PUBLICACIONES 2014:

Changes in CB1 and CB2 receptors in the post-mortem cerebellum of humans affected by spinocerebellar ataxias

Carmen Rodríguez-Cueto, Cristina Benito, Javier Fernández-Ruiz, Julián Romero, Mariluz Hernández-Gálvez y María Gómez-Ruiz.

Br J Pharmacol   2014 Mar  171(6):1472-89

Changes in Endocannabinoid Receptors and Enzymes in the Spinal Cord of SOD1G93A Transgenic Mice and Evaluation of a Sativex_-like Combination of Phytocannabinoids: Interest for Future Therapies in Amyotrophic Lateral Sclerosis

Miguel Moreno-Martet, Francisco Espejo-Porras, Javier Fernández-Ruiz y Eva de Lago.

CNS Neurosci Ther  2014 Sep  20(9):809-15

Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results

Cristina Fernández-Fernández, Luis F Callado, Rocío Girón, Eva Sánchez, Amaia M Erdozain, José Antonio López-Moreno, Paula Morales, Fernando Rodríguez de Fonseca, Javier Fernández-Ruiz, Pilar Goya, J Javier Meana, M. Isabel Martín y Nadine Jagerovic.

Drug Des Devel Ther  2014 Feb 20;8:263-77

Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer’s disease

Pedro González-Naranjo, Natalia Pérez-Macias, Nuria E. Campillo, Concepción Pérez, Vicente J. Arán, Rocio Girón, Eva Sánchez-Robles, María Isabel Martín, María Gómez-Cañas, Moisés García-Arencibia, Javier Fernández-Ruiz y Juan A. Páez.

European Journal of Medicinal Chemistry 73 (2014) 56-72

Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders

Orrin Devinsky, Maria Roberta Cilio, Helen Cross, Javier Fernández-Ruiz, Jacqueline French, Charlotte Hill, Russell Katz, Independent Consultant, Vincenzo Di Marzo, Didier Jutras-Aswad, William George Notcutt, José Martínez-Orgado, Philip J. Robson, Brian G. Rohrback, Elizabeth Thiele, Benjamin Whalley y Daniel Friedman.

Epilepsia, 55(6):791–802, 2014

Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling*

Estefanía Moreno, Clara Andradas, Mireia Medrano, María M. Caffarel, Eduardo Pérez-Gómez, Sandra Blasco-Benito, María Gómez-Cañas, M. Ruth Pazos, Andrew J. Irving, Carme Lluís, Enric I. Canela, Javier Fernández-Ruiz, Manuel Guzmán, Peter J. McCormick y Cristina Sánchez.

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 32, pp. 21960–21972, August 8, 2014

Early decrease of type 1 cannabinoid receptor binding and phosphodiesterase 10A activity in vivo in R6/2 Huntington mice

Maarten Ooms, Roma Rietjens, Janaki Raman Rangarajan, Kathleen Vunckx, Sara Valdeolivas, Frederik Maes, Uwe Himmelreich, Javier Fernández-Ruiz, Guy Bormans, Koen Van Laere y Cindy Casteels.

Neurobiology of Aging 35 (2014) 2858-2869

Endocannabinoid-Hydrolysing Enzymes in the Post-Mortem Cerebellum of Humans Affected by Hereditary Autosomal Dominant Ataxias

Carmen Rodríguez-Cueto, Cristina Benito, Julián Romero, Mariluz Hernández-Gálvez, María Gómez-Ruiz, Javier Fernández-Ruiz.

Pathobiology 2014  81:149–159

A restricted population of CB1 cannabinoid receptors with neuroprotective activity

Anna Chiarlone, Luigi Bellocchio, Cristina Blázquez, Eva Resel, Edgar Soria-Gómez, Astrid Cannich, José J. Ferrero, Onintza Sagredo, Cristina Benito, Julián Romero, José Sánchez-Prieto, Beat Lutzh, Javier Fernández-Ruiz, Ismael Galve-Roperh y Manuel Guzmán.

Proc Natl Acad Sci USA   2014 Jun 3  111(22):8257-62

Basal low antioxidant capacity correlates with cognitive deficits in early onset psychosis. A 2-year follow-up study

Mónica Martínez-Cengotitabengoa, Juan Antonio Micó, Celso Arango, Josefina Castro-Fornieles, Montserrat Graell, Beatriz Payá, Juan Carlos Leza, Iñaki Zorrilla, Mara Parellada, Mª. Purificación López, Inmaculada Baeza, Carmen Moreno, Marta Rapado-Castro, Ana González-Pinto.

