Grupos de investigación

ARTICULOS DE INVESTIGACIÓN

Ortiz-Sánchez P, González-Soto S, Villamizar LH, Valencia J, Jiménez E, Sacedón R, Ramírez M, Fariñas I, Varas A, Fernández-Sevilla LM, Vicente Á. Meningeal leukaemic aggregates as foci of cell expansion and chemoresistance in acute lymphoblastic leukaemia metastasis. Cell Oncol (Dordr). 2025 Jun;48(3):725-741. doi: 10.1007/s13402-025-01043-y. Epub 2025 Feb 12. PMID: 39937211; PMCID: PMC12119772.

Quintana-Castanedo L, Maseda R, Pérez-Conde I, Butta N, Monzón-Manzano E, Acuña-Butta P, Crespo MG, Buño-Soto A, Jiménez E, Valencia J, Arriba MC, Zuluaga P, de Lucas R, Del Río M, Vicente Á, Escámez MJ, Sacedón R. Interplay between iron metabolism, inflammation, and EPO-ERFE-hepcidin axis in RDEB-associated chronic anemia. Blood Adv. 2025 May 13;9(9):2321-2335. doi: 10.1182/bloodadvances.2024015271. PMID: 40036737; PMCID: PMC12127647.

Valencia J, Yáñez RM, Muntión S, Fernández-García M, Martín-Rufino JD, Zapata AG, Bueren JA, Vicente Á*, Sánchez-Guijo F* (Contributed equally). Improving the therapeutic profile of MSCs: Cytokine priming reduces donor-dependent heterogeneity and enhances their immunomodulatory capacity. Front Immunol. 2025 Feb 17;16:1473788. doi: 10.3389/fimmu.2025.1473788. PMID: 40034706; PMCID: PMC11872697.

Jiménez E, Vázquez A, González S, Sacedón R, Fernández-Sevilla LM, Varas A, Subiza JL, Valencia J, Vicente Á. Mucosal Bacterial Immunotherapy Attenuates the Development of Experimental Colitis by Reducing Inflammation Through the Regulation of Myeloid Cells. Int J Mol Sci. 2024 Dec 20;25(24):13629. doi: 10.3390/ijms252413629. PMID: 39769391; PMCID: PMC11728189.

Quintana-Castanedo L, Sánchez-Ramón S, Maseda R, Illera N, Pérez-Conde I, Molero-Luis M, Butta N, Arias-Salgado EG, Monzón-Manzano E, Zuluaga P, Martínez-Santamaría L, Fernández-Arquero M, Llames SG, Meana Á, de Lucas R, Del Río M, Vicente Á, Escámez MJ, Sacedón R. Unveiling the value of C-reactive protein as a severity biomarker and the IL4/IL13 pathway as a therapeutic target in recessive dystrophic epidermolysis bullosa: A multiparametric cross-sectional study. Exp Dermatol. 2024 Aug;33(8):e15146. doi: 10.1111/exd.15146. PMID: 39075828; PMCID: PMC11605501.

Sacedón R, de Arriba MC, Martínez-Santamaría L, Maseda R, Herráiz-Gil S, Jiménez E, Rosales I, Quintana L, Illera N, García M, Butta N, Fernández-Bello I, Lwin SM, Fernández-Arquero M, León C, McGrath JA, Vicente MÁ, Del Río M, de Lucas R, Sánchez-Ramón S, Escámez MJ. Gluten-sensitive enteropathy in recessive dystrophic epidermolysis bullosa. Br J Dermatol. 2023 Nov 16;189(6):774-776. doi: 10.1093/bjd/ljad313. PMID: 37655918.

Fernández-Sevilla LM, Valencia J, Ortiz-Sánchez P, Fraile-Ramos A, Zuluaga P, Jiménez E, Sacedón R, Martínez-Sánchez MV, Jazbec J, Debeljak M, Fedders B, Stanulla M, Schewe D, Cario G, Minguela A, Ramírez M, Varas A, Vicente Á. High BMP4 expression in low/intermediate risk BCP-ALL identifies children with poor outcomes. Blood. 2022 Jun 2;139(22):3303-3313. doi: 10.1182/blood.2021013506. PMID: 35313334; PMCID: PMC11022983.

Fernández-Sevilla LM, Belenguer G, Martí-Prado B, Ortiz-Sánchez P, Ramírez M, Varas A, Fariñas I, Vicente Á. Acute lymphoblastic leukemia cells are able to infiltrate the brain subventricular zone stem cell niche and impair neurogenesis. Haematologica. 2022 Apr 1;107(4):1004-1007. doi: 10.3324/haematol.2021.279383. PMID: 35045691; PMCID: PMC8968908.

Gómez-Ferrer M, Amaro-Prellezo E, Dorronsoro A, Sánchez-Sánchez R, Vicente Á, Cosín-Roger J, Barrachina MD, Baquero MC, Valencia J, Sepúlveda P. HIF-Overexpression and Pro-Inflammatory Priming in Human Mesenchymal Stromal Cells Improves the Healing Properties of Extracellular Vesicles in Experimental Crohn's Disease. Int J Mol Sci. 2021 Oct 19;22(20):11269. doi: 10.3390/ijms222011269. PMID: 34681929; PMCID: PMC8540690.

Vázquez A, Fernández-Sevilla LM, Jiménez E, Pérez-Cabrera D, Yañez R, Subiza JL, Varas A, Valencia J, Vicente A. Involvement of Mesenchymal Stem Cells in Oral Mucosal Bacterial Immunotherapy. Front Immunol. 2020 Nov 19;11:567391. doi: 10.3389/fimmu.2020.567391. PMID: 33329530; PMCID: PMC7711618.

Fernández-Sevilla LM, Valencia J, Flores-Villalobos MA, Gonzalez-Murillo Á, Sacedón R, Jiménez E, Ramírez M, Varas A, Vicente Á. The choroid plexus stroma constitutes a sanctuary for paediatric B-cell precursor acute lymphoblastic leukaemia in the central nervous system. J Pathol. 2020 Oct;252(2):189-200. doi: 10.1002/path.5510. Epub 2020 Aug 28. PMID: 32686161; PMCID: PMC7540040.

Valencia J, M Fernández-Sevilla L, Fraile-Ramos A, Sacedón R, Jiménez E, Vicente A, Varas A. Acute Lymphoblastic Leukaemia Cells Impair Dendritic Cell and Macrophage Differentiation: Role of BMP4. Cells. 2019 Jul 14;8(7):722. doi: 10.3390/cells8070722. PMID: 31337120; PMCID: PMC6679123.

Martínez VG, Rubio C, Martínez-Fernández M, Segovia C, López-Calderón F, Garín MI, Teijeira A, Munera-Maravilla E, Varas A, Sacedón R, Guerrero F, Villacampa F, de la Rosa F, Castellano D, López-Collazo E, Paramio JM, Vicente Á, Dueñas M. BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer. Clin Cancer Res. 2017 Dec 1;23(23):7388-7399. doi: 10.1158/1078-0432.CCR-17-1004. Epub 2017 Sep 19. PMID: 28928159.

Martinez VG, Ontoria-Oviedo I, Ricardo CP, Harding SE, Sacedon R, Varas A, Zapata A, Sepulveda P, Vicente A. Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells. Stem Cell Res Ther. 2017 Sep 29;8(1):208. doi: 10.1186/s13287-017-0659-2. PMID: 28962641; PMCID: PMC5622468.