Liver injury and inflammation


Latest Publication from the lab

Intestinal Epithelial Cell-Derived Extracellular Vesicles Modulate Hepatic Injury via the Gut-Liver Axis During Acute Alcohol Injury

Work with us NOW

Our graduate training programs are designed for both scientist and clinicians. The School’s Ph.D. program in Biomedical Science Research recruits excellent students for intramural research groups. We also have positions for very motivated Postdoctoral Researchers via Regional Funding. Prospective students are welcome to apply by submitting a cover letter and a CV.


Contact us


Twitter: @CUBEROlab

How to find us

The Department of Immunology is located on the 4th Floor, Pavilion 5 within the School of Medicine at the Complutense University Madrid.

Google Maps and School of Medicine map

By Bus: G, U, 82, 132;

By Metro: Linea 6;





  • Prof. Matías Ávila, Director of the Hepatology Programme, CIMA, Pamplona, Spain
  • PD Dr. Lars P. Bechmann, Uniklinik Essen, Essen, Germany
  • Dr. Santiago Canals, Institute of Neurosciences, Alicante, Spain
  • Dr. Gang Zhao and Prof. Hai Hu, Oriental Affiliated Hospital with Tongji University, Shanghai, China
  • Profs. Maribel Lucena and Raul Andrade, Pharmacology Department, Malaga University School of Medicine, Malaga, Spain
  • Prof. Rafael Bañares and Javier Vaquero, Dept. Gastroenterology and Hepatology, University Hospital Gregorio Marañon, Madrid, Spain
  • Drs. Aldo Torres y Ricardo U. Macias-Rodriguez, Department of Gastroenterology, National Institute of Medical Sciences and Nutrition "Salvador Zubirán", Mexico D.F, Mexico
  • Dr. Leonard J. Nelson, Institute for Bioengineering, School of Engineering, The University of Edinburgh, Edinburgh, Scotland 
  • Prof. Lang Tran, IOM, Edinburgh, Scotland

Our Research

  • Mitogen activated protein kinases (MAPKs)
  • Reactive Oxygen (ROS) and Nitrogen Species (RNS)
  • Non-alcoholic steatohepatitis(NASH)
  • Drug-induced liver injury (DILI)
  • Alcoholic liver disease (ALD)
  • Chronic liver disease (CLD)
  • Hepatocellular carcinoma (HCC)
  • Gallbladder disorders


  • Hepatocyte Jnk1 and Jnk2 exert combined effects in protecting against toxic liver injury.
  • Jnk1 in bone marrow derived cells mediates liver regeneration.
  • Hematopoietic cells-derived Jnk1 triggers chronic inflammation and end-stage carcinogenesis
  • Jnk1 in hepatic stellate cells is a crucial mediator of hepatic inflammation.


Raquel Benedé Ubieto, Ph.D.

Olga Estévez Vázquez, Ph.D.

Alejandro Hionides, Ph.D. student

Hanghang Wu, Ph.D. student

Hector Leal Lasalle, Ph.D. student

Lucia Pérez de Ayala, Project Management