ricardo Martín, Alberto Samuel Suárez-Pinilla, Nuria García-Font, M Luisa Laguna-Luque, Juan C López-Ramos, María Jesús Oset-Gasque, Agnes Gruart, José M Delgado-García, Magdalena Torres, José Sánchez-Prieto.

Mol Autism 2023 Apr 7;14(1):14. doi: 10.1186/s13229-023-00547-4

Neuroinflammation related to the blood-brain barrier and sphingosine-1-phosphate in a pre-clinical model of periodontal diseases and depression in rats

David Martín-Hernández, María Martínez, Javier Robledo-Montaña, Marina Muñoz-López, Leire Virto, Nagore Ambrosio, Maria José Marín, Eduardo Montero, David Herrera, Mariano Sanz, Juan C Leza, Elena Figuero, Borja García-Bueno.

J Clin Periodontol 2023  May;50(5):642-656. doi: 10.1111/jcpe.13780. Epub 2023 Jan 27

Neuroimaging revealed long-lasting glucose metabolism changes to morphine withdrawal in rats pretreated with the cannabinoid agonist CP-55,940 during periadolescence

N Lamanna-Rama, K S MacDowell, G López, J C Leza, M Desco, E Ambrosio, M L Soto-Montenegro.

Eur Neuropsychopharmacol  2023 Apr;69:60-76. doi: 10.1016/j.euroneuro.2023.01.005. Epub 2023 Feb 11

Thienopyrimidine Derivatives as GPR55 Receptor Antagonists: Insight into Structure-Activity Relationship

Laura Figuerola-Asencio, Paula Morales, Pingwei Zhao, Dow P Hurst, Sommayah S Sayed, Katsuya L Colón, María Gómez-Cañas, Javier Fernández-Ruiz, Mitchell P Croatt, Patricia H Reggio, Mary E Abood, Nadine Jagerovic.

ACS Med Chem Lett  2022 Dec 2;14(1):18-25. doi: 10.1021/acsmedchemlett.2c00325. eCollection 2023 Jan 12

Endocannabinoid-Binding Receptors as Drug Targets

María Gómez-Cañas, Carmen Rodríguez-Cueto, Valentina Satta, Inés Hernández-Fisac, Elisa Navarro, Javier Fernández-Ruiz.

Methods Mol Biol 2023;2576:67-94. doi: 10.1007/978-1-0716-2728-0_6

Retinal Tissue Shows Glial Changes in a Dravet Syndrome Knock-in Mouse Model

Juan J Salazar, Andrea Satriano, José A Matamoros, José A Fernández-Albarral, Elena Salobrar-García, Inés López-Cuenca, Rosa de Hoz, Lidia Sánchez-Puebla, José M Ramírez, Cristina Alonso, Valentina Satta, Inés Hernández-Fisac, Onintza Sagredo, Ana I Ramírez.

Int J Mol Sci 2023 Feb 1;24(3):2727 doi: 10.3390/ijms24032727

Tumor Necrosis Factor (TNF)-α-Stimulated Gene 6 (TSG-6): A Promising Immunomodulatory Target in Acute Neurodegenerative Diseases

Daniele La Russa, Chiara Di Santo, Ignacio Lizasoain, Ana Moraga, Giacinto Bagetta, Diana Amantea.

Int J Mol Sci 2023 Jan 6;24(2):1162. doi: 10.3390/ijms24021162

Beneficial effect of TLR4 blockade by a specific aptamer antagonist after acute myocardial infarction

Marta Paz-García, Adrián Povo-Retana, Rafael I Jaén, Patricia Prieto, Diego A Peraza, Carlos Zaragoza, Macarena Hernandez-Jimenez, David Pineiro, Javier Regadera, María L García-Bermejo, E Macarena Rodríguez-Serrano, Sergio Sánchez-García, María A Moro, Ignacio Lizasoaín, Carmen Delgado, Carmen Valenzuela, Lisardo Boscá.

Biomed Pharmacother 2023 Feb;158:114214. doi: 10.1016/j.biopha.2023.114214. Epub 2023 Jan 4

Comparison of 2 medium cutoff dialyzers versus on-line hemodiafiltration regarding depurative ability and albumin loss: An uncontrolled clinical research

Patricia Martínez-Miguel, Rocío Gimena Muñoz, Marta Barrionuevo González, Susana López-Ongil, María Ángeles Moro, Ignacio Lizasoain, Diego Rodríguez-Puyol, Juan Manuel García Segura.

