PUBLICACIONES 2016:

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

Alba Jimenez-Pacheco,XMiguel Diaz-Hernandez, Marina Arribas-Blázquez, Amaya Sanz-Rodríguez, Luis A. Olivos-Oré, Antonio R. Artalejo, Mariana Alves, Michael Letavic, M. Teresa Miras-Portugal, Ronan M. Conroy, Norman Delanty, Michael A. Farrell, Donncha F. O’Brien, Anindya Bhattacharya, Tobias Engel y David C. Henshall.

The Journal of Neuroscience, June 1,  2016  36(22):5920 –5932

Cannabinoid–dopamine interactions in the physiology and physiopathology of the basal ganglia

Concepción García, Cristina Palomo-Garo, Yolanda Gómez-Gálvez y Javier Fernández-Ruiz.

Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties

Valeria Deiana, María Gómez-Cañas, M. Ruth Pazos, Javier Fernández-Ruiz, Battistina Asproni, Elena Cichero, Paola Fossa, Eduardo Muñoz, Francesco Deligia, Gabriele Murineddu,

Moisés García-Arencibia y Gerard A. Pinna.

European Journal of Medicinal Chemistry 112 (2016) 66-80

Targeting Cannabinoid CB2 Receptor sin the Central Nervous System.Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

Gemma Navarro, Paula Morales, Carmen Rodríguez-Cueto, Javier Fernández-Ruiz, Nadine Jagerovic y Rafael Franco.

Frontiers in Neuroscience  2016 Sep 13;10:406

Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis

Paula Morales, María Gómez-Cañas, Gemma Navarro, Dow P. Hurst, Francisco J. Carrillo-Salinas, Laura Lagartera, Ruth Pazos, Pilar Goya, Patricia H. Reggio, Carmen Guaza, Rafael Franco, Javier Fernández-Ruiz y Nadine Jagerovic.

DYSREGULATION OF THE ENDOCANNABINOID SIGNALING SYSTEM IN THE CEREBELLUM AND BRAINSTEM IN A TRANSGENIC MOUSE MODEL OF SPINOCEREBELLAR ATAXIA TYPE-3

CARMEN RODRÍGUEZ-CUETO, MARILUZ HERNÁNDEZ-GÁLVEZ,  CECILIA J. HILLARD, PATRICIA MACIEL, LUIS GARCÍA-GARCÍA, SARA VALDEOLIVAS, MIGUEL A. POZO, JOSÉ A. RAMOS,

MARÍA GÓMEZ-RUIZ Y JAVIER FERNÁNDEZ-RUIZ.

NEUROSCIENCE  2016 Dec 17;339:191-20

Targeting the cannabinoid CB2receptor to attenuate the progressionof motor deficits in LRRK2-transgenic mice

Cristina Palomo-Garo, Yolanda Gómez-Gálvez, Concepción García, Javier Fernández-Ruiz.

Pharmacological Research  Volume 110, August 2016, Pages 181-192

Potential of the cannabinoid CB2 receptor as a pharmacological target against inflammation in Parkinson's disease

Yolanda Gómez-Gálvez, Cristina Palomo-Garo, Javier Fernández-Ruiz y Concepción García.

Conversion of Nonproliferating Astrocytes into Neurogenic Neural Stem Cells: Control by FGF2 and Interferon-c

SUSANNE KLEIDERMAN, SIMON GUTBIER, KEMAL UGUR TUFEKCI, FELIPE ORTEGA, JOAO V. SA, ANA P. TEIXEIRA, CATARINA BRITO, ENRICO GLAAB, BENEDIKT BERNINGER, PAULA M. ALVES, MARCEL LEIST.

Stem Cells 2016 Dec;34(12):2861-2874

TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge

Caty Casas, Patrice Codogno, Marcello Pinti, Henri Batoko, María Moran, Tassula Proikas-Cezanne, Fulvio Reggiori, Agnieszka Sirko, María S Soengas, Guillermo Velasco, Frank Lafont, Jon Lanel, Mathias Faurem y Andrea Cossarizzac.

