Institutos Universitarios

Papers

PAPERS

In vitro antiamyloidogenic properties of 1,4-naphthoquinones.

Bermejo-Bescós, P.; Martín-Aragón, S.; Jiménez-Aliaga, K. L.; Ortega, A.; Molina, M. T.;  Buxaderas, E.; Orellana, G.; Csákÿ, A. G. Biochem. Biophys. Res. Commun. 2010, 400, 169.

Synthesis and evaluation of arylquinones as BACE1 inhibitors, β-amyloid peptide aggregation inhibitors, and destabilizers of preformed β-amyloid fibrils.

Ortega, A.; Rincón, A.; Jiménez-Aliaga, K. L.; Bermejo-Bescós, P.; Martín-Aragón, S.; Molina, M. T.; Csákÿ, A. G. Bioorg. Med. Chem. Lett. 2011, 21, 2183.

Regioselective 1,6-conjugate addition of boronic acids and Grignard reagents to dienylpyridines.

Roscales, S.; Salado, I. G.; Csákÿ, A. G. Synlett 2011, 2234.

Trifluoroacetic anhydride-catalyzed conjugate addition of boronic acids to α,β-unsaturated ketones.

Roscales, S.; Rincón, A.; Buxaderas, E.; Csákÿ, A. G. Tetrahedron Lett. 2012, 53, 4724.

Trifluoroacetic anhydride promoted tandem conjugate addition of boronic acids/acetal ring opening.

Roscales, S.; Csákÿ, A. G. Org. Lett. 2012, 14, 1187.

Pd(II)-catalyzed conjugate addition of boronic acids to ketoglutaconic esters toward the synthesis of functionalyzed pyridazin-3(2H)-ones with neuroprotective activity.

Roscales, S.; Ortega, A.; Martín-Aragón, S.; Bermejo-Bescós, P.; Csákÿ, A. G. Eur. J. Org. Chem. 2012, 5398.

Stereoselective synthesis of indanylglycine derivatives by a tandem Michael – Michael reaction.

Rincón, A.; Carmona, V.; Torres, M. R.; Csákÿ, A. G. Synlett 2012, 23, 2656.

Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer´s disease.

Jiménez-Aliaga, K.; Bermejo-Bescós, P .; Martín-Aragón, S.; Csákÿ, A. G. Bioorg. Med. Chem. Lett. 2013, 23, 426.

Metal free reactions of boronic acids: 1,3-Stereochemical induction in the substrate-controlled conjugate addition. 

Roscales, S.; Ortega, V.; Csákÿ, A. G. J. Org. Chem. 2013, 78, 12830.

Metal-free ring-opening of epoxides with potassium trifluoroborates.

Roscales, S.; Csákÿ, A. G. Chem. Commun. 2014, 50, 454.

1,2-Stereochemical Induction in the PdII-Catalyzed Conjugate Addition of Boronic Acids.

Roscales, S.; Sánchez, F.; Csákÿ, A. G. Eur. J. Org. Chem. 2015, 1754.

Transition-Metal-Free Direct anti-Carboboration of Alkynes with Boronic Acids to Produce Alkenylheteroarenes.

Roscales, S.; Csákÿ, A. G. Org. Lett. 2015, 17, 1605.

Metal-Free Conjugate Addition of Alkenylboronic Acids to Enedicarbonyl Compounds towards the Synthesis of Pyridazine Derivatives.

Roscales, S.; Sancho, A.; Csákÿ, A. G. Synthesis 2015, 47, 2233 (Special Issue focused on Conjugate Addition Methods, Invited Contribution by Editor, Prof. E. M. Carreira). 

Transition-metal Free reactions of boronic acids: Cascade addition – ring-opening of furans towards functionalized γ-Ketoaldehydes.

Roscales, S.; Csákÿ, A. G. Chem. Commun. 2016, 52, 3018

Synfacts 2016, 12, 0402 

Ring-opening of donor-acceptor cyclopropanes by boronic acids and potassium organotrifluoroborates under transition-metal-free conditions.

Ortega, V.; Csákÿ, A. G. J. Org. Chem. 2016, 81, 3917

Transition Metal-Free Stereocomplementary Cross-Coupling of Diols with Boronic Acids as Nucleophiles

Ortega, V.; del Castillo, E.; Csákÿ, A. G. Org. Lett. 2017, 29, 6236

Towards understanding the behavior of polyelectrolyte – surfactant mixtures at the water / vapor interface closer to technologically-relevant conditions

Llamas, S.; Akkano, A.; Fernández-Peña, L.; Guzmán, E.; Ortega, F.; Csáky, A. G.; Ortega, V.; Campbell, R. A.; Miller, R.; Rubio, R. G. Phys. Chem. Chem. Phys. 2018, 20, 1395.

