Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain.

Arribas-Blázquez M, Olivos-Oré LA, Barahona MV, Sánchez de la Muela M, Solar V, Jiménez E, Gualix J, McIntosh JM, Ferrer-Montiel A, Miras-Portugal MT, Artalejo AR.

Int J Mol Sci. 2019 Jan 3;20(1). pii: E155. doi: 10.3390/ijms20010155

Identification of IQM-266, a Novel DREAM Ligand That Modulates KV4 Currents

Peraza DA, Cercós P, Miaja P, Merinero YG, Lagartera L, Socuéllamos PG, Izquierdo García C, Sánchez SA, López-Hurtado A, Martín-Martínez M, Olivos-Oré LA, Naranjo JR, Artalejo AR, Gutiérrez-Rodríguez M, Valenzuela C

Front Mol Neurosci. 2019 Feb 4;12:11. doi: 10.3389/fnmol.2019.00011. eCollection 2019

Changes in brain kynurenine levels via gut microbiota and gut-barrier disruption induced by chronic ethanol exposure in mice

Giménez-Gómez P, Pérez-Hernández M, O'Shea E, Caso JR, Martín-Hernandez D, Cervera LA, Centelles MLG, Gutiérrez-Lopez MD, Colado MI

FASEB J, 33 (11), 12900-12914, 2019

Structure–Effect Relationships of Novel Semi-Synthetic Cannabinoid Derivatives

Marcus R. Götz , Juan A. Collado, Javier Fernández Ruiz, Bernd L. Fiebich, Laura García Toscano, María Gómez Cañas, Oskar Koch, Andreas Leha, Eduardo Muñoz, Carmen Navarrete, Maria R. Pazos y Ulrike Holzgrabe.

Frontiers in Pharmacology    doi: 10.3389/fphar.2019.01284 november 2019

Development of An Oral Treatment with the PPAR--Acting Cannabinoid VCE-003.2 Against the Inflammation-Driven Neuronal Deterioration in Experimental Parkinson’s Disease

Sonia Burgaz, Concepción García, Maria Gómez-Cañas, Eduardo Muñoz y Javier Fernández-Ruiz.

Molecules MPDI 2019  Jul 25;24(15):2702

Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients

Pedro Araos, Rebeca Vidal, Esther O’Shea, María Pedraz, Nuria García-Marchena, Antonia Serrano, Juan Suárez, Estela Castilla-Ortega, Juan Jesús Ruiz,

Rafael Campos-Cloute, Luis J. Santín, Fernando Rodríguez de Fonseca, Francisco Javier Pavón y María Isabel Colado.

Scientific Reports 9(1):16842 2019

Targeting glial cannabinoid CB2 receptors to delay the progression of the pathological phenotype in TDP-43 (A315T) transgenic mice, a model of amyotrophic lateral sclerosis

Francisco Espejo Porras, Laura García Toscano, Carmen Rodríguez Cueto, Irene Santos García, Eva de Lago y Javier Fernández Ruiz.

British Journal of Pharmacology   176 1585–1600 1585  2019

The biomedical challenge of neurodegenerative disorders: an opportunity for cannabinoid-based therapies to improve on the poor current therapeutic outcomes

Javier Fernández Ruiz

British Journal of Pharmacology  176 1370–1383 1370  2019

Cannabidiol Administration Prevents Hypoxia-Ischemia-Induced Hypomyelination in Newborn Rats

María Ceprián, Carlos Vargas, Laura García-Toscano, Federica Penna, Laura Jiménez-Sánchez, Svein Achicallende, Izaskun Elezgarai, Pedro Grandes, William Hind , M. Ruth Pazos y José Martínez-Orgado.

Frontiers in Pharmacology doi: 10.3389/fphar.2019.01131 september 2019

Endocannabinoid System in Spixia Type-3 and Other Autosomal-Dominant Cerebellar Ataxias: Potential Role in Pathogenesis and Expected Relevance as Neuroprotective Targetsnocerebellar Ata

María Gómez-Ruiz, Carmen Rodríguez-Cueto, Eva Luna-Piñel, Mariluz Hernández-Gálvez y Javier Fernández Ruiz.

