Grupos de investigación


Publicaciones 2012-2023

Artículo: A; Revisión: R; Editorial: E.
IF: Impact Factor según JCR
Q: Cuartil según JCR (año de publicación, o del último año disponible, entre paréntesis)





Robescu, M.S.; Alcántara, A.R.; Calvio, C.; Morelli, C.F.; Speranza, G.; Ubiali, D.; Bavaro, T. L-Theanine Goes Greener: A Highly Efficient Bioprocess Catalyzed by the Immobilized γ-Glutamyl Transferase from Bacillus subtilis. ChemSusChem 2023, doi:10.1002/cssc.202202108.

Rios, N.S.; Cipolati, E.; Guimarães, J.R.; Tardioli, P.W.; Berenguer-Murcia, Á.; Rodrigues, R.C.; Alcántara, A.R.; Rocha-Martin, J.; Fernandez-Lafuente, R. Use of magnetic nanoparticles to build magnetic macro porous biocatalyst: prospects and trends. In Bionanocatalysis: From Design to Applications, Fernandez-Lafuente, R., Bilal, M., Iqbal, H.M., Nguyen, T.A., Eds.; Elsevier: The Boulevard Langford Lane, Oxford, UK. , 2023.

Khiari, O.; Bouzemi, N.; Sánchez-Montero, J.M.; Alcántara, A.R. On the Use of Orthoformates as an Efficient Approach to Enhance the Enzymatic Enantioselective Synthesis of (S)-Ibuprofen. Catalysts 202313, 251.

Guimarães, J.R.; Carballares, D.; Rocha-Martin, J.; Alcántara, A.R.; Tardioli, P.W.; Fernandez-Lafuente, R. Heterofunctional Methacrylate Beads Bearing Octadecyl and Vinyl Sulfone Groups: Tricks to Obtain an Interfacially Activated Lipase from Thermomyces lanuginosus and Covalently Attached to the Support. Catalysts 202313, 108, doi:10.3390/catal13010108.

da Rocha, T.N.; Morellon-Sterling, R.; Gonçalves, L.R.B.; Bolivar, J.M.; Alcántara, A.R.; Rocha-Martin, J.; Fernández-Lafuente, R. Synergy of Ion Exchange and Covalent Reaction: Immobilization of Penicillin G Acylase on Heterofunctional Amino-Vinyl Sulfone Agarose. Catalysts 202313, 151, doi:10.3390/catal13010151.

Aranaz, I., Acosta, N., Revuelta, J., Bastida, A., Gómez-Casado, V., Civera, C., . . . Doncel-Pérez, E. (2023). Fast and sustained axonal growth by BDNF released from chitosan microspheres. Marine Drugs, 21(2), 91. doi:
Aranaz,I; Navarro-García, F; Morri,M; Acosta,N. ; Casettari, L.   Heras,A. Evaluation of chitosan salt properties in the production of AgNPs materials with antibacterial activity, International Journal of Biological Macromolecules, Volume 235, 2023, 123849,



Serra, I.; Wilson, L.; Alcántara, A.R. Editorial: Recent Advances in Biocatalysis: Focusing on Applications of These Processes. Frontiers in Bioengineering and Biotechnology 202210, doi:10.3389/fbioe.2022.844741.

Miele, M.; Pillari, V.; Pace, V.; Alcántara, A.R.; de Gonzalo, G. Application of Biobased Solvents in Asymmetric Catalysis. Molecules 202227, doi:10.3390/molecules27196701.

Miele, M.; Ielo, L.; Pillari, V.; Fernández, M.; Alcántara, A.R.; Pace, V. Biomass-derived Solvents. In Sustainable Organic Synthesis: Tools and Strategies, Protti, S., Palmieri, A., Eds.; The Royal Society of Chemistry: Croydon, UK, 2022; pp. 239-279.

Miele, M.; Ielo, L.; Pace, V.; Alcántara, A.R. Biocatalysis in green biosolvents. In Greener synthesis of organic compounds, First edition. ed.; Nag, A., Ed.; CRC Press: Boca Raton, 2022.

de Gonzalo, G.; Alcántara, A.R.; Domínguez de María, P.; Sánchez-Montero, J.M. Biocatalysis for the asymmetric synthesis of Active Pharmaceutical Ingredients (APIs): this time is for real. Expert Opin. Drug Discov. 2022, 1-13, doi:10.1080/17460441.2022.2114453.

de Gonzalo, G.; Alcántara, A.R. Enzyme-catalyzed asymmetric synthesis. In Catalytic Asymmetric Synthesis, Fourth Edition, Akiyama, T., Ojima, I., Eds.; John Wiley & Sons, Inc.: 2022.

Alcántara, A.R.; Domínguez de María, P.; Littlechild, J.; Schürmann, M.; Sheldon, R.A.; Wohlgemuth, R. Biocatalysis as Key to Sustainable Industrial Chemistry. ChemSusChem 2022, e202102709, doi:10.1002/cssc.202102709.

Acinas, V.; Alberdi, A.; Alcántara, A.R.; al., e. Materials 2030 Roadmap; AMI2030, Advanced Materials 2030 Initiative: 2022.

Affes, S., Aranaz, I., Acosta, N. et al. Physicochemical and biological properties of chitosan derivatives with varying molecular weight produced by chemical depolymerization. Biomass Conv. Bioref. (2022).

Garcinuño, S., Aranaz, I., Civera, C., Arias, C., & Acosta, N. (2022). Evaluating non-conventional chitosan sources for controlled release of risperidone. Polymers, 14(7), 1355. doi:
Fernández-Villa, D., Ramírez-Jiménez, R. A., Aranaz, I., Acosta, N., Vázquez-Lasa, B., & Rojo, L. (2022). Development of methotrexate complexes endowed with new biological properties envisioned for musculoskeletal regeneration in rheumatoid arthritis environments. International Journal of Molecular Sciences, 23(17), 10054. doi:
Rodriguez-Veiga, I., Acosta, N., Aranaz, I., & Dobrzycka-Krahel, A. (2022). Exploring saduria entomon (crustacea isopoda) as a new source for chitin and chitosan isolation. International Journal of Molecular Sciences, 23(24), 16125. doi:



Alcántara, A.R.; Plou, F. J., Special Issue on “Applied Biocatalysis in Europe: A Sustainable Tool for Improving Life Quality”.