Synthesis of Di(hetero)arylamines from Nitrosoarenes and Boronic Acids: A General, Mild, and Transition-Metal-Free Coupling

Roscales, S; Csákÿ, A. G. Org. Lett. 2018, 20, 1667

Organic Chemisty Portal

Selective Functionalization of Achmatowicz Rearrangement Products by Reactions with Potassium Organotrifluoroborates under Transition-Metal-Free Conditions

Roscales, S; Ortega, V.; Csákÿ, A. G.  J. Org. Chem. 201883, 11425

Organic Chemisty Portal

Synthesis of Mono-N-Methyl Aromatic Amines from Nitroso Compounds and Methylboronic Acid

Roscales, S; Csákÿ, A. G.  ACS OMEGA 2019, 4, 13943

Transition-Metal-Free Three-Component Synthesis of Tertiary Aryl Amines from Nitro Compounds, Boronic Acids, and Trialkyl Phosphites

Roscales, S; Csákÿ, A. G.  Adv.Synth. Catal. 2020, 362, 111 

Synthesis of Ketones by C-H Functionalization of Aldehydes with Boronic Acids under Transition-Metal-Free Conditions

Roscales, S; Csákÿ, A. G. Angew. Chem. Int. Ed. 2021, 60, 8728

Transition-metal-free Reductive Coupling of an 18F-Labeled Nitroarene with Boronic Acids as a Potential Access to 18F-Labeled Fenamates

Laube, M.; Roscales, S; Pietzsch, J.; Csákÿ, A. G.  Nucl.Med.Biolol. 2021, 96-97, S74

 

ORGANIC CHEMISTY PORTAL CITATIONS

 

REVIEWS

Naturally occurring δ-hydroxy-lactones: Muricatacins and related compounds

Murcia, M.C.; Navarro, C.; Moreno, A.; Csákÿ, A. G. Current Organic Chemistry, 2010, 14, 15

Conjugate Addition Reactions of Carbon Nucleophiles to Electron-deficient Dienes.

Csákÿ, A. G.; de la Herrán, G.; Murcia, M. C. Chem. Soc. Rev. 2010, 39, 4080.

1,2-Bis(diphenylphosphino)benzene.

Csákÿ, A. G.; Molina, M. T.  Electronic encyclopedia of reagents for organic synthesis (EROS).

Transition-metal-free C–C Bond-forming Reactions of Aryl, Alkenyl and Alkynylboronic Acids and their Derivatives.

Roscales, S.; Csákÿ, A. G. Chem. Soc. Rev. 2014, 43, 8215.

C–C Bond Formation with Boronic Acids and Derivatives by Transition-metal-free Conjugate Addition Reactions. 

Csákÿ, A. G., Sánchez-Sancho, F. Synthesis 201648, 2165.

How to Make C–N Bonds Using Boronic Acids and their Derivatives without Transition Metals

Roscales, S; Csákÿ, A. G.  Chem. Soc. Rev. 2020, 49, 5159  doi.org/10.1039/c9cs00735k

 

CHEMICAL EDUCATION

Synthesis of Flufenamic Acid: An Organic Chemistry Lab Sequence using Boronic Acids and Nitrosoarenes under Transition-Metal-Free Conditions

Roscales, S; Csákÿ, A. G.  J. Chem. Educ. 2019, 96, 1738

 

CONGRESSES

Development of New Transition-Metal-Free C-N and C-C Bond-Forming Reactions of Boronic Acids (poster)

Silvia Roscales, Víctor Ortega, Francisco Sánchez-Sancho, Aurelio G. Csákÿ*

XXVII Biennial Meeting in Organic Chemistry, Santiago de Compostela (Spain), 20 - 22 June, 2018

Development of new 18F-PET radiotracers for in vivo diagnose of tauopathies. Synthesis of new candidates and SPR affinity studies (poster)

Gracia Baquero Gálvez, A. M. González Fuente, F. Sánchez-Sancho,* Aurelio G. Csäky*

XXVII Biennial Meeting in Organic Chemistry, Santiago de Compostela (Spain), 20 - 22 June, 2018

Development of New Transition-Metal-Free C-N Bond-Forming Reactions of Boronic Acids: Synthesis of Amines (Oral presentation)

Silvia Roscales*, Aurelio G. Csaky

XXXVII Reunión Bienal de la Real Sociedad Española de Química, San Sebastián (Spain),  26 - 30 May, 2019

Transition-metal-free reductive coupling of an 18F-labeled nitro-arene with boronic acids as a potential access to 18F-labeled fenamates (poster + short explainer video)

Markus Laube,* Silvia Roscales, Jens Pietzsch, Aurelio G. Csáky

eSRS 2021 Virtual Meeting, Society of Radiopharmaceutical Sciences, 17 - 19 May, 2021