Institutos Universitarios

Actividad Investigadora

PUBLICACIONES 2022:

 

The neurovascular unit and systemic biology in stroke - implications for translation and treatment

Steffen Tiedt, Alastair M Buchan, Martin Dichgans, Ignacio Lizasoain, Maria A Moro, Eng H Lo 10

Nat Rev Neurol  2022 Sep 9   doi: 10.1038/s41582-022-00703-z. Online ahead of print

Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa
Alonso Sánchez-Cruz, Alberto Hernández-Pinto, Concepción Lillo, Carolina Isiegas, Miguel Marchena, Ignacio Lizasoain, Fátima Bosch, Pedro de la Villa, Catalina Hernández-Sánchez y Enrique J de la Rosa.
Front Immunol 2022 Feb 16;13:790002. doi: 10.3389/fimmu.2022.790002. eCollection 2022

Neutrophil Extracellular Trap Targeting Protects Against Ischemic Damage After Fibrin-Rich Thrombotic Stroke Despite Non-Reperfusion
Carolina Peña-Martínez, Violeta Durán-Laforet, Alicia García-Culebras, María Isabel Cuartero, María Ángeles Moro e Ignacio Lizasoain.

Front Immunol 2022 Feb 16;13:790002. doi: 10.3389/fimmu.2022.790002. eCollection 2022

First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers
Macarena Hernández-Jiménez, Samuel Martín-Vílchez, Dolores Ochoa, Gina Mejía-Abril, Manuel Román, Paola Camargo-Mamani, Sergio Luquero-Bueno, Bernd Jilma, María A Moro, Gerónimo Fernández, David Piñeiro, Marc Ribó, Víctor M González, Ignacio Lizasoain y Francisco Abad-Santos.
Mol Ther Nucleic Acids 2022 Mar 9;28:124-135. doi: 10.1016/j.omtn.2022.03.005. eCollection 2022 Jun 14
Cav-1 Protein Levels in Serum and Infarcted Brain Correlate with Hemorrhagic Volume in a Mouse Model of Thromboembolic Stroke, Independently of rt-PA Administration

Carme Gubern-Mérida, Pau Comajoan, Gemma Huguet, Isaac García-Yebenes, Ignacio Lizasoain, María Angeles Moro, Irene Puig-Parnau, Juan Manuel Sánchez, Joaquín Serena, Elisabet Kádár, Mar Castellanos.

Mol Neurobiol  2022 Feb;59(2):1320-1332.  doi: 10.1007/s12035-021-02644-y. Epub 2022 Jan 5

Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice

Aníbal Sánchez-de la Torre, Tania Aguado, Alba Huerga-Gómez, Silvia Santamaría, Antonietta Gentile, Juan Carlos Chara, Carlos Matute, Krisztina Monory, Susana Mato, Manuel Guzmán, Beat Lutz, Ismael Galve-Roperh, Javier Palazuelos.

Cell Death Dis 2022 Jul 7;13(7):585. doi: 10.1038/s41419-022-05032-z

New Statement about NRF2 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Isabel Lastres-Becker, Eva de Lago, Ana Martínez, Javier Fernández-Ruiz.

Biomolecules  2022 Aug 29;12(9):1200.  doi: 10.3390/biom12091200

Preclinical investigation of β-caryophyllene as a therapeutic agent in an experimental murine model of Dravet syndrome
Cristina Alonso, Valentina Satta, Paula Díez-Gutiérrez, Javier Fernández-Ruiz, Onintza Sagredo.
Neuropharmacology 2022 Mar 1;205:108914. doi: 10.1016/j.neuropharm.2021.108914

The effects of mango leaf extract during adolescence and adulthood in a rat model of schizophrenia