AUTOPHAGY  2016, VOL. 12, NO. 3, 614–617

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

Sonia Hernández-Tiedra, Gemma Fabrias, David Dávila, Iñigo J. Salanueva, Josefina Casas, L. Ruth Montes, Zuriñe Antón, Elena García-Taboada, María Salazar-Roa, Mar Lorente, Jesper Nylandsted, Jane Armstrong, Israel López-Valero, Christopher S. McKee, Ana Serrano-Puebla, Roberto García-López, José González-Martínez, Jose L. Abad, Kentaro Hanada, Patricia Boya, Félix Goñi, Manuel Guzmán, Penny Lovat, Marja Jaatella, Alicia Alonso y Guillermo Velasco.

AUTOPHAGY 2016, VOL. 12, NO. 11, 2213–2229

Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP

Zuriñe Antón, Ane Landajuela, Javier H. Hervás, L. Ruth Montes, Sonia Hernández-Tiedra, Guillermo Velasco, Felix M. Goñi  y Alicia Alonso.

AUTOPHAGY  2016 Dec;12(12):2386-2403

The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3 Pseudokinase

Tatiana Erazo, Mar Lorente, Anna López-Plana, Pau Muñoz-Guardiola, Patricia Fernández-Nogueira, Jose A. García-Martínez, Paloma Bragado, Gemma Fuster, María Salazar, Jordi Espadaler, Javier Hernández-Losa, Jose Ramon Bayascas, Marc Cortal, Laura Vidal, Pedro Gascón, Mariana Gómez-Ferreria, José Alfón, Guillermo Velasco, Carles Domenech y José M. Lizcano.

Clinical Cancer Research  2016 May 15;22(10):2508-19

Anticancer mechanisms of cannabinoids

Velasco, C. Sánchez y M. Guzmán.

Curr Oncol  2016 Mar;23(2):S23-32

The complex relationship of Tribbles pseudokinase 1, PML/RARA and C/EBPα in leukemia: two possible couples but not a trio

Guillermo Velasco

Haematologica  2016 Oct;101(10):1129-1130

Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK

Luigi Bellocchio, Andrea Ruiz-Calvo, Anna Chiarlone, Magali Cabanas, Eva Resel, Jean-René Cazalets, Cristina Blázquez, Yoon H Cho, Ismael Galve-Roperh, Manuel Guzmán.

J Neuroscience  2016 Oct 12;36(41):10611-10624

Chapter 6 Cannabinoids as Regulators of Neural Development and Adult Neurogenesis

Alline C. Campos, Juan Paraíso-Luna, Manoela V. Fogaça, Francisco S. Guimarães e Ismael Galve-Roperh

Lipidomics of Stem Cells pp 117–136

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

Veronica Torrano, Lorea Valcarcel-Jimenez, Ana Rosa Cortazar, Xiaojing Liu, Jelena Urosevic, Mireia Castillo-Martin, Sonia Fernández-Ruiz, Giampaolo Morciano, Alfredo Caro-Maldonado, Marc Guiu, Patricia Zúñiga-García, Mariona Graupera, Anna Bellmunt, Pahini Pandya, Mar Lorente, Natalia Martín-Martín, James David Sutherland, Pilar Sánchez-Mosquera, Laura Bozal-Basterra, Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Antonio Berenguer, Nieves Embade, Aitziber Ugalde-Olano, Isabel Lacasa-Viscasillas, Ana Loizaga-Iriarte, Miguel Unda-Urzaiz, Nikolaus Schultz, Ana María Aransay, Victoria Sanz-Moreno, Rosa Barrio, Guillermo Velasco, Paolo Pinton, Carlos Cordon-Cardo, JasonW. Locasale, Roger R. Gomis y Arkaitz Carracedo.

Nat Cell Biol  2016 Jun;18(6):645-656

MicroRNA let-7d is a target of cannabinoid CB1 receptor and controls cannabinoid signaling

Anna Chiarlone, Christine Börner, Laura Martín-Gómez, Ada Jiménez-González, Adrián García-Concejo, María L García-Bermejo, Mar Lorente, Cristina Blázquez, Elena García-Taboada, Amador de Haro, Elisa Martella, Volker Höllt, Raquel Rodríguez, Ismael Galve-Roperh, Jürgen Kraus y Manuel Guzmán. 

