Institutos Universitarios

Mecanismos moleculares de SARS-CoV-2 e importancia de ECA2

Hoffmann et al. SARS-CoV-Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020 Mar 4. pii: S0092-8674(20)30229-4. doi: 10.1016/j.cell.2020.02.052. https://www.ncbi.nlm.nih.gov/pubmed/32142651

Shang et al. Structural basis of receptor recognition by SARS-CoV-2. Nature. 2020 Mar 30. doi: 10.1038/s41586-020-2179- y.  https://www.ncbi.nlm.nih.gov/pubmed/32225175

Lan et al. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature. 2020 Mar 30. doi: 10.1038/s41586-020-2180-5. https://www.ncbi.nlm.nih.gov/pubmed/32225176

Ou et al. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat Commun. 2020 Mar 27;11(1):1620. doi: 10.1038/s41467-020-15562-9. https://www.ncbi.nlm.nih.gov/pubmed/32221306