Jose Antonio García-Partida, Sonia Torres-Sánchez, Karina MacDowell, Maria Teresa Fernández-Ponce, Lourdes Casas, Casimiro Mantell, María Luisa Soto-Montenegro, Diego Romero-Miguel, Nicolás Lamanna-Rama, Juan Carlos Leza, Manuel Desco, Esther Berrocoso.
Front Pharmacol 2022 Jul 26;13:886514. doi: 10.3389/fphar.2022.886514. eCollection 2022
The role of BDNF and NGF plasma levels in first-episode schizophrenia: A longitudinal study

Albert Martínez-Pinteño, Gisela Mezquida, Miquel Bioque, Jose M López-Ilundain, Álvaro Andreu-Bernabeu, Iñaki Zorrilla, Anna Mané, Roberto Rodríguez-Jiménez, Iluminada Corripio, Salvador Sarró, Ángela Ibáñez, Judith Usall, Olga Rivero, Patricia Gassó, Juan Carlos Leza, Manuel J Cuesta, Mara Parellada, Ana González-Pinto, Esther Berrocoso, Sergi Mas, Miguel Bernardo, 2EPs Group
Eur Neuropsychopharmacol 2022 Apr;57:105-117. doi: 10.1016/j.euroneuro.2022.02.003. Epub 2022 Feb 24

Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress

David Martín-Hernández, Irene L Gutiérrez, Marta González-Prieto, Karina S MacDowell, Javier Robledo-Montaña, Hiram Tendilla-Beltrán, Natalia Calleja-Rodríguez, Álvaro G Bris, Cristina Ulecia-Morón, Beatriz Moreno, Javier R Caso, Borja García-Bueno, Sandra Rodrigues-Mascarenhas, Ignacio Marín-Jiménez, Juan Carlos Leza, Luis Menchén.

Sci Rep 2022 Mar 8;12(1):4073. doi: 10.1038/s41598-022-08011-8

Endocannabinoid signaling in glioma

Carlos Costas-Insua, Manuel Guzmán.

Glia 2022 Mar 24. doi: 10.1002/glia.24173. Online ahead of print

Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61-8048 after chronic intermittent ethanol in mice

Leticia Gil de Biedma-Elduayen, Pablo Giménez-Gómez, Nuria Morales-Puerto, Rebeca Vidal, Carlos Núñez-de la Calle, María Dolores Gutiérrez-López, Esther O'Shea, María Isabel Colado

Br J Pharmacol 2022 Jul;179(14):3711-3726. doi: 10.1111/bph.15825. Epub 2022 Mar 7

Nucleobase-Derived Nitrones: Synthesis and Antioxidant and Neuroprotective Activities in an In Vitro Model of Ischemia-Reperfusion

Beatriz Chamorro, Iwona E Głowacka, Joanna Gotkowska, Rafał Gulej, Dimitra Hadjipavlou-Litina, Francisco López-Múñoz, José Marco-Contelles, Dorota G Piotrowska, María Jesús Oset-Gasque.

Int J Mol Sci 2022 Mar 21;23(6):3411. doi: 10.3390/ijms23063411

New Trends in Aging Drug Discovery

Bellinda Benhamú, Mar Martín-Fontecha, Henar Vázquez-Villa, María L López-Rodríguez, Silvia Ortega-Gutiérrez.
Biomedicines 2022 Aug 18;10(8):2006. doi: 10.3390/biomedicines10082006

The cannabinoid WIN55212-2 suppresses effector T-cell responses and promotes regulatory T cells in human tonsils
Alba Angelina, Mario Pérez-Diego, Angel Maldonado, Beate Rückert, Mübeccel Akdis, Mar Martín-Fontecha, Cezmi A Akdis, Oscar Palomares.
Allergy 2022 Mar;77(3):1029-1032. doi: 10.1111/all.15160. Epub 2021 Nov 7
Cannabinoids induce functional Tregs by promoting tolerogenic DCs via autophagy and metabolic reprograming

Alba Angelina, Mario Pérez-Diego, Jacobo López-Abente, Beate Rückert, Ivan Nombela, Mübeccel Akdis, Mar Martín-Fontecha, Cezmi Akdis, Oscar Palomares.

