Regulation of the voltage-dependent sodium channel NaV1.1 by AKT1

Marina Arribas-Blázquez, Dolores Piniella, Luis A. Olivos-Oré, David Bartolomé-Martín, Cristiana Leite, Cecilio Giménez, Antonio R. Artalejo, Francisco Zafra.

Neuropharmacology 197 (2021) 108745

Salient brain entities labelled in P2rx7‑EGFP reporter mouse embryos include the septum, roof plate glial specializations and circumventricular ependymal organs

Felipe Ortega, Rosa Gomez‑Villafuertes, María Benito‑León, Margaret Martínez de la Torre,  Luis A. Olivos‑Oré, Marina Arribas‑Blazquez,María Victoría Gomez‑Gaviro, Arturo Azcorra, Manuel Desco, Antonio R. Artalejo, Luis Puelles, María Teresa Miras‑Portugal.

Combining low-density cell culture, single-cell tracking, and patch-clamp to monitor the behavior of postnatal murine cerebellar neural stem cells

Increased kynurenine concentration attenuates serotonergic neurotoxicity induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats through activation of aryl hydrocarbon receptor⋆

C. Abuin-Martínez, R. Vidal, M.D. Gutiérrez-López, M. Pérez-Hernández, P. Giménez-Gómez, N. Morales-Puerto, E. O’Shea,M.I. Colado.

5‑HT4 Receptors Are Not Involved in the Effects of Fluoxetine in the Corticosterone Model of Depression

Josep Amigo, Emilio Garro-Martinez, Rebeca Vidal Casado, Valerie Compan, Fuencisla Pilar-Cuéllar,
Angel Pazos, Alvaro Díaz,* and Elena Castro

Acs Chemical Neuroscience

Decreased kynurenine pathway potentiate resilience to social defeat effect on cocaine reward

Addiction and the kynurenine pathway: A new dancing couple?

Nuria Morales-Puerto, Pablo Giménez-Gómez, Mercedes Pérez-Hernández,Cristina Abuin-Martínez, Leticia Gil de Biedma-Elduayen, Rebeca Vidal,
María Dolores Gutiérrez-López, Esther O'Shea, María Isabel Colado.

Nucleotides-Induced Changes in the Mechanical Properties of Living Endothelial Cells and Astrocytes, Analyzed by Atomic Force Microscopy

Juan Carlos Gil-Redondo, Jagoba Iturri, Felipe Ortega, Raquel Pérez-Sen, AndreasWeber, María Teresa Miras-Portugal, José Luis Toca-Herrera y Esmerilda G. Delicado.

P2X7 receptors in the central nervous system

María Teresa Miras-Portugal, Felipe Ortega, Rosa Gómez-Villafuertes, Javier Gualix, Raquel Pérez-Sen, Esmerilda G. Delicado.

Dissecting the Purinergic Signaling Puzzle

Raquel Pérez-Sen y Esmerilda G. Delicado.

Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration

M. Galán‑Ganga, C. Rodríguez‑Cueto, J. Merchán‑Rubira, F. Hernández, J. Ávila, M. Posada‑Ayala, J. L. Lanciego, E. Luengo, M. G. Lopez, A. Rábano, J. Fernández‑Ruiz y I. Lastres‑Becker.

Targeting the CB₂ receptor and other endocannabinoid elements to delay disease progression in amyotrophic lateral sclerosis

Inactivation of the CB₂ receptor accelerated the neuropathological deterioration in TDP-43 transgenic mice, a model of amyotrophic lateral sclerosis

Phytocannabinoids Versus Endocannabinoids. A Modern View of the Endocannabinoid System

Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis

Analogues of cannabinoids as multitarget drugs in the treatment of Alzheimer’s disease

José María Sánchez Montero, Angel Agis-Torres, David Solano, Monica Sollhuber, María Fernandez, Wilma Villaro, María Gómez-Cañas, Moisés García-Arencibia, Javier Fernández-Ruiz, Javier Egea, María Isabel Martín, Rocío Girón.

Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments

Valentina Satta, Cristina Alonso, Paula Díez, Soraya Martín-Suárez, Marta Rubio, Juan M. Encinas, Javier Fernández-Ruiz y Onintza Sagredo.

Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3 as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis

Loreto Martínez-González, Claudia Gonzalo-Consuegra, Marta Gómez-Almería, Gracia Porras, Eva de Lago, Ángeles Martín-Requero y Ana Martínez.

Retinal Ganglion Cell Loss and Microglial Activation in a SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

Pilar Rojas, Ana I. Ramírez, Manuel Cadena, José A. Fernández-Albarral, Elena Salobrar-García, Inés López-Cuenca, Irene Santos-García, Eva de Lago, José L. Urcelay-Segura, José M. Ramírez, Rosa de Hoz y Juan J. Salazar.

Neuroprotection with the cannabigerol quinone derivative VCE-003.2 and its analogs CBGA-Q and CBGA-Q-Salt in Parkinson’s disease using 6-hydroxydopamine-lesioned mice

Sonia Burgaz, Concepción García, María Gómez-Cañas, Carmen Navarrete, Adela García-Martín, Alain Rolland, Carmen del Río, María J. Casarejos, Eva Muñoz, Claudia Gonzalo-Consuegra, Eduardo Muñoz, Javier Fernández-Ruiz.

Neuroprotection with the cannabidiol quinone derivative 2 VCE-004.8 (EHP-101) against 6-hydroxydopamine in cell and 3 murine models of Parkinson’s disease 4

Sonia Burgaz, Concepción García, María Gómez-Cañas, Alain Rolland, Eduardo Muñoz y Javier Fernández Ruiz.

Molecules. 2021 May 28;26(11):3245. doi: 10.3390/molecules26113245

Preclinical Investigation in Neuroprotective Effects of the GPR55 Ligand VCE-006.1 in Experimental Models of Parkinson’s Disease and Amyotrophic Lateral Sclerosis

Sonia Burgaz, Concepción García, Claudia Gonzalo-Consuegra, Marta Gómez-Almería, Francisco Ruiz-Pino, Juan Diego Unciti, María Gómez-Cañas, Juan Alcalde, Paula Morales, Nadine Jagerovic, Carmen Rodríguez-Cueto, Eva de Lago, Eduardo Muñoz y Javier Fernández-Ruiz.

Preclinical investigation of β-caryophyllene as a therapeutic agent in an experimental murine model of Dravet syndrome

Cristina Alonso, Valentina Satta, Paula Díez-Gutiérrez, Javier Fernández-Ruiz,Onintza Sagredo.

(+)-trans-Cannabidiol-2-hydroxy pentyl is a dual CB1R antagonist/CB2R agonist that prevents diabetic nephropathy in mice

Identification of BiP as a CB1 Receptor-Interacting Protein That Fine-Tunes Cannabinoid Signaling in the Mouse Brain

Carlos Costas-Insua, Estefanía Moreno, Irene B. Maroto, Andrea Ruiz-Calvo, Raquel Bajo-Grañeras, David Martín-Gutiérrez, Rebeca Diez-Alarcia, M. Teresa Vilaró, Roser Cortés, Nuria García-Font, Ricardo Martín, Marc Espina, Joaquín Botta, Silvia Ginés, Peter J. McCormick, José Sánchez-Prieto, Ismael Galve-Roperh, Guadalupe Mengod, Leyre Urigüen, Giovanni Marsicano, Luigi Bellocchio, Enric I. Canela, Vicent Casadó, Ignacio Rodríguez-Crespo y Manuel Guzmán.

Effective glutamate clearance from the systemic circulation by hemodialysis: Potential relevance for cerebral ischemia management

Patricia Martínez-Miguel, Marta Albalate, Violeta Durán-Laforet, Carolina Peña-Martínez, Patricia de Sequera, Hanane Bouarich, Korina Peña-Esparragoza, Susana López-Ongil. Ignacio Lizasoain, José Sánchez-Prieto, Magdalena Torres, María Ángeles Moro, Diego Rodríguez-Puyol.

Cancer Treatment: Preclinical & Clinical

Donald I. Abrams, Guillermo Velasco, Chris Twelve, Ramesh K. Ganju, Gil Bar-Sela.

