INNATE IMMUNITY (TLR4) AND STROKE

- Study of the cerebral damage and infiltration of peripheral cells (Circulation 2007; Stroke 2008; J Neurochem 2009; JCBFM 2016; Stroke 2019).

- Study of the adverse reactions of t-PA treatment such as haemorrhagic transformation (Stroke 2017) or t-PA-resistance (Stroke 2019).

- Study of new drugs acting on TLR4 (Mol Ther 2018)

- Study of the involvement of TLR4 on neurogenesis (FASEB J 2014; Brain Behav Imm 2019)

VASCULAR COGNITIVE IMPAIRMENT

- Study of hippocampal neurogenesis on cognitive vascular impairment after stroke (J Clin Invest 2019).

- Effect of modulation of Aryl hydrocarbon receptor (AhR) on hippocampus-dependent memory (eNeuro 2018)

- Effect of AhR on aging (FASEB J 2019)

ROLE OF NEUTROPHILS ON STROKE

- Role of neutrophil polarization in stroke (Stroke 2013; Stroke 2019)

- Neutrophil-platelet interaction on stroke (Science 2014)

- Neutrophil timer coordinates protection (Immunity 2019; Nature Immunol 2020)

NEUROGENESIS AND STROKE

- Study of SVZ neurogenesis after stroke (FASEB J 2014; J Neuroinflamm 2015; Sci Rep 2017; BBI 2019)

- Study of hippocampal neurogenesis after stroke (eNeuro 2018; J Clin Invest 2019)

- Effect of cannabinoid and TLR4 receptors on neurogenesis (Stroke 2010; FASEB J 2014; Stroke 2017; BBI 2019)

NEW TARGETS FOR STROKE THERAPY

- Nuclear Receptors and stroke: PPARgamma (JCBFM 2006, 2007; J Neurosci 2009; Stroke 2013; J Leukoc Biol 2014) and LXR (Circulation 2008)

- AhR and stroke (Circulation 2014; FASEB J 2019)

- IL1Ra yn stroke (Ann Neurol 2014; JCBFM 2016; BBI 2017)

- Cannabinoid receptors and stroke (Ped Res 2007; Stroke 2010, 2012, 2017)

HEMORRHAGIC TRANSFORMATION (HT)

- Effect of iron on HT at basic (Stroke 2018) and clinical level (Stroke 2007).

- Role of TLR4 on HT (Stroke 2017)

- Clinical biomarkers of HT: microalbuminuria (Neurology 2006) and MMP9 levels (Stroke 2003)

- Establishment of animal models of HT (Stroke 2016; Stroke 2011)

EXCITOTOXICITY (GLUTAMATE)

- Mechanisms of excitotoxicity in stroke (FASEB J 2003; Radiology 2013; J Clin Invest 2013)

- Glutamate transporters (EAAT2) and excitotoxicity (J Neurosci 2004; J Exp Med 2006; JCBFM 2007; Stroke 2016)

ISCHEMIC TOLERANCE AND STROKE

- Study of the role of PPARgamma on ischemic tolerance (IT) and preconditioning (PCI) (JCBFM 2007)

- Study of the TACE/TNFalpha/TNFRs pathway on IT and PCI (JCBFM 2002a, 2002b; Ann Neurol 2003; J Neurosci 2004; JCBFM 2005)

- Study of the role of TLR4 on IT and PCI (J Neurochem 2009)

OTHER RESEARCH LINES

- Risk factors on stroke (metabolic syndrome, hypertension, lipidemia/statins)(Stroke 2007; Neurology 2006, 2007; FASEB 2019)

- Neuroprotective drugs: citicoline (Neurobiol Dis 2005, 2007, 2008; J Neurochem 2013), aspirin (Neuropharmacology 2000; J Neurochem 2001; Stroke 2002; Neurosci Lett 2003)

- Nitric oxide and stroke (Eur J Neurosci 1998; J Neurochem 1999; Neuropharmacology 1999; J Neurochem 2000; JCBFM 2003)