Mucosal Immunol 2022 Jan;15(1):96-108.  doi: 10.1038/s41385-021-00455-x. Epub 2021 Sep 21

Cannabinoid WIN55212-2 impairs peanut-allergic sensitization and promotes the generation of allergen-specific regulatory T cells

Alba Angelina, Rodrigo Jiménez-Saiz, Mario Pérez-Diego, Angel Maldonado, Beate Rückert, Mübeccel Akdis, Mar Martín-Fontecha, Cezmi A Akdis, Oscar Palomares.
Clin Exp Allergy 2022 Apr;52(4):540-549. doi: 10.1111/cea.14092. Epub 2022 Jan 23

The Search for Antibacterial Inhibitors Targeting Cell Division Protein FtsZ at Its Nucleotide and Allosteric Binding Sites

José M Andreu, Sonia Huecas, Lidia Araújo-Bazán, Henar Vázquez-Villa, Mar Martín-Fontecha.
Biomedicines 2022 Jul 28;10(8):1825.  doi: 10.3390/biomedicines10081825.

Fingolimod Does Not Reduce Infarction After Focal Cerebral Ischemia in Mice During Active or Inactive Circadian Phases

Emiri T MandevilleWenlu LiDavid Quinto-AlemanyFang ZhangElga EspositoTakafumi NakanoJoseph B MandevilleJanice Lee Ji Hyun ParkKen AraiChristian WaeberIgnacio LizasoainMaría Ángeles Moro Eng H Lo

Stroke  2022 Oct 12. doi: 10.1161/STROKEAHA.122.039932

Diurnal Differences in Immune Response in Brain, Blood and Spleen After Focal Cerebral Ischemia in Mice

Elga EspositoFang Zhang Ji-Hyun ParkEmiri T MandevilleWenlu LiMaría Isabel CuarteroIgnacio LizasoaínMaría A MoroEng H Lo 

The strigolactone receptor D14 targets SMAX1 for degradation in response to GR24 treatment and osmotic stress

Qingtian LiElena Sánchez Martín-FontechaAashima KhoslaAlexandra R F WhiteSunhyun ChangPilar Cubas y David C Nelson.

Plant Commun   2022 Jan 31;3(2):100303. doi: 10.1016/j.xplc.2022.100303. eCollection 2022 Mar 14

Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity"

Juan M DecaraHenar Vázquez-VillaJosé BreaMónica AlonsoRaj Kamal SrivastavaLaura OrioFrancisco AlénJuan SuárezElena BaixerasJavier García-CárcelesAndrea Escobar-PeñaBeat LutzRamón RodríguezEva Codesido F Javier Garcia-LadonaTeresa A BennettJuan A BallesterosJacobo CrucesMaría I LozaBellinda BenhamúFernando Rodríguez de Fonseca y María L López-Rodríguez.

J Med Chem  2022 Apr 14;65(7):5449-5461.doi: 10.1021/acs.jmedchem.1c01842. Epub 2022 Mar 29

 

2-(Fluoromethoxy)-4'-( S-methanesulfonimidoyl)-1,1'-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson's Disease

Javier García-CárcelesHenar Vázquez-VillaJosé BreaDavid Ladron de Guevara-MirandaGiovanni CincillaMelchor Sánchez-MartínezAnabel Sánchez-MerinoSergio AlgarMaría Teresa de Los FrailesRichard S RobertsJuan A Ballesteros Fernando Rodríguez de FonsecaBellinda BenhamúMaría I Loza y María L López-Rodríguez.

