The neurovascular unit and systemic biology in stroke - implications for translation and treatment

Steffen Tiedt, Alastair M Buchan, Martin Dichgans, Ignacio Lizasoain, Maria A Moro, Eng H Lo 10

Nat Rev Neurol  2022 Sep 9   doi: 10.1038/s41582-022-00703-z. Online ahead of print

Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa

Alonso Sánchez-Cruz, Alberto Hernández-Pinto, Concepción Lillo, Carolina Isiegas, Miguel Marchena, Ignacio Lizasoain, Fátima Bosch, Pedro de la Villa, Catalina Hernández-Sánchez y Enrique J de la Rosa.
Front Immunol 2022 Feb 16;13:790002. doi: 10.3389/fimmu.2022.790002. eCollection 2022

Neutrophil Extracellular Trap Targeting Protects Against Ischemic Damage After Fibrin-Rich Thrombotic Stroke Despite Non-Reperfusion
Carolina Peña-Martínez, Violeta Durán-Laforet, Alicia García-Culebras, María Isabel Cuartero, María Ángeles Moro e Ignacio Lizasoain.

Front Immunol 2022 Feb 16;13:790002. doi: 10.3389/fimmu.2022.790002. eCollection 2022

First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers

Cav-1 Protein Levels in Serum and Infarcted Brain Correlate with Hemorrhagic Volume in a Mouse Model of Thromboembolic Stroke, Independently of rt-PA Administration

Carme Gubern-Mérida, Pau Comajoan, Gemma Huguet, Isaac García-Yebenes, Ignacio Lizasoain, María Angeles Moro, Irene Puig-Parnau, Juan Manuel Sánchez, Joaquín Serena, Elisabet Kádár, Mar Castellanos.

Mol Neurobiol  2022 Feb;59(2):1320-1332.  doi: 10.1007/s12035-021-02644-y. Epub 2022 Jan 5

Aníbal Sánchez-de la Torre, Tania Aguado, Alba Huerga-Gómez, Silvia Santamaría, Antonietta Gentile, Juan Carlos Chara, Carlos Matute, Krisztina Monory, Susana Mato, Manuel Guzmán, Beat Lutz, Ismael Galve-Roperh, Javier Palazuelos.

Cell Death Dis 2022 Jul 7;13(7):585. doi: 10.1038/s41419-022-05032-z

New Statement about NRF2 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Isabel Lastres-Becker, Eva de Lago, Ana Martínez, Javier Fernández-Ruiz.

Biomolecules  2022 Aug 29;12(9):1200.  doi: 10.3390/biom12091200

Preclinical investigation of β-caryophyllene as a therapeutic agent in an experimental murine model of Dravet syndrome

The effects of mango leaf extract during adolescence and adulthood in a rat model of schizophrenia

The role of BDNF and NGF plasma levels in first-episode schizophrenia: A longitudinal study

Albert Martínez-Pinteño, Gisela Mezquida, Miquel Bioque, Jose M López-Ilundain, Álvaro Andreu-Bernabeu, Iñaki Zorrilla, Anna Mané, Roberto Rodríguez-Jiménez, Iluminada Corripio, Salvador Sarró, Ángela Ibáñez, Judith Usall, Olga Rivero, Patricia Gassó, Juan Carlos Leza, Manuel J Cuesta, Mara Parellada, Ana González-Pinto, Esther Berrocoso, Sergi Mas, Miguel Bernardo, 2EPs Group
Eur Neuropsychopharmacol 2022 Apr;57:105-117. doi: 10.1016/j.euroneuro.2022.02.003. Epub 2022 Feb 24

Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress

David Martín-Hernández, Irene L Gutiérrez, Marta González-Prieto, Karina S MacDowell, Javier Robledo-Montaña, Hiram Tendilla-Beltrán, Natalia Calleja-Rodríguez, Álvaro G Bris, Cristina Ulecia-Morón, Beatriz Moreno, Javier R Caso, Borja García-Bueno, Sandra Rodrigues-Mascarenhas, Ignacio Marín-Jiménez, Juan Carlos Leza, Luis Menchén.

Sci Rep 2022 Mar 8;12(1):4073. doi: 10.1038/s41598-022-08011-8

Endocannabinoid signaling in glioma

Carlos Costas-Insua, Manuel Guzmán.

Glia 2022 Mar 24. doi: 10.1002/glia.24173. Online ahead of print

Aníbal Sánchez-de la Torre # 1 2 3, Tania Aguado # 1 2 3, Alba Huerga-Gómez 1 2 3, Silvia Santamaría 1 2 3, Antonietta Gentile 4 5, Juan Carlos Chara 2 6 7, Carlos Matute 2 6 7, Krisztina Monory, Susana Mato, Manuel Guzmán.

Cell Death Dis 2022 Jul 7;13(7):585. doi: 10.1038/s41419-022-05032-z

Leticia Gil de Biedma-Elduayen, Pablo Giménez-Gómez, Nuria Morales-Puerto, Rebeca Vidal, Carlos Núñez-de la Calle, María Dolores Gutiérrez-López, Esther O'Shea, María Isabel Colado

Br J Pharmacol 2022 Jul;179(14):3711-3726.
doi: 10.1111/bph.15825. Epub 2022 Mar 7

Beatriz Chamorro, Iwona E Głowacka, Joanna Gotkowska, Rafał Gulej, Dimitra Hadjipavlou-Litina, Francisco López-Múñoz, José Marco-Contelles, Dorota G Piotrowska, María Jesús Oset-Gasque.

Int J Mol Sci 2022 Mar 21;23(6):3411.
doi: 10.3390/ijms23063411

New Trends in Aging Drug Discovery

Bellinda Benhamú, Mar Martín-Fontecha, Henar Vázquez-Villa, María L López-Rodríguez, Silvia Ortega-Gutiérrez.
Biomedicines 2022 Aug 18;10(8):2006. doi: 10.3390/biomedicines10082006

The cannabinoid WIN55212-2 suppresses effector T-cell responses and promotes regulatory T cells in human tonsils

Alba Angelina, Mario Pérez-Diego, Angel Maldonado, Beate Rückert, Mübeccel Akdis, Mar Martín-Fontecha, Cezmi A Akdis, Oscar Palomares.
Allergy 2022 Mar;77(3):1029-1032. doi: 10.1111/all.15160. Epub 2021 Nov 7

Alba Angelina, Mario Pérez-Diego, Jacobo López-Abente, Beate Rückert, Ivan Nombela, Mübeccel Akdis, Mar Martín-Fontecha, Cezmi Akdis, Oscar Palomares.

Mucosal Immunol 2022 Jan;15(1):96-108.  doi: 10.1038/s41385-021-00455-x. Epub 2021 Sep 21

Cannabinoid WIN55212-2 impairs peanut-allergic sensitization and promotes the generation of allergen-specific regulatory T cells

Alba Angelina, Rodrigo Jiménez-Saiz, Mario Pérez-Diego, Angel Maldonado, Beate Rückert, Mübeccel Akdis, Mar Martín-Fontecha, Cezmi A Akdis, Oscar Palomares.
Clin Exp Allergy 2022 Apr;52(4):540-549. doi: 10.1111/cea.14092. Epub 2022 Jan 23

The Search for Antibacterial Inhibitors Targeting Cell Division Protein FtsZ at Its Nucleotide and Allosteric Binding Sites

José M Andreu, Sonia Huecas, Lidia Araújo-Bazán, Henar Vázquez-Villa, Mar Martín-Fontecha.
Biomedicines 2022 Jul 28;10(8):1825.  doi: 10.3390/biomedicines10081825.