Frontiers in Pharmacology   Published: 24 April 2019 doi: 10.3389/fnmol.2019.00094

Morphine self-administration alters the expression of translational machinery genes in the amygdala of male Lewis rats

Marcos Ucha , Santiago M Coria, Adrián E Núñez, Raquel Santos Toscano, David Roura Martínez, Javier Fernández Ruiz, Alejandro Higuera Matas y Emilio Ambrosio.

Journal of Psychopharmacology  2019 Jul;33(7):882-893

Association Between Medication Adherence and Oxidative Stress in Patients With First-Episode Mania

Saínza García, Susana Alberich, Karina S. MacDowell, Mónica Martínez-Cengotitabengoa, Purificación López, Iñaki Zorrilla, Juan Carlos Leza y Ana González Pinto.

BRIEF RESEARCH REPORT published: 26 March 2019 doi: 10.3389/fpsyt.2019.00162

Association of chronic inflammation and perceived stress with abnormal functional connectivity in brain areas involved with interoception in hepatitis C patients

Giovanni Oriolo, Laura Blanco-Hinojo, Ricard Navines, Zoe Mariño, David Martín-Hernández, Myriam Cavero, Dolores Gimenez, Javier Caso, Lucile Capuron,Xavier Forns, Jesús Pujol, Ricard Sola y Rocío Martín-Santosa.

Brain, Behavior, and Immunity 80 204-218  2019

CIBERSAM: Ten years of collaborative translational research in mental disorders

Estela Salagre, Celso Arango, Francesc Artigas, José Luis Ayuso Mateos, Miquel Bernardo, Josefina Castro Fornieles, Julio Bobes, Manuel Desco, Lourdes Fañanás, Ana González Pinto, Josep María Haro, Juan Carlos Leza, Peter J. Mckenna, José Javier Meana, José Manuel Menchón, Juan Antonio Micó, Tomás Palomo, Ángel Pazos, Víctor Pérez, Jerónimo Saiz Ruiz, Julio Sanjuán, Rafael Tabarés Seisdedos, Benedicto Crespo-Facorro, Miquel Casas, Elisabet Vilella, Diego Palao, Jose Manuel Olivares, Roberto Rodríguez Jiménez, Eduard Vieta.

Rev Psiquiatr Salud Ment (Barc.) 12(1):1-8  2019

A Neutrophil Timer Coordinates Immune Defense and Vascular Protection

José M. Adrover, Carlos del Fresno, Georgiana Crainiciuc, María A. Moro, Borja Ibañez y Andrés Hidalgo.

Inmunity  2019 Feb 19;50(2):390-402. 10

Risperidone Ameliorates Prefrontal Cortex Neural Atrophy and Oxidative/Nitrosative Stress in Brain and Peripheral Blood of Rats with Neonatal Ventral Hippocampus Lesion.

Tendilla-Beltrán H, Meneses-Prado S, Vázquez-Roque RA, Tapia-Rodríguez M, Vázquez-Hernández AJ, Coatl-Cuaya H, Martín-Hernández D, MacDowell KS, Garcés-Ramírez L, Leza JC, Flores G.

J Neurosci.  2019 Oct 23;39(43):8584-8599

Differences in the regulation of inflammatory pathways in adolescent- and adult-onset first-episode psychosis

Moreno C, Parellada M, MacDowell KS, García-Bueno B, Cabrera B, González-Pinto A, Saiz P, Lobo A, Rodriguez-Jimenez R, Berrocoso E, Bernardo M, Leza JC

Eur Child Adolesc Psychiatry.  2019 Oct;28(10):1395-1405

Association of chronic inflammation and perceived stress with abnormal functional connectivity in brain areas involved with interoception in hepatitis C patients

Oriolo G, Blanco-Hinojo L, Navines R, Mariño Z, Martín-Hernández D, Cavero M, Gimenez D, Caso J, Capuron L, Forns X, Pujol J, Sola R, Martin-Santos R

Brain Behav Immun.  2019 Aug;80:204-218

Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats.