Schizophrenia Research 156 (2014) 23–29

Regulatory role of the cannabinoid CB2 receptor in stress-induced neuroinflammation in mice

S. Zoppi, J. L. Madrigal, J. R. Caso, M. S. García-Gutiérrez, J. Manzanares, J. C. Leza y B. García-Bueno.

British Journal of Pharmacology (2014) 171 2814–2826

Pro-/antiinflammatory dysregulation in early psychosis: results from a 1-year follow-up study

Borja García-Bueno ¹, Miquel Bioque ¹, Karina S MacDowell ¹, Javier Santabárbara ¹, Mónica Martínez-Cengotitabengoa ¹, Carmen Moreno ¹, Pilar A Sáiz ¹, Esther Berrocoso ¹, Patricia Gassó ¹, M Fe Barcones ¹, Ana González-Pinto ¹, Mara Parellada ¹, Julio Bobes ¹, Juan A Micó ¹, Miguel Bernardo ¹, Juan C Leza ², FLAMM-PEPs study, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain

Int J Neuropsychopharmacol  2014 Oct 31;18(2):pyu037

The chemokine (C-C motif) ligand 2 in neuroinflammation and neurodegeneration

José L. M. Madrigal y Javier R. Caso.

Adv Exp Med Biol 2014  824: 209-19

Noradrenergic regulation of glial activation: molecular mechanisms and therapeutic implications

David Braun, Jose L M Madrigal y Douglas L Feinstein. 

Curr Neuropharmacol  2014 Jul  12(4):342-52

Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress

Iciar Gárate, Borja García-Bueno, José Luis Muñoz Madrigal, Javier R Caso, Luis Alou, María Luisa Gómez-Lus y Juan Carlos Leza.

Gárate et al. Journal of Neuroinflammation 2014, 11:8

Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study

Aldo Córdova-Palomera, Silvia Alemany, Mar Fatjó -Vilas, Ximena Goldberg, Juan Carlos Leza, Ana González-Pinto, Igor Nenadic y Lourdes Fañanas.

Plos One   2014 Aug 29;9(8):e103639

Characterisation of Gcf2/Lrrfip1 in experimental cerebral ischaemia and its role as a modulator of Akt, mTOR and β-catenin signalling pathways

Carme Gubern, Susanna Camós, Olivia Hurtado, Rocío Rodríguez, Víctor G. Romera, Mónica Sobrado, Roberto Cañadas, María A. Moro, Ignacio Lizasoain, Joaquín Serena, Judith Mallolas y Mar Castellanos.

Toll-like receptor 4 modulates cell migration and cortical neurogenesis after focal cerebral ischemia

Ana Moraga, Jesús M. Pradillo, María I. Cuartero, Macarena Hernández-Jiménez, Marta Oses, María A. Moro y Ignacio Lizasoain.

The FASEB Journal 2014 Nov   28(11):4710-8

Surgical manipulation compromises leukocy temobilization responses and inflammation after experimental cerebral ischemia in mice

Adam Denes, Jesús M Pradillo, Caroline Drake, Hannah Buggey, Nancy J. Rothwell y Stuart M. Allan.

Frontiers in Neuroscience   January  2014  Volume7 17 Article 271

Intravenous Immunoglobulin Promotes Antitumor Responses by Modulating Macrophage Polarization

Bruhns, Silvia Sánchez-Ramón and Angel L. Corbí Castrillo, David Sancho, Carmen Sánchez-Torres, Pierre María L. Toribio, María A. Moro, Isabel Cuartero, Antonio Enrique Martín-Gayo, Nico van Rooijen, Pedro Berraondo, Bragado, José Medina-Echeverz, Laura Aragoneses-Fenoll, Angeles Domínguez-Soto y Mateo de las Casas-Engel.

J Immunol published online  2014 Nov 15;193(10):5181-9

Apoptosis-related proteins are potential markers of neonatal hypoxic–ischemic encephalopathy (HIE) injury

Macarena Hernández-Jiménez, Silvia Sacristán, Carmen Morales, Mercedes García-Villanueva, Eugenia García-Fernández, Alberto Alcázar, Víctor M. González y M. Elena Martín.