Neuropharmacology  2016 Sep;108:345-52

Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer

Clara Andradas, Sandra Blasco-Benito, Sonia Castillo-Lluva, Patricia Dillenburg-Pilla, Rebeca Diez-Alarcia, Alba Juanes-García, Elena García-Taboada, Rodrigo Hernando-Llorente, Joaquim Soriano, Sigrid Hamann, Antonia Wenners, Ibrahim

Alkatout, Wolfram Klapper, Christoph Rocken, Maret Bauer, Norbert Arnold, Miguel Quintanilla, Diego Megías, Miguel Vicente-Manzanares, Leyre Urigüen, Silvio Gutkind, Manuel Guzmán, Eduardo Pérez-Gómez y Cristina Sánchez.

Oncotarget  2016 Jul 26;7(30):47565-47575

VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington’s disease

Javier Díaz-Alonso, Juan Paraíso-Luna, Carmen Navarrete, Carmen del Río, Irene Cantarero, Belén Palomares, José Aguareles, Javier Fernández-Ruiz, María Luz Bellido, Federica Pollastro, Giovanni Appendino, Marco A. Calzado, Ismael Galve Roperh y Eduardo Muñoz.

Scientific Reports volume 6, Article number: 29789 (2016)

The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways

Carmen del Río, Carmen Navarrete, Juan A. Collado, M. Luz Bellido, María Gómez-Cañas, M. Ruth Pazos, Javier Fernández-Ruiz, Federica Pollastro, Giovanni Appendino, Marco A. Calzado, Irene Cantarero y Eduardo Muñoz.

Bacterial translocation affects intracellular neuroinflammatory pathways in a depression-like model in rats

David Martín-Hernández, Javier R. Caso, Álvaro G. Bris, Sandra R. Maus, José L.M. Madrigal, Borja García-Bueno, Karina S. MacDowell, Luis Alou, Maria Luisa Gómez-Lus y Juan C. Leza.

Neuropharmacology 103 (2016) 122-133

Modulation of the antioxidant nuclear factor (erythroid 2-derived)- like 2 pathway by antidepressants in rats

David Martín-Hernández , Álvaro G. Bris, Karina S. MacDowell, Borja García-Bueno, José L.M. Madrigal, Juan C. Leza y Javier R. Caso.

Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways

Hongtao Guan, Aban Shuaib, David Davila De Leon, Adrienn Angyal, Maria Salazar, Guillermo Velasco, Mike Holcombe, Steven K Dower, Endre Kiss-To.

Scientific Reports  2016 Sep 7;6:32667

Cannabinoid Type-2 Receptor Drives Neurogenesis and Improves Functional Outcome After Stroke

Isabel Bravo-Ferrer, María I. Cuartero, Juan G. Zarruk, Jesús M. Pradillo, Olivia Hurtado, Víctor G. Romera, Javier Díaz-Alonso, Juan M. García-Segura, Manuel Guzmán, Ignacio Lizasoain, Ismael Galve-Roperh y María A. Moro.

Stroke  2017 Jan;48(1):204-212

Identification of Novel GPR55 Modulators Using Cell-Impedance-Based Label-Free Technology

Paula Morales, Lauren S. Whyte, Roberto Chicharro, María Gómez-Cañas, M. Ruth Pazos, Pilar Goya, Andrew J. Irving, Javier Fernández-Ruiz, Ruth A. Ross y Nadine Jagerovic.

Journal of  Medicinal Chemistry  2016 Mar 10;59(5):1840-53

A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington’s disease

Jose Luis López-Sendon Moreno, Juan García Caldentey, Patricia Trigo Cubillo, Carolina Ruiz Romero, Guillermo García Ribas, M. A. Alonso Alonso Arias, María Jesús García de Yébenes, Rosa María Tolón, Ismael Galve-Roperh, Onintza Sagredo, Sara Valdeolivas, Eva Resel, Silvia Ortega-Gutierrez, María Laura García-Bermejo, Javier Fernández Ruiz, Manuel Guzmán y Justo García de Yebenes Prous.

J Neurol (2016) 263:1390–1400 

Biological characterization of PM226, a chromenoisoxazole, as aselective CB2receptor agonist with neuroprotective profile

Gómez-Cañas, P. Morales, L. García-Toscano, C. Navarrete, E. Muñoz, N. Jagerovic, J. Fernández-Ruiz, M. García-Arencibia, M.R. Pazos.

Pharmacological Research 110 (2016) 205–215

Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia

Borja García-Bueno, Patricia Gassó, Karina S. MacDowell, Luis F. Callado, Sergi Mas, Miguel Bernardo, Amalia Lafuente, J. Javier Meana y Juan C. Leza.