Catalysts 2021, 11 (3), 339. DOI: 10.3390/catal11030339

IF: 3.444 (2019)      E        Q2


Arana-Peña, S.; Carballares, D.; Morellon-Sterlling, R.; Berenguer-Murcia, Á.; Alcántara, A.R.; Rodrigues, R.C.; Fernandez-Lafuente, R.

Enzyme co-immobilization: Always the biocatalyst designers' choice…or not?

Biotech. Adv. 2021, i DOI: 10.1016/j.biotechadv.2020.107584

IF: 10.744 (2019)    R        Q1


Ielo, L.; Miele, M.; Pillari, V.; Senatore, R.; Mirabile, S.; Gitto, R.; Holzer, W.; Alcántara, A.R.; Pace, V.

Taking Advantage of Lithium Monohalocarbenoids Intrinsic α-Elimination in 2-MeTHF: Controlled Epoxide Ring-Opening en route to Halohydrins.

Org. Biomol. Chem. 2021, 19, 2038-2043, DOI: 10.1039/D0OB02407D

IF: 3.412 (2019)      A        Q1


Rabuffetti, M.; Cannazza, P.; Contente, M.L.; Pinto, A.; Romano, D.; Hoyos, P.; Alcántara, A.R.; Eberini, I.; Laurenzi, T.; Gourlay, L., et al.

Structural insights into the desymmetrization of bulky 1,2-dicarbonyls through enzymatic monoreduction.

Bioorg. Chem. 2021, 108, 104644, DOI: 10.1016/j.bioorg.2021.104644

IF: 4.831 (2019)      A        Q1


Monteiro, R.R.C.; Virgen-Ortiz, J.J.; Berenguer-Murcia, A.; da Rocha, T.N.; dos Santos, J.C.S.; Alcantara, A.R.; Fernandez-Lafuente, R.

Biotechnological relevance of the lipase A from Candida antarctica

Catal. Today 2021, 362, 141-154, DOI: 10.1016/j.cattod.2020.03.026

IF: 5.825 (2019)      R        Q1


Del Arco, J.; Alcántara, A.R.; Fernández-Lafuente, R.; Fernández-Lucas, J.

Magnetic Micro-Macro Biocatalysts applied to Industrial Bioprocesses.

Bioresour. Technol. 2021, 322, 124547, DOI: 10.1016/j.biortech.2020.124547

IF: 7.539 (2019)      R        Q1




Revuelta, J.; Aranaz, I.; Acosta, N.; Civera, C.; Bastida, A.; Pena, N.; Monterrey, D.T.; Doncel-Perez, E.; Garrido, L.; Heras, A., et al.

Unraveling the Structural Landscape of Chitosan-Based Heparan Sulfate Mimics Binding to Growth Factors: Deciphering Structural Determinants for Optimal Activity.

ACS Appl. Mater. Interfaces 2020, 12, 25534-25545, DOI: 10.1021/acsami.0c03074

IF: 8.758 (2019)      A        Q1


Affes, S.; Maalej, H.; Aranaz, I.; Acosta, N.; Heras, A.; Nasri, M.

Enzymatic production of low-Mw chitosan-derivatives: Characterization and biological activities evaluation

Int. J. Biol. Macromol. 2020, 144, 279-288, DOI: 10.1016/j.ijbiomac.2019.12.062

IF: 5.162 (2019)      A        Q1


Affes, S.; Maalej, H.; Aranaz, I.; Kchaou, H.; Acosta, N.; Heras, A.; Nasri, M.

Controlled size green synthesis of bioactive silver nanoparticles assisted by chitosan and its derivatives and their application in biofilm preparation.

Carbohydr. Polym. 2020, 236, DOI: 10.1016/j.carbpol.2020.116063

IF: 7.182 (2019)      A        Q1


Ramos-Martin, J.; Khiari, O.; Alcántara, A.R.; Sanchez-Montero, J.M.

Biocatalysis at Extreme Temperatures: Enantioselective Synthesis of both Enantiomers of Mandelic Acid by Transesterification Catalyzed by a Thermophilic Lipase in Ionic Liquids at 120 degrees C.

Catalysts 2020, 10, DOI: 10.3390/catal10091055

IF: 3.444 (2019)      A        Q2


Monteiro, R.R.C.; dos Santos, J.C.S.; Alcántara, A.R.; Fernandez-Lafuente, R.

Enzyme-Coated Micro-Crystals: An almost forgotten but very simple and elegant immobilization strategy.

Catalysts 2020, 10, 891, DOI: 10.3390/catal10080891

IF: 3.444 (2019)      R        Q2


Kornecki, J.F.; Carballares, D.; Tardioli, P.W.; Rodrigues, R.C.; Berenguer-Murcia, Á.; Alcántara, A.R.; Fernandez-Lafuente, R.

Enzyme production of D-gluconic acid and glucose oxidase: successful tales of cascade reactions.

Catal. Sci. Technol. 2020, 10, 5740-5771, DOI: 10.1039/D0CY00819B

IF: 5.724 (2019)      R        Q2


Arana-Peña, S.; Carballares, D.; Berenguer-Murcia, Á.; Alcántara, A.R.; Rodrigues, R.C.; Fernandez-Lafuente, R.

One pot use of combilipases for full modification of oils and fats: Multifunctional and heterogeneous substrates.

Catalysts 2020, 10(6), 605 DOI: 10.3390/catal10060605

IF: 3.444 (2019)      A        Q2


Civera, C;
Del Valle,J.C.; Elorza,MA; Elorza,B; Arias, C; Díaz-Oliva, C.; Catalán,J.; García Blanco F.