Neuroscience Letters 558 (2014) 143– 148

The high-mobility group i-y transcription factor is involved in cerebral ischemia and modulates the expression of angiogenic proteins

S. Camos, C. Gubern, M. Sobrado, R. Rodríguez, V. G. Romera, M. A. Moro, I. Lizasoain, J. Serena, J. Mallolas y M. Castellanos.

Neuroscience 269 (2014) 112–130 

Oct-2 Transcription Factor Binding Activity and Expression Up-Regulation in Rat Cerebral Ischaemia is Associated with a Diminution of Neuronal Damage In Vitro

Susanna Camós, Carme Gubern, Mónica Sobrado, Rocío Rodríguez, Víctor G. Romera, María Ángeles Moro, Ignacio Lizasoain, Joaquín Serena, Judith Mallolas y Mar Castellanos.

Neuromol Med (2014) 16:332–349

Neutrophils scan for activated platelets to initiate inflammation

Vinatha Sreeramkumar, José M. Adrover, Ivan Ballesteros, Maria Isabel Cuartero, Jan Rossaint, Izaskun Bilbao, Maria Nácher, Christophe Pitaval, Irena Radovanovic, Yoshinori Fukui, Rodger P. McEver, Marie-Dominique Filippi, Ignacio Lizasoain,

Jesús Ruiz-Cabello, Alexander Zarbock, María A. Moro y Andrés Hidalgo.

Science   2014   Dec 5,346(6214):1234-8

Streptococcus pneumoniae Worsens Cerebral Ischemia via Interleukin 1 and Platelet Glycoprotein Iba

Adam Denes, Jesús M. Pradillo, Caroline Drake, Andrew Sharp, Peter Warn, Katie N. Murray, Bazaz Rohit, David H. Dockrell, Janet Chamberlain, Helen Casbolt, Sheila Francis, Bernadett Martinec, Bernhard Nieswandt, Nancy J. Rothwell y Stuart M. Allan.

Ann Neurol  2014 May;75(5):670-83

CB1 Cannabinoid Receptor-Dependent Activation of mTORC1/Pax6 Signaling Drives Tbr2 Expression and Basal Progenitor Expansion in the Developing Mouse Cortex

Javier Díaz-Alonso, Tania Aguado, Adán de Salas-Quiroga, Zaira Ortega, Manuel Guzmán y Ismael Galve-Roperh.

Cerebral Cortex Advance Access published March 7, 2014  

Programming of neural cells by (endo) cannabinoids: from physiological rules to emerging therapies

Mauro Maccarrone, Manuel Guzmán, Ken Mackie, Patrick Doherty y Tibor Harkany.

Nat Rev Neurosci   2014 Dec;15(12):786-801

The endocannabinoid system controls food intake via olfactory processes

Edgar Soria-Gómez, Luigi Bellocchio, Leire Reguero, Gabriel Lepousez, Claire Martin, Mounir Bendahmane, Sabine Ruehle, Floor Remmers, Tifany Desprez, Isabelle Matias, Theresa Wiesner, Astrid Cannich, Antoine Nissant, Aya Wadleigh, Hans-Christian Pape, Anna Paola Chiarlone, Carmelo Quarta, Daniéle Verrier, Peggy Vincent, Federico Massa, Beat Lutz, Manuel Guzmán, Hirac Gurden, Guillaume Ferreira, Pierre-Marie Lledo, Pedro Grandes y Giovanni Marsicano.

Nat Neurosci  2014 Mar;17(3):407-15

L-Kynurenine/Aryl Hydrocarbon Receptor Pathway Mediates Brain Damage After Experimental Stroke

María I. Cuartero, Iván Ballesteros, Juan de la Parra, Andrew L. Harkin, Aine Abautret-Daly, Eoin Sherwin, Pedro Fernández-Salguero, Ángel L. Corbí, Ignacio Lizasoain y María A. Moro.

Circulation   2014 Dec 2;130(23):2040-5

Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPAR_and 5-LO-dependent pathways

Iván Ballesteros, María I. Cuartero, Jesús M. Pradillo, Juan de la Parra, Alberto Pérez-Ruiz, Ángel Corbí, Mercedes Ricote, John A. Hamilton, Mónica Sobrado, José Vivancos, Florentino Nombela, Ignacio Lizasoain y María A. Moro.