J Natl Cancer Inst Monogr (2021) 2021(58): lgab010

Δ⁹ -Tetrahydrocannabinol promotes functional remyelination in the mouse brain

Identification of BiP as a CB₁ Receptor-Interacting Protein That Fine-Tunes Cannabinoid Signaling in the Mouse Brain

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity

Cannabinoid Cancer Biology and Prevention

The Pseudokinase TRIB3 Negatively Regulates the HER2 Receptor Pathway and Is a Biomarker of Good Prognosis in Luminal Breast Cancer

Brain and Lung Imaging Correlation in Patients with COVID-19: Could the Severity of Lung Disease Reflect the Prevalence of Acute Abnormalities on Neuroimaging? A Global Multicenter Observational Study

Fewer COVID-19-associated strokes and reduced severity during the second COVID-19 wave: The Madrid Stroke Network

Influence of metabolic syndrome on post-stroke outcome, angiogenesis and vascular function in old rats determined by dynamic contrast enhanced MRI

New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases

Pathophysiological and pharmacological relevance of TLR4 in peripheral immune cells after stroke

V. Durán-Laforet, C. Peña-Martínez, A. García-Culebras, L. Alzamora, M.A. Moro, I. Lizasoain.

Pharmacol Ther 2021 Dec;228:107933. doi: 10.1016/j.pharmthera.2021.107933. Epub 2021 Jun 24

Post-stroke Neurogenesis: Friend or Foe?

María Isabel Cuartero, Alicia García-Culebras, Cristina Torres-López, Violeta Medina, Enrique Fraga, Sandra Vázquez-Reyes, Tania Jareño-Flores, Juan M. García-Segura, Ignacio Lizasoain y María Ángeles Moro.

Presence of Extra-Criteria Antiphospholipid Antibodies Is an Independent Risk Factor for Ischemic Stroke

Retinal Thickness Changes Over Time in a Murine AD Model APP ^NL-F/NL-F

Role of TLR4 in Neutrophil Dynamics and Functions: Contribution to Stroke Pathophysiology

Stroke Acute Management and Outcomes During the COVID-19 Outbreak A Cohort Study From the Madrid Stroke Network
Blanca Fuentes, María Alonso de Leciñana, Sebastián García-Madrona, Fernando Díaz-Otero, Clara Aguirre, Patricia Calleja, José A. Egido, Joaquín Carneado-Ruiz, Gerardo Ruiz-Ares, Jorge Rodríguez-Pardo, Ángela Rodríguez-López, Álvaro Ximénez-Carrillo, Alicia de Felipe, Fernando Ostos, Guillermo González-Ortega, Patricia Simal, Carlos I. Gómez Escalonilla, Pablo Gómez-Porro-Sánchez, Zayrho Desanvicente, Gemma Reig, Antonio Gil-Núñez, Jaime Masjuán, Exuperio Díez-Tejedor.
CLINICAL AND POPULATION SCIENCES

Stroke  2021 Jan;52(2):552-562. doi: 10.1161/STROKEAHA.120.031769. Epub 2021 Jan 7

Tlr2 Gene Deletion Delays Retinal Degeneration in Two Genetically Distinct Mouse Models of Retinitis Pigmentosa

Translational Interdisciplinary Science-Immune Cell Niches: Possible Targets for Stroke Therapy?

Synthesis, Neuroprotection, and Antioxidant Activity of 1,1'-Biphenylnitrones as α-Phenyl- N-tert-butylnitrone Analogues in In Vitro Ischemia Models

Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges

Expanding the clinical and genetic spectrum of SQSTM1-related disorders in family with personality disorder and frontotemporal dementia

CdSe Quantum Dots in Human Models Derived from ALS Patients: Characterization, Nuclear Penetration Studies and Multiplexing

Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca²⁺ homeostasis and network synchrony via PMCA2/ATP2B2

Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson-Gilford Progeria Syndrome

Chemistry for the Identification of Therapeutic Targets: Recent Advances and Future Directions

Small-Molecule Therapeutic Perspectives for the Treatment of Progeria

Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery

The cannabinoid WIN55212-2 suppresses effector T-cell responses and promotes regulatory T cells in human tonsils

Self-Adaptation of Pseudomonas fluorescens Biofilms to Hydrodynamic Stress