Solvatochromism in urea/water and urea-derivative/water solutions

Phys. Chem. Chem. Phys., 2020, 22, 25165-25176 DOI:10.1039/D0CP03816D (Paper)

 IF: 3.430 (2019) Q2




Rodrigues, R.C.; Virgen-Ortiz, J.J.; Dos Santos, J.C.S.; Berenguer-Murcia, A.; Alcántara, A.R.; Barbosa, O.; Ortiz, C.; Fernandez-Lafuente, R.

Immobilization of lipases on hydrophobic supports: immobilization mechanism, advantages, problems, and solutions.

Biotechnol. Adv. 2019, 37, 746-770


IF: 10.744     R        Q1


González, J.F.; Alcántara, A.R.; Doadrio, A.L.; Sánchez-Montero, J.M.

Developments with multi-target drugs for Alzheimer’s disease: an overview of the current discovery approaches.

Expert Opin. Drug. Discov. 2019, 14, 879-891, DOI: 10.1080/17460441.2019.1623201

IF: 4.887      R        Q1


Affes, S.; Aranaz, I.; Hamdi, M.; Acosta, N.; Ghorbel-Bellaaj, O.; Heras, A.; Nasri, M.; Maalej, H.

Preparation of a crude chitosanase from blue crab viscera as well as its application in the production of biologically active chito-oligosaccharides from shrimp shells chitosan.

Int. J. Biol. Macromol. 2019, 139, 558-569, DOI:10.1016/j.ijbiomac.2019.07.116

IF: 5.162      A        Q1


de Gonzalo, G.; Alcántara, A.R.; Domínguez de María, P.

Cyclopentyl-methyl ether (CPME): Versatile eco-friendly solvent for applications in Biotechnology and Biorefineries

ChemSusChem 2019, 12(10), 2083-2097, DOI: 10.1002/cssc.201900079

IF: 7.962      R        Q1


Aranaz, I.; Alcántara, A.R.; Heras, A.; Acosta, N.

Efficient reduction of Toluidine Blue O dye using silver nanoparticles synthesized by low molecular weight chitosans.

Int. J. Biol. Macromol. 2019, 131, 682-690, DOI:10.1016/j.ijbiomac.2019.03.119

IF: 5.162      A        Q1


Tacias-Pascacio, V.G.; Ortiz, C.; Rueda, N.; Berenguer-Murcia, A.; Acosta, N.; Aranaz, I.; Civera, C.; Fernandez-Lafuente, R.; Alcántara, A.R.

Dextran aldehyde in biocatalysis: More than a mere immobilization system.

Catalysts 2019, 9, 43, DOI: 10.3390/catal9070622

IF: 3.444      R        Q2


Tacias-Pascacio, V.G.; García-Parra, E.; Vela-Gutiérrez, G.; Virgen-Ortiz, J.J.; Berenguer-Murcia, Á.; Alcántara, A.R.; Fernandez-Lafuente, R.

Genipin as An Emergent Tool in the Design of Biocatalysts: Mechanism of Reaction and Applications.

Catalysts 2019, 9, 1035, DOI: 10.3390/catal9121035

IF: 3.444      R        Q2


Domínguez de María, P.; de Gonzalo, G.; Alcántara, A.R. Biocatalysis as useful tool in asymmetric synthesis: An assessment of recently granted patents (2014–2019).

Catalysts 2019, 9, 802, DOI: 10.3390/catal9100802

IF: 3.444      R        Q2


Alcántara, A.R. Biocatalysis and Pharmaceuticals: A Smart Tool for Sustainable Development.

Catalysts 2019, 9, 792, DOI: 10.3390/catal9100792

IF: 3.444      E        Q2

Peniche, H.; Acosta, N.; Aranaz, I.; García, L.; Bada, N.; Heras, A.; Peniche, C. Calcium cross-linked carboxymethylchitosan/alginate microparticles as a system for the prolonged release of ketoprofen.

Revista Cubana de Química 2019, 37-57.

IF:      A        no ranked




Aranaz, I.; Acosta, N.; Civera, C.; Elorza, B.; Mingo, J.; Castro, C.; Gandía, M.L.; Heras,  A.

Cosmetics and cosmeceutical applications of chitin, chitosan and their derivatives.

Polymers 2018, 10, DOI:10.3390/polym10020213

IF: 3.164      A        Q1


Sanchez, A.; Mengibar, M.; Fernandez, M.; Alemany, S.; Heras, A.; Acosta, N.

Influence of Preparation Methods of Chitooligosaccharides on Their Physicochemical Properties and Their Anti-Inflammatory Effects in Mice and in RAW264.7 Macrophages.

Marine Drugs 2018, 16, DOI:10.3390/md16110430

IF: 3.772      A        Q1



Benito-Arenas, R.; Doncel-Perez, E.; Fernandez-Gutierrez, M.; Garrido, L.; Garcia-Junceda, E.; Revuelta, J.; Bastida, A.; Fernandez-Mayoralas, A.

A holistic approach to unravelling chondroitin sulfation: Correlations between surface charge, structure and binding to growth factors.

Carbohydr. Polym.2018, 202, 211-218, DOI:10.1016/j.carbpol.2018.08.120

IF: 6.044      A        Q1


Doncel-Perez, E.; Ellis, G.; Sandt, C.; Shuttleworth, P.S.; Bastida, A.; Revuelta, J.; Garcia-Junceda, E.; Fernandez-Mayoralas, A.; Garrido, L.

Biochemical profiling of rat embryonic stem cells grown on electrospun polyester fibers using synchrotron infrared microspectroscopy.

Anal. Bioanal. Chem. 2018, 410, 3649-3660, DOI:10.1007/s00216-018-1049-z

IF: 3.286      A        Q1


Doncel-Perez, E.; Aranaz, I.; Bastida, A.; Revuelta, J.; Camacho, C.; Acosta, N.; Garrido, L.; Civera, C.; Garcia-Junceda, E.; Heras, A., et al.

Synthesis, physicochemical characterization and biological evaluation of chitosan sulfate as heparan sulfate mimics.