Martín-Hernández D, Tendilla-Beltrán H, Madrigal JLM, García-Bueno B, Leza JC, Caso JR.

Mol Neurobiol.  2019 Jan 56(1) 490-501

Modulation of Monoaminergic Systems by Antidepressants in the Frontal Cortex of Rats After Chronic Mild Stress Exposure

Martín-Hernández D, Pereira MP, Tendilla-Beltrán H, Madrigal JLM, García-Bueno B, Leza JC, Caso JR

Mol Neurobiol.  2019 Nov;56(11):7522-7533.

Risperidone administered during adolescence induced metabolic, anatomical and inflammatory/oxidative changes in adult brain: A PET and MRI study in the maternal immune stimulation animal model

Casquero-Veiga M, García-García D, MacDowell KS, Pérez-Caballero L, Torres-Sánchez S, Fraguas D, Berrocoso E, Leza JC, Arango C, Desco M, Soto-Montenegro ML.

Eur Neuropsychopharmacol. 2019 Jul;29(7):880-896.

Reboxetine Treatment Reduces Neuroinflammation and Neurodegeneration in the 5xFAD Mouse Model of Alzheimer's Disease: Role of CCL2.

Gutiérrez IL, González-Prieto M, Caso JR, García-Bueno B, Leza JC, Madrigal JLM.

Mol Neurobiol. 2019 Jul 11. doi: 10.1007/s12035-019-01695-6

Oxidative Stress and Inflammation in First-Episode Psychosis: A Systematic Review and Meta-analysis

David Fraguas, Covadonga M. Díaz-Caneja, Miriam Ayora, Fabián Hernández Álvarez, Alberto Rodríguez Quiroga, Sandra Recio, Juan C. Leza y Celso Arango.

Schizophrenia Bulletin 18;45(4):742-751  2019

Changes in brain kynurenine levels via gut microbiota and gut-barrier disruption induced by chronic ethanol exposure in mice.

Giménez-Gómez P, Pérez-Hernández M, O'Shea E, Caso JR, Martín-Hernandez D, Cervera LA, Centelles MLG, Gutiérrez-Lopez MD, Colado MI

FASEB J. 2019 Nov;33(11):12900-12914.

Early versus late stage schizophrenia. What markers make the difference?

García-Álvarez L, García-Portilla MP, Caso JR, de la Fuente-Tomás L, González-Blanco L, Sáiz Martínez P, Leza JC, Bobes J.

World J Biol Psychiatry. 2019 Feb;20(2):159-165

Effects of electroconvulsive therapy in the systemic inflammatory balance of patients with severe mental disorder

Miquel Bioque, Karina S. Mac-Dowell, Ana Meseguer, Elisabet Macau, Ricard Valero,  Eduard Vieta, Juan C. Leza  y Miquel Bernardo.

PCN Psychiatry and Clinical Neurosciences 2019 Oct;73(10):628-635

Oleoylethanolamide, Neuroinflammation, and Alcohol Abuse

Laura Orio, Francisco Alen, Francisco Javier Pavón, Antonia Serrano y Borja García Bueno.

Frontiers in Molecular Neuroscience  2019 Jan 9;11:490  doi: 10.3389/fnmol.2018.00490

Astroglial monoacylglycerol lipase controls mutant huntingtin-induced damage of striatal neurons.

Ruiz-Calvo A, Bajo-Grañeras R, Maroto IB, Zian D, Grabner GF, García-Taboada E, Resel E, Zechner R, Zimmermann R, Ortega-Gutiérrez S, Galve-Roperh I, Bellocchio L, Guzmán M.