Artif Organs 2023 Mar;47(3):589-594. doi: 10.1111/aor.14466. Epub 2022 Dec 2

Endocannabinoid signaling in glioma

Carlos Costas-Insua, Manuel Guzmán.

Glia 2023 Jan;71(1):127-138. doi: 10.1002/glia.24173. Epub 2022 Mar 24

Neuroprotective and antioxidant properties of new quinolylnitrones in in vitro and in vivo cerebral ischemia models

Beatriz Chamorro, Sara Izquierdo-Bermejo, Julia Serrano, Dimitra Hadjipavlou-Litina, Mourad Chioua, Francisco López-Muñoz, José Marco-Contelles, Ricardo Martínez-Murillo, María Jesús Oset-Gasque.

 Sci Rep    2023 Feb 17;13(1):2865.   doi: 10.1038/s41598-023-29929-7

Neuroprotective and Antioxidant Properties of CholesteroNitrone ChN2 and QuinolylNitrone QN23 in an Experimental Model of Cerebral Ischemia: Involvement of Necrotic and Apoptotic Cell Death

Beatriz Chamorro, Sara Izquierdo-Bermejo, María Dolores Martín-de-Saavedra, Francisco López-Muñoz, Mourad Chioua, José Marco-Contelles, María Jesús Oset-Gasque.

Antioxidants (Basel)  2023 Jun 29;12(7):1364.  doi: 10.3390/antiox12071364

Fatty acids fuelling astroglia and beyond

Manuel Guzmán

Affiliations expand  PMID: 37460844   DOI: 10.1038/s42255-023-00845-4

Control of a hippocampal recurrent excitatory circuit by cannabinoid receptor-interacting protein Gap43

Irene B Maroto, Carlos Costas-Insua, Coralie Berthoux, Estefanía Moreno, Andrea Ruiz-Calvo, Carlos Montero-Fernández, Andrea Macías-Camero, Ricardo Martín, Nuria García-Font, José Sánchez-Prieto, Giovanni Marsicano, Luigi Bellocchio, Enric I Canela, Vicent Casadó, Ismael Galve-Roperh, Ángel Núñez, David Fernández de Sevilla, Ignacio Rodríguez-Crespo, Pablo E Castillo, Manuel Guzmán.

Nat Commun  2023 Apr 21;14(1):2303   doi: 10.1038/s41467-023-38026-2.

Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer

Isabel Tundidor, Marta Seijo-Vila, Sandra Blasco-Benito, María Rubert-Hernández, Sandra Adámez, Clara Andradas, Sara Manzano, Isabel Álvarez-López, Cristina Sarasqueta, María Villa-Morales, Carmen González-Lois, Esther Ramírez-Medina, Belén Almoguera, Antonio J Sánchez-López, Laura Bindila, Sigrid Hamann, Norbert Arnold, Christoph Röcken, Ignacio Heras-Murillo, David Sancho, Gema Moreno-Bueno, María M Caffarel, Manuel Guzmán, Cristina Sánchez, Eduardo Pérez-Gómez.

Selective inhibition of cannabinoid CB₁ receptor-evoked signalling by the interacting protein GAP43

Irene B Maroto, Estefanía Moreno, Carlos Costas-Insua, Javier Merino-Gracia, Rebeca Diez-Alarcia, Alicia Álvaro-Blázquez, Ángeles Canales, Enric I Canela, Vicent Casadó, Leyre Urigüen, Ignacio Rodríguez-Crespo, Manuel Guzmán.

Neuropharmacology   2023 Sep 7;240:109712.

doi: 10.1016/j.neuropharm.2023.109712. Online ahead of print

Neuronal Cannabinoid CB₁ Receptors Suppress the Growth of Melanoma Brain Metastases by Inhibiting Glutamatergic Signalling

Carlos Costas-Insua, Marta Seijo-Vila, Cristina Blázquez, Sandra Blasco-Benito, Francisco Javier Rodríguez-Baena, Giovanni Marsicano , Eduardo Pérez-Gómez, Cristina Sánchez, Berta Sánchez-Laorden, Manuel Guzmán. 

Cancers (Basel)  2023 Apr 24;15(9):2439. doi: 10.3390/cancers15092439

The GRP78-PERK axis contributes to memory and synaptic impairments in Huntington's disease R6/1 mice

Marc Espina, Nadia Di Franco, Martina Brañas-Navarro, Irene Rodriguez Navarro, Veronica Brito, Laura Lopez-Molina, Carlos Costas-Insua, Manuel Guzmán, Silvia Ginés.