Carbohydr. Polym.2018, 191, 225-233, DOI:10.1016/j.carbpol.2018.03.036

IF: 6.044      A        Q1



Santos-Moriano, P.; Kidibule, P.E.; Alleyne, E.; Ballesteros, A.O.; Heras, A.; Fernandez-Lobato, M.; Plou, F.J.

Efficient conversion of chitosan into chitooligosaccharides by a chitosanolytic activity from Bacillus thuringiensis.

Process Biochem. 2018, 73, 102-108, DOI: 10.1016/j.procbio.2018.07.017

IF: 2.952      A        Q2


Garrido, L.; Aranaz, I.; Gallardo, A.; Garcia, C.; Garcia, N.; Benito, E.; Guzman, J.

Reply to "Comment on 'Ionic Conductivity, Diffusion Coefficients and Degree of Dissociation in Lithium Electrolytes, Ionic Liquids and Hydrogel Polyelectrolytes".

J. Phys. Chem. B 2018, 122, 10968-10969, DOI:10.1021/acs.jpcb.8b10603

IF: 2.923      A        Q2


Garrido, L.; Aranaz, I.; Gallardo, A.; Garcia, C.; Garcia, N.; Benito, E.; Guzman, J.

Ionic Conductivity, Diffusion Coefficients, and Degree of Dissociation in Lithium Electrolytes, Ionic Liquids, and Hydrogel Polyelectrolytes.

J. Phys. Chem. B 2018, 122, 8301-8308, DOI:10.1021/acs.jpcb.8b06424

IF: 2.923      A        Q2



Castoldi, L.; Ielo, L.; Hoyos, P.; Hernaiz, M.J.; De Luca, L.; Alcántara, A.R.; Holzer, W.; Pace, V.

Merging lithium carbenoid homologation and enzymatic reduction: A combinative approach to the HIV-protease inhibitor Nelfinavir.

Tetrahedron 2018, 74, 2211-2217, DOI:10.1016/j.tet.2018.03.034

IF: 2.379      A        Q2



Aranaz, I.; Acosta, N.; Heras, A.

Enzymatic D-p-hydrophenyl glycine synthesis using chitin and chitosan as supports for biocatalyst immobilization.

Biocatal. Biotransfor. 2018, 36, 89-101, DOI:10.1080/10242422.2017.1366991

IF: 1.627      A        Q3


Santos-Moriano, P.; Fernandez-Arrojo, L.; Mengibar, M.; Belmonte-Reche, E.; Peñalver, P.; Acosta, F.N.; Ballesteros, A.O.; Morales, J.C.; Kidibule, P.; Fernandez-Lobato, M., et al.

Enzymatic production of fully deacetylated chitooligosaccharides and their neuroprotective and anti-inflammatory properties.

Biocatal. Biotransform. 2018, 36, 57-67, DOI: 10.1080/10242422.2017.1295231

IF: 1.627      A        Q3


Alcántara, C.M.; Alcántara, A.R. Biocatalyzed synthesis of antidiabetic drugs: A review.

Biocatal. Biotransform. 2018, 36, 12-46, DOI:10.1080/10242422.2017.1323887

IF: 1.627      R        Q3


Alcántara, A.R.; Garcia-Junceda, E.; Gotor, V.; Plou, F.J. Biocatalysis in Spain: A field of success and innovation.

Biocatal. Biotransform. 2018, 36, 180-183, DOI:10.1080/10242422.2017.1420064

IF: 1.627      E        Q3


Alcántara, A.R.; Dominguez de Maria, P. Recent Advances on the Use of 2-methyltetrahydrofuran (2-MeTHF) in Biotransformations.

Curr. Green Chem. 2018, 5, 85-102, DOI:10.2174/2213346105666180727100924

IF:      R        no ranked


Alcántara, A.R. Biotransformations in Drug Synthesis: A Green and Powerful Tool for Medicinal Chemistry.

Med. Chem. Drug Des. 2018, 1, 1-7, DOI:10.16966/jmcdd.102

IF:      R        no ranked


Aranaz, I.; Castro, C.; Heras, A.; Acosta, N.

On the Ability of Low Molecular Weight Chitosan Enzymatically Depolymerized to Produce and Stabilize Silver Nanoparticles.

Biomimetics 2018, 3(3), 21, DOI:10.3390/biomimetics3030021

IF:      A        no ranked




Winkler, A.J.; Dominguez-Nuñez, J.A.; Aranaz, I.; Poza-Carrión, C.; Ramonell, K.; Somerville, S.; Berrocal-Lobo, M. Short-chain chitin oligomers: Promoters of plant growth.

Marine Drugs 2017, 15, DOI:10.3390/md15020040

IF: 4.379      A        Q1


Sánchez, Á.; Mengíbar, M.; Rivera-Rodríguez, G.; Moerchbacher, B.; Acosta, N.; Heras, A. The effect of preparation processes on the physicochemical characteristics and antibacterial activity of chitooligosaccharides.

Carbohydr. Polym.2017, 157, 251-257, DOI:10.1016/j.carbpol.2016.09.055

IF: 5.158      A        Q1


Mengíbar, M.; Miralles, B.; Heras, A. Use of soluble chitosans in Maillard reaction products with β-lactoglobulin. Emulsifying and antioxidant properties.

LWT-Food Sci. Technol. 2017, 75, 440-446, DOI:10.1016/j.lwt.2016.09.016

IF: 3.129      A        Q1


Martínez-Campos, E.; Civantos, A.; Redondo, J.A.; Guzmán, R.; Pérez-Perrino, M.; Gallardo, A.; Ramos, V.; Aranaz, I. Cell Adhesion and Proliferation on Sulfonated and Non-Modified Chitosan Films.

AAPS PharmSciTech 2017, 18, 974-982, DOI:10.1208/s12249-016-0619-7

IF: 2.666      A        Q2


Castejon, D.; Herrera, A.; Heras, A.; Cambero, I.; Mateos-Aparicio, I. Oil Quality Control of Culinary Oils Subjected to Deep-Fat Frying Based on NMR and EPR Spectroscopy.