J Psychiatry Neurosci 2016 Apr;41(3):E46-55

Cognition and psychopathology in first-episode psychosis: are they related to inflammation?

B. Cabrera, M. Bioque, R. Penadés y A. González-Pinto, M. Parellada, J. Bobes, A. Lobo, B. García Bueno, Juan Carlos Leza y M. Bernardo.

Dysregulated peripheral endocannabinoid system signaling is associated with cognitive deficits in first-episode psychosis

Miquel Bioque, Bibiana Cabrera, Borja García-Bueno, Karina S. Mac-Dowell, Carla Torrent, Pilar A. Saiz, Mara Parellada, Ana González-Pinto, Antonio Lobo, Juan C. Leza y Miguel Bernardo.

Journal of Psychiatric Research 75 (2016) 14-21

Bacterial translocation affects intracellular neuroinflammatory pathways in a depression-like model in rats

David Martín-Hernández, Javier R. Caso, Álvaro G. Bris, Sandra R. Maus, José L.M. Madrigal, Borja García-Bueno, Karina S. MacDowell, Luis Alou, Maria Luisa Gómez-Lus y Juan C. Leza.

Neuropharmacology 103 (2016) 122-133

Modulation of the antioxidant nuclear factor (erythroid 2-derived)-like 2 pathway by antidepressants in rats

David Martín-Hernández, Álvaro G. Bris, Karina S. MacDowell, Borja García-Bueno, José L.M. Madrigal, Juan C. Leza y Javier R. Caso.

Neuropharmacology 103 (2016) 79-91

BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year

Martinez-Cengotitabengoa, K.S. MacDowell, S. Alberich, F.J. Diaz, B. Garcia-Bueno, R. Rodriguez-Jiménez, M. Bioque, E. Berrocoso, M. Parellada, A. Lobo, P.A. Saiz, C. Matute, M. Bernardo, A. Gonzalez-Pinto, J.C. Leza y FLAMM-PEPs.

Schizophrenia Bulletin vol. 42 no. 1 pp. 142–151, 2016

Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research

Michael Maes, Gabriel Nowak, Javier R. Caso, Juan Carlos Leza, Cai Song, Marta Kubera, Hans Klein, Piotr Galecki, Cristiano Noto, Enrico Glaab, Rudi Balling y Michael Berk.

Mol Neurobiol (2016) 53:2927–2935

Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration

Ferrés-Coy, M. Galofré, F. Pilar-Cuéllar, R. Vidal, V. Paz, E. Ruiz-Bronchal, L. Campa, Á. Pazos, J. R. Caso, J. C. Leza, G. Alvarado, A. Montefeltro, E. M. Valdizán, F Artigas y A. Bortolozzi.

Molecular Psychiatry (2016) 21, 328–338

The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease

Gerwyn Morris, Michael Berk, Andre Carvalho, Javier R. Caso, Yolanda Sanz, Ken Walder y Michael Maes.

Mol Neurobiol DOI 10.1007/s12035-016-0004-2

The Role of Microbiota and Intestinal Permeability in the Pathophysiology of Autoimmune and Neuroimmune Processes with an Emphasis on Inflammatory Bowel Disease Type 1 Diabetes and Chronic Fatigue Syndrome

Gerwyn Morris, Michael Berk, André F. Carvalho, Javier R. Caso, Yolanda Sanz y Michael Maes.

Current Pharmaceutical Design  2016  22(40):6058-6075

The Microbiota and GutBrain Axis Contributions to the Immunopathogenesis of Schizophrenia

Javier R. Caso, Vicent Balanzá Martínez, Tomás Palomo y Borja García Bueno.

The Atypical Antipsychotic Paliperidone Regulates Endogenous Antioxidant/Anti-Inflammatory Pathways in Rat Models of Acute and Chronic Restraint Stress

Karina S. MacDowell, Javier R. Caso, David Martín-Hernández, Beatriz M. Moreno, José L. M. Madrigal, Juan A. Micó, Juan C. Leza y Borja García-Bueno.

Neurotherapeutics (2016) 13:833–843

Innate immune receptor Toll-like receptor 4 signalling in neuropsychiatric diseases

García Bueno, J.R. Caso, J.L.M. Madrigal y J.C. Leza.