Neurobiol Dis  2023 Aug;184:106225. doi: 10.1016/j.nbd.2023.106225. Epub 2023 Jul 11

Disease-modifying effects of cannabidiol, β-caryophyllene and their combination in Syn1-Cre/Scn1a^WT/A1783V mice, a preclinical model of Dravet syndrome

Cristina Alonso, Valentina Satta, Inés Hernández-Fisac, Javier Fernández-Ruiz, Onintza Sagredo.

Neuropharmacology 2023 Oct 1;237:109602.  doi: 10.1016/j.neuropharm.2023.109602. Epub 2023 Jun 

Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice

Irene Santos-García, Carmen Rodríguez-Cueto, Patricia Villegas, Fabiana Piscitelli, Anna Lauritano, Che-Kun J Shen, Vincenzo Di Marzo, Javier Fernández-Ruiz, Eva de Lago.

J Neuroinflammation 2023 May 6;20(1):108.  doi: 10.1186/s12974-023-02792-z

The role of gut microbiota in cerebrovascular disease and related dementia

María Isabel Cuartero, Alicia García-Culebras, Carmen Nieto-Vaquero, Enrique Fraga, Cristina Torres-López, Jesús Pradillo, Ignacio Lizasoain, María Ángeles Moro.

Br J Pharmacol  2023 Jun 16.  doi: 10.1111/bph.16167. Online ahead of print

Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice

Miguel A Olivencia, Leticia Gil de Biedma-Elduayen, Pablo Giménez-Gómez, Bianca Barreira, Argentina Fernández, Javier Angulo, Maria Isabel Colado, Esther O'Shea, Francisco Perez-Vizcaino.

Br J Pharmacol  2023 Sep;180(18):2361-2376. doi: 10.1111/bph.16087. Epub 2023 May 12

Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets?

Alicia García-Culebras, María Isabel Cuartero, Carolina Peña-Martínez, Ana Moraga, Sandra Vázquez-Reyes, Francisco Javier de Castro-Millán, Marta Cortes-Canteli, Ignacio Lizasoain, María Ángeles Moro.

Br J Pharmacol 2023 Jun 7 doi: 10.1111/bph.16159. Online ahead of print

Tumor Necrosis Factor (TNF)-α-Stimulated Gene 6 (TSG-6): A Promising Immunomodulatory Target in Acute Neurodegenerative Diseases

Daniele La Russa, Chiara Di Santo, Ignacio Lizasoain, Ana Moraga, Giacinto Bagetta, Diana Amantea. 

Int J Mol Sci 2023 Jan 6;24(2):1162. doi: 10.3390/ijms24021162

Consensus Recommendations for Standardized Data Elements, Scales, and Time Segmentations in Studies of Human Circadian/Diurnal Biology and Stroke

Jeffrey L Saver, Elizabeth B Klerman, Alastair M Buchan, Patricia Calleja, Ignacio Lizasoain, Mersedeh Bahr-Hosseini, Sarah Lee, David S Liebeskind, Philipp Mergenthaler, Katherine T Mun, MingMing Ning, David Pelz, David Ray, Peter M Rothwell, Pierre Seners, Anirudh Sreekrishnan, Eleanor Mina Sung , Steffen Tiedt, Alastair J S Webb, Teresa A Wölfer, Gregory W Albers

Stroke  2023 Jul;54(7):1943-1949.

doi: 10.1161/STROKEAHA.122.041394. Epub 2023 Jun 5

Use of Tenecteplase in Acute Ischemic Stroke in the Time of SARS-CoV-2

Fernando Ostos, Alberto Rodríguez-López, Paloma Martin Jiménez, Carmen Sánchez Sánchez, Antonio Martínez-Salio, Federico Ballenilla, Ignacio Lizasoaín, Patricia Calleja-Castaño

Neurohospitalist  2023 Jul;13(3):266-271. doi: 10.1177/19418744231167491. Epub 2023 Apr 14

Defective hippocampal neurogenesis underlies cognitive impairment by carotid stenosis-induced cerebral hypoperfusion in mice

Enrique Fraga, Violeta Medina, María Isabel Cuartero, Alicia García-Culebras, Isabel Bravo-Ferrer, Macarena Hernández-Jiménez, Juan Manuel Garcia-Segura, Olivia Hurtado, Jesus Miguel Pradillo, Ignacio Lizasoain, María Ángeles Moro

Front Cell Neurosci  2023 Aug 11;17:1219847.

doi: 10.3389/fncel.2023.1219847. eCollection 2023