Food Anal. Meth. 2017, 10, 2467-2480, DOI:10.1007/s12161-016-0778-x

IF: 2.245      A        Q2


Aranaz, I.; Paños, I.; Peniche, C.; Heras, A.; Acosta, N. Chitosan spray-dried microparticles for controlled delivery of venlafaxine hydrochloride.

Molecules 2017, 22, DOI:10.3390/molecules22111980

IF: 3.098      A        Q2


Aranaz, I.; Martínez-Campos, E.; Moreno-Vicente, C.; Civantos, A.; García-Arguelles, S.; del Monte, F. Macroporous calcium phosphate/chitosan composites prepared via unidirectional ice segregation and subsequent freeze-drying

Materials 2017, 10, DOI:10.3390/ma10050516

IF: 2.467      A        Q2


Peniche, C.J.; Peniche, H.; Bada, N.; Sáez, V.; Acosta, N.; Peniche, C.A. Design of a parenteral formulation for prolonged risperidone release based on an in situ gelification system.

Revista Cubana de Investigaciones Biomedicas 2017, 36,

IF:      A        no ranked



Mateos-Hernandez, L.; Villar, M.; Doncel-Perez, E.; Trevisan-Herraz, M.; Garcia-Forcada, A.; Romero Ganuza, F.; Vazquez, J.; de la Fuente, J. Quantitative proteomics reveals Piccolo as a candidate serological correlate of recovery from Guillain-Barre syndrome.

Oncotarget 2016, 7, 74582-74591, DOI:10.18632/oncotarget.12789

IF: 5.168      A        Q1


Mateos-Aparicio, I.; Mengibar, M.; Heras, A. Effect of chito-oligosaccharides over human faecal microbiota during fermentation in batch cultures.

Carbohydr. Polym.2016, 137, 617-624, DOI:10.1016/j.carbpol.2015.11.011

IF: 4.811      A        Q1


Hortigüela, M.J.; Yuste, L.; Rojo, F.; Aranaz, I. Green synthesis of hierarchically structured silver-polymer nanocomposites with antibacterial activity.

Nanomaterials 2016, 6, DOI:10.3390/nano6080137

IF: 3.553      A        Q2


Garcia-Junceda, E.; Bastida, A.; Doncel-Perez, E.; Montero-Calle, P.; Moreno-Zafra, V.; Garrido, L.; Revuelta, J.; Fernandez-Mayoralas, A. Chemoenzymatic preparation of chondroitin sulfates with a defined sulfation pattern.

New Biotech. 2016, 33, S43-S44, DOI:10.1016/j.nbt.2016.06.875

IF: 3.813      A        Q2


Fernández-de Castro, L.; Mengíbar, M.; Sánchez, Á.; Arroyo, L.; Villarán, M.C.; Díaz de Apodaca, E.; Heras, A. Films of chitosan and chitosan-oligosaccharide neutralized and thermally treated: Effects on its antibacterial and other activities.

LWT-Food Sci. Technol. 2016, 73, 368-374, DOI: 10.1016/j.lwt.2016.06.038

IF: 2.329      A        Q1


Doncel-Perez, E.; Nieto-Sampedro, M. Aldynoglia cells and modulation of RhoGTPase activity as useful tools for spinal cord injury repair.

Neural Regen. Res. 2016, 11, 1043-1045, DOI:10.4103/1673-5374.187020

IF: 1.769      A        Q4


Doncel-Perez, E.; Mateos-Hernandez, L.; Pareja, E.; Garcia-Forcada, A.; Villar, M.; Tobes, R.; Romero Ganuza, F.; Vila del Sol, V.; Ramos, R.; Fernandez de Mera, I.G., et al. Expression of Early Growth Response Gene-2 and Regulated Cytokines Correlates with Recovery from Guillain Barre Syndrome.

Immunol. 2016, 196, 1102-1107, DOI:10.4049/jimmunol.1502100

IF: 4.856      A        Q1


Aranaz, I.; Harris, R.; Navarro-García, F.; Heras, A.; Acosta, N. Chitosan based films as supports for dual antimicrobial release.

Carbohydr. Polym.2016, 146, 402-410, DOI:10.1016/j.carbpol.2016.03.064

IF: 4.811      A        Q1




Serrano-Perez, M.C.; Fernandez, M.; Neria, F.; Berjon-Otero, M.; Doncel-Perez, E.; Cano, E.; Tranque, P. NFAT Transcription Factors Regulate Survival, Proliferation, Migration, and Differentiation of Neural Precursor Cells.

Glia 2015, 63, 987-1004, DOI:10.1002/glia.22797

IF: 5.997      A        Q1


Jatunov, S.; Franconetti, A.; Prado-Gotor, R.; Heras, A.; Mengibar, M.; Cabrera-Escribano, F. Fluorescent imino and secondary amino chitosans as potential sensing biomaterials.

Carbohydr. Polym.2015, 123, 288-296, DOI:10.1016/j.carbpol.2015.01.061

IF: 4.219      A        Q1



Serra, I.; Daly, S.; Alcántara, A.R.; Bianchi, D.; Terreni, M.; Ubiali, D. Redesigning the synthesis of vidarabine via a multienzymatic reaction catalyzed by immobilized nucleoside phosphorylases.

RSC Advances 2015, 5, 23569-23577, DOI:10.1039/c4ra15018j

IF: 3.289      A        Q2


Pizzilli, A.; Zoppi, R.; Hoyos, P.; Gomez, S.; Gatti, F.G.; Hernaiz, M.J.; Alcántara, A.R. First stereoselective acylation of a primary diol possessing a prochiral quaternary center mediated by lipase TL from Pseudomonas stutzeri.

Tetrahedron 2015, 71, 9172-9176, DOI:10.1016/j.tet.2015.09.056

IF: 2.645      A        Q2


Sanchez-Sierra, M.; Garcia-Alvarez, I.; Fernandez-Mayoralas, A.; Moreno-Lillo, S.; Barroso Garcia, G.; Moral Darde, V.; Doncel-Perez, E. Mass Spectrometry in Pharmacokinetic Studies of a Synthetic Compound for Spinal Cord Injury Treatment.