Neuropharmacology  2019 May 15;150:134-144

Contribution of Altered Endocannabinoid System to Overactive mTORC1 Signaling in Focal Cortical Dysplasia

García-Rincón D, Díaz-Alonso J, Paraíso-Luna J, Ortega Z, Aguareles J, de Salas-Quiroga A, Jou C, de Prada I, Martínez-Cerdeño V, Aronica E, Guzmán M, Pérez-Jiménez MÁ, Galve-Roperh I.

Front Pharmacol   2019 Jan 9;9:1508

Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration

José Aguareles, Juan Paraíso-Luna, Belén Palomares, Raquel Bajo-Grañeras, Carmen Navarrete, Andrea Ruiz-Calvo, Daniel García-Rincón, Elena García-Taboada, Manuel Guzmán, Eduardo Muñoz and Ismael Galve-Roperh

Translational Neurodegeneration  2019 Mar 8;8:9  doi: 10.1186/s40035-019-0148

Physiopathological Role of the Vesicular Nucleotide Transporter (VNUT) in the Central Nervous System: Relevance of the Vesicular Nucleotide Release as a Potential Therapeutic Target

Miras-Portugal MT, Menéndez-Méndez A, Gómez-Villafuertes R, Ortega F, Delicado EG, Pérez-Sen R, Gualix J. 

Front Cell Neurosci 13: 224, 2019

Dual-specificity phosphatase regulation in neurons and glial cells

Pérez-Sen R, Queipo MJ, Gil-Redondo JC, Ortega F, Gómez-Villafuertes R, MirasPortugal MT, Delicado EG

Int J Mol Sci. 20(8): E1999, 2019

Abolition of aberrant neurogenesis ameliorates cognitive impairment after stroke in mice

María Isabel Cuartero, Juan de la Parra, Alberto Pérez Ruiz, Isabel Bravo Ferrer, Violeta Durán Laforet, Alicia García-Culebras, Juan Manuel García Segura, Jagroop Dhaliwal, Paul W. Frankland, Ignacio Lizasoain y María Ángeles Moro.

The Journal of Clinical Investigation  2019 Apr 1;129(4):1536-1550

Delayed Effects of Acute Reperfusion on Vascular Remodeling and Late-Phase Functional Recovery After Stroke

Violeta Durán Laforet, David Fernández López, Alicia García Culebras, Juan González Hijón, Ana Moraga, Sara Palma Tortosa, Isaac García Yébenes, Adrián Vega Pérez, Ignacio Lizasoain y María Ángeles Moro.

ORIGINAL RESEARCH published: 23 July 2019 doi: 10.3389/fnins.2019.00767

Effects of aging and comorbidities on endothelial progenitor cells

Jesús M. Pradillo, Alba Grayston, Violeta Medina-Alonso, Mercedes Arrúe, Ignacio Lizasoain, Anna Rosell.

Conditioning Medicine, 2019. 2(1):18-29

Lack of the aryl hydrocarbon receptor accelerates aging in mice

Isabel Bravo Ferrer, María I. Cuartero, Violeta Medina, Dalia Ahedo Quero, Carolina Peña Martínez, Alberto Pérez Ruiz, M. Encarnación Fernández-Valle, Catalina Hernández-Sánchez, Pedro M. Fernández-Salguero, Ignacio Lizasoain y María A. Moro.

The faseb JOURNAL  RESEARCH 2019. 2(1):18-29

Pharmacological Modulation of Neutrophil Extracellular Traps Reverses Thrombotic Stroke tPA (Tissue-Type Plasminogen Activator) Resistance

Carolina Peña Martínez, Violeta Durán Laforet, Alicia García Culebras, Fernando Ostos, Macarena Hernández Jiménez, Isabel Bravo Ferrer, Alberto Pérez Ruiz, Federico Ballenilla, Jaime Díaz Guzmán, Jesús M. Pradillo, Ignacio Lizasoain y María A. Moro.

Stroke. 2019 Nov;50(11):3228-3237

Role of TLR4 (Toll-Like Receptor 4) in N1/N2 Neutrophil Programming After Stroke

Alicia García Culebras, Violeta Durán Laforet, Carolina Peña Martínez, Ana Moraga, Ivan Ballesteros, Maria I. Cuartero, Juan de la Parra, Sara Palma Tortosa, Andrés Hidalgo, Angel L. Corbí, María A. Moro e Ignacio Lizasoain.