Neuroscience and Biobehavioral Reviews 64 (2016) 134–147

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke

Samaneh Maysami, Raymond Wong, Jesus M Pradillo, Adam Denes, Hiramani Dhungana, Tarja Malm, Jari Koistinaho, Cyrille Orset, Mahbubur Rahman, Marina Rubio, Markus Schwaninger, Denis Vivien, Philip M Bath, Nancy J Rothwell y Stuart M Allan.

Journal of Cerebral Blood Flow & Metabolism 2016, Vol. 36(3) 596–605

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis

Cyrille Orset, Benoit Haelewyn, Stuart M. Allan, Saema Ansar, Francesco Campos, Tae Hee Cho, Anne Durand, Mohamad El Amki, Marc Fatar, Isaac Garcia-Yébenes, Maxime Gauberti, Saskia Grudzenski, Ignacio Lizasoain, Eng Lo, Richard Macrez, Isabelle Margaill, Samaneh Maysami, Stephen Meairs, Norbert Nighoghossian, Josune Orbe, Jose Antonio Paramo, Jean-Jacques Parienti, Nancy J. Rothwell, Marina Rubio, Christian Waeber, Alan R. Young, Emmanuel Touzé, Denis Vivien.

Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positrón emission tomography

Ana Moraga, Vanessa Gómez-Vallejo, María Isabel Cuartero, Boguslaw Szczupak, Eneko San Sebastián, Irati Markuerkiaga, Jesús M Pradillo, Makoto Higuchi, Jordi Llop, María Ángeles Moro, Abraham Martín e Ignacio Lizasoain.

Journal of Cerebral Blood Flow & Metabolism  2016, Vol. 36(4) 702–708

Mechanisms of Comorbidities Associated with the Metabolic Syndrome: insights from the JCR:LA-cp Corpulent Rat Strain

Abdoulaye Diane, W. David Pierce, Sandra E. Kelly, Sharon Sokolik, Faye Borthwick, Miriam Jacome-Sosa, Rabban Mangat, Jesus Miguel Pradillo, Stuart McRae Allan, Megan R. Ruth, Catherine J. Field, Rebecca Hutcheson, Petra Rocic, James C. Russell, Donna F. Vine y Spencer D. Proctor.

Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke

Macarena Hernández-Jiménez, Diego Martínez-López, Enrique Gabande-Rodríguez, Adrián Martin-Segura, Ignacio Lizasoain, Maria D. Ledesma, Carlos G. Dotti y Maria A. Moro.

The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia

María Isabel Cuartero, Juan de la Parra, Alicia García-Culebras, Iván Ballesteros, Ignacio Lizasoain y María Ángeles Moro.

Chemoproteomic Approach to Explore the Target Profile of GPCR ligands: Application to 5-HT1A and 5-HT6 Receptors

Ana M. Gamo, Juan A. González-Vera, Ainoa Rueda-Zubiaurre, Dulce Alonso, Henar Vázquez-Villa, Lidia Martín-Couce, Óscar Palomares, Juan A. López, Mar Martín-Fontecha, Bellinda Benhamffl, María L. López-Rodríguez y Silvia Ortega-Gutiérrez.

Potent anticholinesterasic and neuroprotective pyranotacrines as inhibitors of beta-amyloid aggregation, oxidative stress and tauphosphorylation for Alzheimer's disease

Nuria García-Font, Hasna Hayour, Ali Belfaitah, Jorge Pedraz, Ignacio Moraleda, Isabel Iriepa, Abdelmalek Bouraiou, Mourad Chioua, José Marco-Contelles y María Jesús Oset-Gasque.

European Journal of Medicinal Chemistry 118 (2016) 178-192

Dissecting the Role of Epidermal Growth Factor Receptor Catalytic Activity During Liver Regeneration and Hepatocarcinogenesis

Judit López-Luque, Daniel Caballero-Díaz, Adoración Martinez-Palacian, César Roncero, Joaquim Moreno-Cáceres, María García-Bravo, Esther Grueso, Almudena Fernández, Eva Crosas-Molist, María García-Álvaro, Annalisa Addante, Esther Bertran, Angela M. Valverde, Águeda González-Rodríguez, Blanca Herrera, Lluis Montoliu, Teresa Serrano Jose-Carlos Segovia, Margarita Fernández, Emilio Ramos, Aranzazu Sánchez e Isabel Fabregat.

Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer’s disease

Giuseppina Tommonaro, Nuria García-Font, Rosa Maria Vitale, Boris Pejin, Carmine Iodice, Sixta Cañadas, José Marco-Contelles, María Jesús Oset-Gasque.

European Journal of Medicinal Chemistry 122 (2016) 326-338

Tetrahydroisoquinoline-Derived Urea and 2,5-Diketopiperazine Derivatives as Selective Antagonists of the Transient Receptor Potential Melastatin 8 (TRPM8) Channel Receptor and Antiprostate Cancer Agents

Luciano De Petrocellis, Francisco J. Arroyo, Pierangelo Orlando, Aniello Schiano Moriello, Rosa María Vitale, Pietro Amodeo, Aránzazu Sánchez, Cesáreo Roncero, Giulia Bianchini, Antonia Martín, Pilar López-Alvarado y J. Carlos Menéndez.

Melatonin and Nitrones As Potential Therapeutic Agents for Stroke

Alejandro Romero, Eva Ramos, Paloma Patiño, Maria J. Oset-Gasque, Francisco López-Muñoz, José Marco-Contelles, María I. Ayuso y Alberto Alcázar.

Multi-TargetDirectedDonepezil-LikeLigandsforAlzheimer’s Disease

Mercedes Unzeta, GerardEsteban, IreneBolea, WieslawaA.Fogel, Rona R.Ramsay, MoussaB.H.Youdim, KeithF.Tipton y José Marco-Contelles.

St Andrews Research Repository 2016

N‑Benzylpiperidine Derivatives as α7 Nicotinic Receptor Antagonists

Manuel Criado, José Mulet, Francisco Sala, Salvador Sala, Inés Colmena, Luis Gandía, Oscar M. Bautista-Aguilera, Abdelouahid Samadi, Mourad Chioua y José Marco-Contelles.

ASS234,AsaNewMulti-TargetDirectedPropargylamineforAlzheimer’sDiseaseTherapy

José Marco-Contelles, Mercedes Unzeta, Irene Bolea, Gerard Esteban, Rona R. Ramsay, Alejandro Romero, Ricard Martínez-Murillo, M. Carmo Carreiras y Lhassane Ismaili.

Upregulation of Antioxidant Enzymes by ASS234, a Multitarget Directed Propargylamine for Alzheimer’s Disease Therapy

Eva Ramos, Alejandro Romero, José Marco-Contelles y Javier del Pino.

Bacterial translocation affects intracellular neuroinflammatory pathways in a depression-like model in rats

David Martín-Hernández, Javier R. Caso, Álvaro G. Bris, Sandra R. Maus, José L.M. Madrigal, Borja García-Bueno, Karina S. MacDowell, Luis Alou, Maria Luisa Gómez-Lus y Juan C. Leza.

Neuropharmacology 103 (2016) 122-133

Modulation of the antioxidant nuclear factor (erythroid 2-derived)-like 2 pathway by antidepressants in rats

David Martín-Hernández, Álvaro G. Bris, Karina S. MacDowell, Borja García-Bueno, José L.M. Madrigal, Juan C. Leza y Javier R. Caso.

Neuropharmacology 103 (2016) 1-13

BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year

M. Martinez-Cengotitabengoa, K.S. MacDowell, S. Alberich, F.J. Diaz, B. Garcia-Bueno, R. Rodríguez-Jiménez, M. Bioque, E. Berrocoso, M. Parellada, A. Lobo, P.A. Saiz, C. Matute, M. Bernardo, A. Gonzalez-Pinto, J.C. Leza y FLAMM-PEPs.

Schizophrenia Bulletin 2016 Jan;42(1):142-51

Nucleotides in neuroregeneration and neuroprotection

M.Teresa Miras-Portugal, Rosa Gomez-Villafuertes, Javier Gualix, Juan Ignacio Diaz-Hernández, Antonio R. Artalejo, Felipe Ortega, Esmerilda G. Delicado y Raquel Perez-Sen.

Neuropharmacology 104 (2016) 243-254

The use of cannabinoids as anticancer agents

Guillermo Velasco, Sonia Hernández-Tiedra, David Dávila  Mar Lorente ^.

Prog Neuropsychopharmacol Biol Psychiatry 2016 Jan 4;64:259-66