Biomed. Res. Int. 2015, Article ID 169234, DOI:10.1155/2015/169234

IF: 2.134      A        Q3


Garcia-Alvarez, I.; Fernandez-Mayoralas, A.; Moreno-Lillo, S.; Sanchez-Sierra, M.; Nieto-Sampedro, M.; Doncel-Perez, E. Inhibition of glial proliferation, promotion of axonal growth and myelin production by synthetic glycolipid: A new approach for spinal cord injury treatment.

Restor. Neurol. Neurosci. 2015, 33, 895-910, DOI:10.3233/rnn-150572

IF: 2.661      A        Q3


Aranaz, I.; Acosta, N.; Férnandez-Valle, M.E.; Heras, A. Optimization of d-amino acid production catalyzed by immobilized multi-enzyme system in polyelectrolyte complex gel capsules.

J, Mol. Catal. B-Enzym.2015, 121, 45-52, DOI:10.1016/j.molcatb.2015.06.003

IF: 2.189      A        Q3


Aires-Trapote, A.; Hoyos, P.; Alcántara, A.R.; Tamayo, A.; Rubio, J.; Rumbero, A.; Hernaiz, M.J. Covalent Immobilization of Pseudomonas stutzeri Lipase on a Porous Polymer: An Efficient Biocatalyst for a Scalable Production of Enantiopure Benzoin Esters under Sustainable Conditions.

Org. Process Res. Dev 2015, 19, 687-694, DOI:10.1021/op500326k

IF: 2.992      A        Q1


Acosta, N.; Sanchez, E.; Calderon, L.; Cordoba-Diaz, M.; Cordoba-Diaz, D.; Dom, S.; Heras, A. Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres.

Marine Drugs 2015, 13, 5901-5919, DOI:10.3390/md13095901

IF: 3.345      A        Q1



Alonso-Fagúndez, N.; Laserna, V.; Alba-Rubio, A.C.; Mengibar, M.; Heras, A.; Mariscal, R.; Granados, M.L.

Poly-(styrene sulphonic acid): An acid catalyst from polystyrene waste for reactions of interest in biomass valorization.

Catal. Today 2014, 234, 285-294, DOI:10.1016/j.cattod.2014.01.041

IF: 3.893      A        Q1


Alcántara, A.R.; Pace, V.; Hoyos, P.; Sandoval, M.; Holzer, W.; Hernaiz, M.J.

Chemoenzymatic Synthesis of Carbohydrates as Antidiabetic and Anticancer Drugs.

Curr. Top. Med. Chem. 2014, 14, 2694-2711,

DOI: 10.2174/1568026614666141215151056

IF: 3.402      R        Q1


Garcia-Garcia, J.M.; Mar Bernal, M.; Verdejo, R.; Lopez-Manchado, M.A.; Doncel-Perez, E.; Garrido, L.; Quijada-Garrido, I.

Semiconductive Bionanocomposites of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) and MWCNTs for Neural Growth Applications.

J. Polym. Sci. Pt. B-Polym. Phys 2014, 52, 349-360, DOI:10.1002/polb.23417

IF: 3.830      A        Q1


Aranaz, I.; Martínez-Campos, E.; Nash, M.E.; Tardajos, M.G.; Reinecke, H.; Elvira, C.; Ramos, V.; López-Lacomba, J.L.; Gallardo, A. Pseudo-double network hydrogels with unique properties as supports for cell manipulation.

J. Mat. Chem. B, 2014, 2, 3839-3848, DOI:10.1039/c4tb00371c

IF: 4.726      A        Q1

Wagner, C.; Angeles Munoz, M.; Jareno, J.; Gutierrez Ortega, C.; Aguilar, A.; Carrillo Aranda, B.; Maldonado Sanz, J.A.; Civera, C.; Callol, L.

Volatile Organic Compounds, New Biomarkers in Exhaled Breath Samples of Lung Cancer Patients With and Without Chronic Obstructive Pulmonary Disease.

Chest 2014, 145, DOI:10.1378/chest.1824493

IF: 7.483      A        Q1


Jareno, J.; Angeles Munoz, M.; Wagner, C.; Civera, C.; Callol, L. Volatile Organic Compounds (VOC) in Exhaled Breath in Patients With Lung Cancer.

Chest 2014, 145, DOI:10.1378/chest.1821540

IF: 7.483      A        Q1



Pintado-Sierra, M.; Delgado, L.; Aranaz, I.; Marcos-Fernández, Á.; Reinecke, H.; Gallardo, A.; Zeugolis, D.; Elvira, C.

Surface hierarchical porosity in poly (ε-caprolactone) membranes with potential applications in tissue engineering prepared by foaming in supercritical carbon dioxide.

J. Supercrit. Fluids 2014, 95, 273-284, DOI:10.1016/j.supflu.2014.09.019

IF: 2.371      A        Q2


Aranaz, I.; Gutiérrez, M.C.; Ferrer, M.L.; Del Monte, F. Preparation of chitosan nanocompositeswith a macroporous structure by unidirectional freezing and subsequent freeze-drying.

Marine Drugs 2014, 12, 5619-5642, DOI:10.3390/md12115619

IF: 2.853      A        Q2


Civera, C.; Arias, C.; Elorza, M.A.; Elorza, B.; Garcia-Blanco, F.; Galera-Gomez, P.A. Hydrophobicity enhancement in micelles of Triton X-165 by the presence of the cosolvent 2,2,2 trifluoroethanol (TFE).

J. Mol. Liq. 2014, 199, 29-34, DOI:10.1016/j.molliq.2014.08.017

IF: 2.515      A        Q2


Bocourt, M.; Bada, N.; Acosta, N.; Bucio, E.; Peniche, C. Synthesis and characterization of novel pH-sensitive chitosan-poly(acrylamide-co-itaconic acid) hydrogels.

Polym. Int. 2014, 63, 1715-1723, DOI:10.1002/pi.4699

IF: 2.409      A        Q2


Aranaz, I.; Mengíbar, M.; Harris, R.; Miralles, B.; Acosta, N.; Calderón, L.; Sánchez, Á.; Heras, A. Role of physicochemical properties of chitin and chitosan on their functionality.