J Med Chem   2022 Sep 22;65(18):12256-12272. doi: 10.1021/acs.jmedchem.2c00949

Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA2), UCM-14216, Ameliorates Spinal Cord Injury in Mice

Nora Khiar-FernándezDebora ZianHenar Vázquez-VillaR Fernando Martínez, Andrea Escobar-PeñaRomán Foronda-SainzManisha RayMaria Puigdomenech-PochGiovanni CincillaMelchor Sánchez-MartínezYasuyuki Kihara, Jerold ChunRubén López-ValesMaría L López-Rodríguez y Silvia Ortega-Gutiérrez.

J Med Chem 2022 Aug 25;65(16):10956-10974.  doi: 10.1021/acs.jmedchem.2c00046

 

Nucleotide-Induced Nanoscale Changes in the Mechanical Properties of Rat Cerebellar Astrocytes: Selective Stimulation and Blocking of the Purinergic Receptor P2X7

Juan Carlos Gil-RedondoJagoba IturriYaiza TruebaMaría Benito-LeónRaquel Pérez-SenEsmerilda G DelicadoJosé Luis Toca-HerreraFelipe Ortega

Int J Mol Sci  2022 Oct 7;23(19):11927. doi: 10.3390/ijms231911927

 

In vitro inhibition of phosphodiesterase type 4 enhances rat corpus cavernosum nerve-mediated relaxation induced by gasotransmitters
Vítor S FernandesMaría Elvira López-OlivaMaría Pilar MartínezÁngel Agis-TorresPaz RecioJorge Navarro-DoradoMaría Victoria BarahonaSara BeneditoDolores PrietoBelén ClimentMedardo Hernández.

 

IQM-PC332, a Novel DREAM Ligand with Antinociceptive Effect on Peripheral Nerve Injury-Induced Pain

β-Lactam TRPM8 Antagonist RGM8-51 Displays Antinociceptive Activity in Different Animal Models

Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis

Astrogenesis in the murine dentate gyrus is a life-long and dynamic process

 

Comparison of 2 medium cutoff dialyzers versus on-line hemodiafiltration regarding depurative ability and albumin loss: An uncontrolled clinical research

 

From the laboratory to the clinic in acute ischaemic stroke. In vitro and in vivo experimental models

 

J M PradilloA García-CulebrasM I CuarteroC Peña-MartínezM A MoroI LizasoainA Moraga.
Rev Neurolog 2022 Nov 1;75(9):283-293. doi: 10.33588/rn.7509.2022268

CCL2 Inhibition of Pro-Resolving Mediators Potentiates Neuroinflammation in Astrocytes

 

Dysfunction of Inflammatory Pathways and Their Relationship With Psychological Factors in Adult Female Patients With Eating Disorders

 

Editorial: Neuroinflammatory and oxidative/nitrosative pathways in neuropsychiatric and neurological diseases and their possible neuropharmacological regulation, volume I

 

Front Pharmacolol 2022 Sep 16;13:1033281

Gut microbiota, innate immune pathways, and inflammatory control mechanisms in patients with major depressive disorder

 

Immune-Inflammatory Biomarkers Predict Cognition and Social Functioning in Patients With Type 2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A 1-Year Follow-Up Study

 

Inflammation biomarkers in suicide attempts and their relation to abuse, global functioning and cognition

 

Lipid nanoparticles for antisense oligonucleotide gene interference into brain border-associated macrophages

 

Noradrenaline in Alzheimer's Disease: A New Potential Therapeutic Target
Int J Mol Science 2022 May 30;23(11):6143. doi: 10.3390/ijms23116143

 

Preclinical animal models of mental illnesses to translate findings from the bench to the bedside: Molecular brain mechanisms and peripheral biomarkers associated to early life stress or immune challenges

 

Reduced glucocorticoid receptor expression in blood mononuclear cells of patients with borderline personality disorder

 

Front Psychiatry 2022 Aug 2;13:951373. doi: 10.3389/fpsyt.2022.951373. eCollection 2022

The effects of mango leaf extract during adolescence and adulthood in a rat model of schizophrenia

 