Stroke 2019 Oct;50(10):2922-2932

Toll-like receptor 4 regulates subventricular zone proliferation and neuroblast migration after experimental stroke

Sara Palma Tortosa, Olivia Hurtado, Jesús Miguel Pradillo, Raquel Ferreras Martín, Isaac García-Yébenes, Alicia García Culebras, Ana Moraga, María Ángeles Moro e Ignacio Lizasoain.

Brain, Behavior, and Immunity 80 2019 573-582

Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration

José Aguareles, Juan Paraíso-Luna, Belén Palomares, Raquel Bajo-Grañeras, Carmen Navarrete, Andrea Ruiz-Calvo, Daniel García-Rincón, Elena García Taboada, Manuel Guzmán, Eduardo Muñoz e Ismael Galve-Roperh.

Aguareles et al. Translational Neurodegeneration (2019) 8:9

Therapeutic targeting of HER2–CB2R heteromers in HER2-positive breast cancer

Sandra Blasco-Benito, Estefanía Moreno, Marta Seijo-Vila, Isabel Tundidor, Clara Andradasa, María M. Caffarel, Miriam Caro-Villalobos, Leyre Urigüen, Rebeca Diez-Alarcia, Gema Moreno Bueno, Lucía Hernández, Luis Manso, Patricia Homar-Ruano, Peter J. McCormick, Lucka Bibic, Cristina Bernadó-Morales, Joaquín Arribas, Meritxell Canals, Vicent Casadó, Enric I. Canela, Manuel Guzmán, Eduardo Pérez Gómez y Cristina Sánchez.

Priority Considerations for Medicinal Cannabis-Related Research

Marcel O. Bonn-Miller, Charles V. Pollack, Jr., David Casarett, Richard Dart, Mahmoud ElSohly, Larry Good, Manuel Guzmán, Lumír Hanus, Kevin P. Hill, Marilyn A. Huestis, Eric Marsh, Susan Sisley, Nancy Skinner, Judith Spahr, Ryan Vandrey, Eugene Viscusi, Mark A. Ware y Donald Abrams.

Cannabis and Cannabinoid Research Volume 4, Number 3, 2019

Contribution of Altered Endocannabinoid System to Overactive mTORC1 Signaling in Focal Cortical Dysplasia

Daniel García-Rincón, Javier Díaz-Alonso, Juan Paraíso-Luna, Zaira Ortega, José Aguareles, Adán de Salas-Quiroga, Cristina Jou, Inmaculada de Prada, Verónica Martínez-Cerdeño, Eleonora Aronica, Manuel Guzmán, María Ángeles Pérez-Jiménez e Ismael Galve-Roperh.

Frontiers in pharmacology published: 09 January 2019 doi: 10.3389/fphar.2018.01508

Overexpression of P2X3 and P2X7 receptors and TRPV1 channels in adrenomedullary chromaffin cells in a rat model of neuropathic pain

Arribas-Blazquez M, Olivos-Ore, LA, Barahona MV, Sanchez de la Muela M, Solar V, Jimenez E, Gualix J, McIntosh JM, Ferrer-Montiel A, Miras-Portugal MT, Artalejo AR

Int J Mol Sci. 20(1): E155, 2019

Inhibiting SUMO1-mediated SUMOylation induces autophagymediated cancer cell death and reduces tumour cell invasión via RAC1

Mar Lorente, Ana Garcı́a-Casas, Nélida Salvador, Angélica Martı́nez López, Estibaliz Gabicagogeascoa, Guillermo Velasco, Lucı́a López-Palomar y Sonia Castillo-Lluva.

Journal of Cell Science (2019) 132, jcs234120

S194-P-FADD as a marker of aggressiveness and por prognosis in human T-cell lymphoblastic lymphoma

José L. Marín Rubio, Eduardo Pérez Gómez, Jose Fernández Piqueras y Maria Villa Morales.