Current Chemical Biology 2014, 8, 27-42, 10.2174/221279680801141112095704

IF:      R        no ranked


Hoyos, P.; Pace, V.; Hernáiz, M.J.; Alcántara, A.R. Biocatalysis in the Pharmaceutical Industry. A greener future.

Curr. Green Chem. 2014, 1, 155-181, DOI:10.2174/2213346101666131113201722

IF:      R        no ranked


Alcántara, A.R.; Hernáiz, M.J.; Sánchez-Montero, J.M.; Saco, M.D.; Martín, M.S.; Torres, M.; Sanchez-Muñoz, A.; Guillén, C.; Heras, A.; Elorza, M. Biotecnología Farmacéutica, asignatura optativa de «obligado conocimiento» en el Grado de Farmacia (UCM). SEM@Foro, publicación semestral de la Sociedad Española de Microbiología (SEM) 2014.



IF:      A        no ranked




Tardajos, M.G.; Aranaz, I.; Pérez, M.; López, D.; Reinecke, H.; Elvira, C.; Gallardo, A.

Self-structuring in amphiphilic networks prepared by single conventional radical copolymerization of n -butyl methacrylate and vinylpyrrolidone.

Macromolecules 2013, 46, 5018-5025, DOI:10.1021/ma400483f

IF: 5.927      A        Q1


Bayon, C.; Cortes, A.; Aires-Trapote, A.; Civera, C.; Hernaiz, M.J.

Highly efficient and regioselective enzymatic synthesis of beta-(1 -> 3) galactosides in biosolvents.

RSC Advances 2013, 3, 12155-12163, DOI:10.1039/c3ra40860d

IF: 3.708      A        Q1


Quiñones, J.P.; Gothelf, K.V.; Kjems, J.; Yang, C.; Heras, A.; Schmidt, C.; Covas, C.P. Self-assembled nanoparticles of modified-chitosan conjugates for the sustained release of dl-α-tocopherol.

Carbohydr. Polym.2013, 92, 856-864, DOI:10.1016/j.carbpol.2012.10.005

IF: 3.198      A        Q1


Quiñones, J.P.; Gothelf, K.V.; Kjems, J.; Heras, A.; Schmidt, C.; Covas, C.P. N,O6-partially acetylated chitosan nanoparticles hydrophobically-modified for controlled release of steroids and vitamin E.

Carbohydr. Polym.2013, 91, 143-151, DOI:10.1016/j.carbpol.2012.07.080

IF: 3.916      A        Q1

Pace, V.; Castoldi, L.; Alcántara, A.R.; Holzer, W. Highly efficient and environmentally benign preparation of Weinreb amides in the biphasic system 2-MeTHF/water.

RSC Advances 2013, 3, 10158-10162, DOI:10.1039/c3ra41262h

IF: 3.708      A        Q1


Mengibar, M.; Mateos-Aparicio, I.; Miralles, B.; Heras, A. Influence of the physico-chemical characteristics of chito-oligosaccharides (COS) on antioxidant activity.

Carbohydr. Polym.2013, 97, 776-782, DOI:10.1016/j.carbpol.2013.05.035

IF: 3.916      A        Q1


Pace, V.; Hoyos, P.; Alcántara, A.R.; Holzer, W. Chemoselective CaO-Mediated Acylation of Alcohols and Amines in 2-Methyltetrahydrofuran.

ChemSusChem 2013, 6, 905-910, DOI:10.1002/cssc.201200922

IF: 6.913      A        Q1


Pace, V.; Holzer, W.; Verniest, G.; Alcántara, A.R.; De Kimpe, N. Chemoselective Synthesis of N-Substituted alpha-Amino-alpha '-chloro Ketones via Chloromethylation of Glycine-Derived Weinreb Amides.

Adv. Synth. Catal. 2013, 355, 919-926, DOI:10.1002/adsc.201201043

IF: 5.542      A        Q1


Sandoval, M.; Civera, C.; Berenguer, J.; Garcia-Blanco, F.; Hernaiz, M.J.

Optimised N-acetyl-D-lactosamine synthesis using Thermus thermophilus beta-galactosidase in bio-solvents.

Tetrahedron 2013, 69, 1148-1152, DOI:10.1016/j.tet.2012.11.053

IF: 2.517      A        Q2


Pace, V.; Castoldi, L.; Hernaiz, M.J.; Alcántara, A.R.; Holzer, W.

Chemoselective oxidative hydrolysis of EWG protected alpha-arylamino vinyl bromides to alpha-arylamino-alpha '-bromoacetones.

Tetrahedron Letters 2013, 54, 4369-4372, DOI:10.1016/j.tetlet.2013.05.118

IF: 2.397      A        Q2


Maraite, A.; Hoyos, P.; Daniel Carballeira, J.; Cabrera, A.C.; Ansorge-Schumacher, M.B.; Alcántara, A.R.

Lipase from Pseudomonas stutzeri: Purification, homology modelling and rational explanation of the substrate binding mode.

J. Mol. Catal. B-Enzym. 2013, 87, 88-98, DOI:10.1016/j.molcatb.2012.11.005

IF: 2.745      A        Q2


Hoyos, P.; Pace, V.; Alcántara, A.R. Biocatalyzed On Water Synthesis of Chiral Building Blocks for the Preparation of Anti-Cancer Drugs: a Greener Approach.

Curr. Org. Chem. 2013, 17, 1132-1157, DOI:10.2174/1385272811317110003

IF: 2.537      R        Q2


Fernandez-Lucas, J.; Harris, R.; Mata-Casar, I.; Heras, A.; de la Mata, I.; Arroyo, M.

Magnetic chitosan beads for covalent immobilization of nucleoside 2'-deoxyribosyltransferase: application in nucleoside analogues synthesis.

J. Ind. Microbiol. Biotechnol. 2013, 40, 955-966, DOI:10.1007/s10295-013-1304-4

IF: 2.505      A        Q2


Doncel-Perez, E.; Garcia-Alvarez, I.; Fernandez-Mayoralas, A.; Nieto-Sampedro, M.