Characterization of gcf2/lrrfip1 in experimental cerebral ischemia and its role as a modulator of akt, mtor and b-catenin signaling pathways

Gubern, S. Camos, O. Hurtado, R. Rodríguez, V. G. Romera, M. Sobrado, R. Cañadas, M. A. Moro, I. Lizasoain, J. Serena, J. Mallolas y M. Castellanos.

Neuroscience 268 (2014) 48–65

Serotonin 5‑HT6 Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer’s Disease

Bellinda Benhamú, Mar Martín-Fontecha, Henar Vázquez-Villa, Leonardo Pardo y María L. López-Rodríguez.

J Med Chem  2014 Sep 11;57(17):7160-81

Lanthanide-Chelating Carbohydrate Conjugates Are Useful Tools To Characterize Carbohydrate Conformation in Solution and Sensitive Sensors to Detect Carbohydrate−Protein Interactions

Ángeles Canales, Álvaro Mallagaray, M. Álvaro Berbís, Armando Navarro-Vázquez, Gema Domínguez, F. Javier Cañada, Sabine André, Hans-Joachim Gabius, Javier Pérez-Castells y Jesús Jiménez-Barbero.

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis**

Gloria Hernández-Torres, Maria Teresa Cipriano, Erika Hedn, Emmelie Bjçrklund, Ángeles Canales, Debora Zian, Ana Feliffl, Miriam Mecha, Carmen Guaza, Christopher J. Fowler, Silvia Ortega-Gutiérrez y María L. López-Rodríguez.

Angew Chem Int Ed Engl  2014 Dec 8;53(50)  13765-70

The Extracellular Entrance Provides Selectivity to Serotonin 5‑HT7 Receptor Antagonists with Antidepressant-like Behavior in Vivo

Rocío A. Medina, Henar Vázquez-Villa, José C. Gómez-Tamayo, Bellinda Benhamú, Mar Martín-Fontecha, Tania de la Fuente, Gianluigi Caltabiano, Peter B. Hedlund, Leonardo Pardo y María L. López-Rodríguez.

J Med Chem  2014 Aug 14;57(15)  6879-84

Current preclinical studies on neuroinflammation and changes in blood–brain barrier integrity by MDMA and methamphetamine

Esther O'Shea, Andrés Urrutia, A. Richard Green y M. Isabel Colado.

Neuropharmacology  2014 Dec;87  125-34

The Nitric Oxide Donor SNAP-Induced Amino Acid Neurotransmitter Release in Cortical Neurons. Effects of Blockers of Voltage-Dependent Sodium and Calcium Channels

José Joaquín Merino, Carmen Arce, Ahmad Naddaf, Víctor Bellver-Landete, María Jesús Oset- Gasque y María Pilar González.

Plos One 2014 Mar 5;9(3):e90703

Antioxidant and protective mechanisms against hypoxia and hypoglycaemia in cortical neurons in vitro

José Joaquín Merino, César Roncero, María Jesús Oset-Gasque, Ahmad Naddaf, María Pilar González.

Int J Mol Sci   2014 Feb 12;15(2)  2475-93

Toxicological and pharmacological evaluation, antioxidant, ADMET and molecular modeling of selected racemic chromenotacrines {11- amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3- ols} for the potential prevention and treatment of Alzheimer’s disease

María Jesús Oset-Gasque, María Pilar González, Javier Pérez-Peña, Nuria García-Font, Alejandro Romero, Javier del Pino, Eva Ramos, Dimitra Hadjipavlou-Litina, Elena Soriano, Mourad Chioua, Abdelouahid Samadi, Dushyant S. Raghuvanshi, Krishna N. Singh, José Marco-Contelles.

European Journal of Medicinal Chemistry 74 (2014) 491-501

Glutamate triggers neurosecretion and apoptosis in bovine chromaffin cells through a mechanism involving NO production by neuronal NO synthase activation

R. Pérez-Rodríguez, A.M. Oliván, C. Roncero, J. Morón-Oset, M.P. González, M.J. Oset-Gasque

Free Radical Biology and Medicine 69 (2014) 390–402