Carcinogenesis, 2019, 1–9   Advance Access publication February 26, 2019

The loss of β-adrenergic receptor mediated release potentiation in a mouse model of fragile X syndrome.

García-Font N, Martín R, Torres M, Oset-Gasque MJ, Sánchez-Prieto J.

Neurobiology of Disease, 2019 Oct;130:104482. doi: 10.1016/j.nbd.2019.104482.

Espejo-Porras F, García-Toscano L, Rodríguez-Cueto C, Santos-García I, de Lago E, Fernández-Ruiz J

British Journal of Pharmacology,  2019 May;176(10):1585-1600

The biomedical challenge of neurodegenerative disorders: an opportunity for cannabinoid-based therapies to improve on the poor current therapeutic outcomes.

Fernández-Ruiz, J

British Journal of Pharmacology,  2019 May;176(10):1370-1383

Structure-effect relationships of novel semi-synthetic cannabinoid derivates

Götz MR, Collado JA, Fernández-Ruiz J, Fiebich BL, García-Toscano L, Gómez-Cañas M, Koch O, Leha A, Muñoz E, Navarrete C, Pazos MR, Holgrabe U

Rbfox1 up-regulation impairs BDNFdependent hippocampal LTP by dysregulating TrkB isoform expression levels

Francesco Tomassoni-Ardori, Gianluca Fulgenzi, Jodi Becker, Colleen Barrick, Mary Ellen Palko, Skyler Kuhn, Vishal Koparde, Maggie Cam, Sudhirkumar Yanpallewar, Shalini Oberdoerffer y Lino Tessarollo.

Elifes sciences.org 2019  Aug 20;8:e49673

P2 receptor interaction and signalling cascades in neuroprotection

Mª Teresa Miras Portugal, Mª José Queipo, Juan Carlos Gil Redondo, Felipe Ortega,

Rosa Gómez Villafuertes, Javier Gualix, Esmerilda G. Delicado y Raquel Pérez-Sen.

Brain research bulletin 2019 Sep;151:74-83

Photoconversion of FM1-43 Reveals Differences in Synaptic Vesicle Recycling and Sensitivity to Pharmacological Disruption of Actin Dynamics in Individual Synapses

Alberto Rampérez, David Bartolomé-Martín, Angeles García-Pascual, José Sánchez-Prieto y Magdalena Torres.

ACS Chem Neurosci  2019 Apr 17;10(4):2045-2059

A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia

Nagore I. Marín-Ramos, Moisés Balabasquer, Francisco J. Ortega-Nogales, Iván R. Torrecillas, Ana Gil-Ordóñez, Beatriz Marcos-Ramiro, Pedro Aguilar-Garrido, Ian Cushman, Antonio Romero, Francisco J. Medrano, Consuelo Gajate, Faustino Mollinedo, Mark R. Philips, Mercedes Campillo, Miguel Gallardo, Mar Martín-Fontecha, María L. López-Rodríguez y Silvia Ortega-Gutiérrez.

J Med Chem   2019 Jul 11;62(13):6035-6046

Blocking Ras inhibition as an antitumor strategy

Nagore I. Marín-Ramos, Silvia Ortega-Gutiérrez y María L. López-Rodríguez.

Semin Cancer Biol  2019 Feb;54:91-100

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

Andrea Canal-Martín, Javier Sastre, María José Sánchez-Barrena, Angeles Canales, Sara Baldominos, Naiara Pascual, Loreto Martínez-González, Dolores Molero, Mª Encarnación Fernández-Valle, Elena Sáez, Patricia Blanco-Gabella, Elena Gómez-Rubio, Sonsoles Martín-Santamaría, Almudena Sáiz, Alicia Mansilla, F Javier Cañada, Jesús Jiménez-Barbero, Ana Martínez y  Ruth Pérez-Fernández.

Nat Commun   2019 Jun 26;10(1):2798