Synthetic glycolipids for glioma growth inhibition developed from neurostatin and NF115 compound.

Bioorg. Med. Chem. Lett. 2013, 23, 435-439, DOI:10.1016/j.bmcl.2012.11.070

IF: 2.331      A        Q2


Calderón, L.; Harris, R.; Cordoba-Diaz, M.; Elorza, M.; Elorza, B.; Lenoir, J.; Adriaens, E.; Remon, J.P.; Heras, A.; Cordoba-Diaz, D.

Nano and microparticulate chitosan-based systems for antiviral topical delivery.

Eur. J. Pharm. Sci. 2013, 48, 216-222, DOI:10.1016/j.ejps.2012.11.002

IF: 3.005      A        Q2


Quiñones, J.P.; Gothelf, K.V.; Kjems, J.; Heras, A.; Schmidt, C.; Peniche, C.

Novel self-assembled nanoparticles of testosterone- modified glycol chitosan and fructose chitosan for controlled release.

J. Biomater. Tissue Eng. 2013, 3, 164-172, DOI:10.1166/jbt.2013.1071

IF: 1.167      A        Q4





Tardajos, M.G.; Aranaz, I.; Sayar, F.; Elvira, C.; Reinecke, H.; Piskin, E.; Gallardo, A.

Chemical guiding of magnetic nanoparticles in dispersed media containing poly-(methylmethacrylate-co-vinylpyrrolidone).

Langmuir 2012, 28, 5555-5561, DOI:10.1021/la204900c

IF: 4.187      A        Q1


Solano, D.M.; Hoyos, P.; Hernaiz, M.J.; Alcántara, A.R.; Sanchez-Montero, J.M.

Industrial biotransformations in the synthesis of building blocks leading to enantiopure drugs.

Bioresour. Technol. 2012, 115, 196-207, DOI:10.1016/j.biortech.2011.11.131

IF: 4.750      R        Q1

Quiñones, J.P.; Gothelf, K.V.; Kjems, J.; Heras, A.; Schmidt, C.; Covas, C.P.

Self-assembled nanoparticles of glycol chitosan - Ergocalciferol succinate conjugate, for controlled release.

Carbohydr. Polym.2012, 88, 1373-1377, DOI:10.1016/j.carbpol.2012.02.039

IF: 3.479      A        Q1


Pace, V.; Hoyos, P.; Castoldi, L.; Dominguez de Maria, P.; Alcántara, A.R.

2-Methyltetrahydrofuran (2-MeTHF): A Biomass-Derived Solvent with Broad Application in Organic Chemistry.

ChemSusChem 2012, 5, 1369-1379, DOI:10.1002/cssc.201100780

IF: 5.056      R        Q1


Pace, V.; Castoldi, L.; Alcántara, A.R.; Holzer, W.

Robust eco-friendly protocol for the preparation of gamma-hydroxy-alpha,beta-acetylenic esters by sequential one-pot elimination-addition of 2-bromoacrylates to aldehydes promoted by LTMP in 2-MeTHF.

Green Chem. 2012, 14, 1859-1863, DOI:10.1039/c2gc35305a

IF: 6.828      A        Q1


Okoli, C.; Sanchez-Dominguez, M.; Boutonnet, M.; Jaras, S.; Civera, C.; Solans, C.; Kuttuva, G.R.

Comparison and Functionalization Study of Microemulsion-Prepared Magnetic Iron Oxide Nanoparticles.

Langmuir 2012, 28, 8479-8485, DOI:10.1021/la300599q

IF: 4.187      A        Q1


Muneton-Gomez, V.C.; Doncel-Perez, E.; Fernandez, A.P.; Serrano, J.; Pozo-Rodrigalvarez, A.; Vellosillo-Huerta, L.; Taylor, J.S.; Cardona-Gomez, G.P.; Nieto-Sampedro, M.; Martinez-Murillo, R. Neural differentiation of transplanted neural stem cells in a rat model of striatal lacunar infarction: light and electron microscopic observations.

Front. Cell. Neurosci. 2012, 6, DOI:10.3389/fncel.2012.00030

IF: 4.469      A        Q1


Hoyos, P.; Pace, V.; Alcántara, A.R.

Dynamic Kinetic Resolution via Hydrolase-Metal Combo Catalysis in Stereoselective Synthesis of Bioactive Compounds.

Adv. Synth.Catal. 2012, 354, 2585-2611, DOI:10.1002/adsc.201200365

IF: 5.535      R        Q1


Sandoval, M.; Cortes, A.; Civera, C.; Trevino, J.; Ferreras, E.; Vaultier, M.; Berenguer, J.; Lozano, P.; Hernaiz, M.J.

Efficient and selective enzymatic synthesis of N-acetyl-lactosamine in ionic liquid: a rational explanation.

RSC Advances 2012, 2, 6306-6314, DOI:10.1039/c2ra20618h

IF: 2.562      A        Q2


Consuelo Muneton-Gomez, V.; Patricia Fernandez, A.; Serrano, J.; Vellosillo, L.; Herrero-Labrador, R.; Pozo-Rodrigalvarez, A.; Nieto-Sampedro, M.; Scot Taylor, J.; Doncel-Perez, E.; Martinez-Murillo, R. Experimental in vivo efficacy of stem cell therapy in a rat model of striatal lacunar infarction.

Brain Injury 2012, 26, 413-414, DOI: 10.13140/RG.2.1.2249.5122

IF: 1.513      A        Q2


Caterina Fragnelli, M.; Hoyos, P.; Romano, D.; Gandolfi, R.; Alcántara, A.R.; Molinari, F. Enantioselective reduction and deracemisation using the non-conventional yeast Pichia glucozyma in water/organic solvent biphasic systems: preparation of (S)-1,2-diaryl-2-hydroxyethanones (benzoins)

Tetrahedron 2012, 68, 523-528, DOI:10.1016/j.tet.2011.11.014

IF: 2.803      A        Q2