The Influence of Oxytocin and Prolactin During a First Episode of Psychosis: The Implication of Sex Differences, Clinical Features, and Cognitive Performance

 

The Role of the Oral Microbiota Related to Periodontal Diseases in Anxiety, Mood and Trauma- and Stress-Related Disorders

 

2022 Jan 27;12:814177.
Front Psychiatry  doi: 10.3389/fpsyt.2021.814177. eCollection 2021.

TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy

 

New Statement about NRF2 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

 

BIOMOLECULES 2022 Aug 29;12(9):1200. doi: 10.3390/biom12091200

Discovery of Mitophagy Inhibitors with Therapeutic Potential in Different Familial Amyotrophic Lateral Sclerosis Mutations

 

Int J Mol Science 2022 Oct 21;23(20):12676.  doi: 10.3390/ijms232012676

An optimized MNK1b aptamer, apMNKQ2, and its potential use as a therapeutic agent in breast cancer

 

A Dual Role for FADD in Human Precursor T-Cell Neoplasms
Int J Mol Science 2022 Dec 2;23(23):15157. doi: 10.3390/ijms232315157
Cannabinoid CB1 receptor expression in oligodendrocyte progenitors of the hippocampus revealed by the NG2-EYFP-knockin mouse
Front Neuroanat  2022 Oct 28;16:1030060. doi: 10.3389/fnana.2022.1030060. eCollection 2022

 

Glycosylation of Epigallocatechin Gallate by Engineered Glycoside Hydrolases from Talaromyces amestolkiae: Potential Antiproliferative and Neuroprotective Effect of These Molecules
Antioxidants (Basel) 2022 Jul 5;11(7):1325. doi: 10.3390/antiox11071325

Intercellular signaling by ectodomain shedding at the synapse

 

Trends Neuroscience  2022 Jun;45(6):483-498 doi: 10.1016/j.tins.2022.03.004. Epub 2022 Apr 13

CIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative

 

ATXN2 intermediate expansions in amyotrophic lateral sclerosis

 

Clinical trials in pediatric ALS: a TRICALS feasibility study

 

Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2

Neuron. 2022 Feb 16;110(4):627-643.e9. doi: 10.1016/j.neuron.2021.11.025. Epub 2021 Dec 17

Biosensing Tacrolimus in Human Whole Blood by Using a Drug Receptor Fused to the Emerald Green Fluorescent Protein

 

Anal Chem  2022 Nov 29;94(47):16337-16344. doi: 10.1021/acs.analchem.2c03122. Epub 2022 Nov 16.

The Search for Antibacterial Inhibitors Targeting Cell Division Protein FtsZ at Its Nucleotide and Allosteric Binding Sites

Biomedicines  2022 Jul 28;10(8):1825. doi: 10.3390/biomedicines10081825

 


GRUPOS DE INVESTIGACIÓN

 
Lineas de investigación de los grupos que forman del Instituto:

 

Neurotransmisión mediada por nucleótidos”, María Teresa Miras Portugal

 “Farmacología de la neurosecreción y de la neurodegeneración”, Antonio Rodríguez Artalejo

 “Enfermedades neurodegenerativas”, Javier Fernández Ruiz

Implicación de sistemas glutamatérgicos y nitrérgicos en neurosecreción, neurodegeneración y neuroprotección” María Jesús Oset Gasque

Neurodegeneración asociada a patología cerebrovascular” Ignacio Lizasoain Hernández y María Ángeles Moro

Señalización celular” Manuel Guzmán  Pastor

"Neuropsicofarmacología molecular"    Juan Carlos Leza

 

 “Neurobiología del éxtasis” María Isabel Colado Megía

 “Aspectos psiquiátricos del consumo de cannabis”, José Antonio Ramos Atance

 

Para más detalle sobre cada grupo de investigación, hacer click sobre el tema de investigación del grupo.

Instituto Universitario de Investigación en Neuroquímica