GRUPO MANUEL GUZMÁN (NEUROPROTECCIÓN)

JEFE DE GRUPO (NEUROPROTECCIÓN): MANUEL GUZMÁN

Neuronal Cannabinoid CB1 Receptors Suppress the Growth of Melanoma Brain Metastases by Inhibiting Glutamatergic Signalling

Costas-Insua, C.*, Seijo-Vila, M.*, Blázquez, C., Blasco-Benito, S., Rodríguez-Baena, J.R., Marsicano, G., Pérez-Gómez, E., Sánchez, C., Sánchez-Laorden, B., Guzmán, M.

Cancers 2023

Control of a hippocampal recurrent excitatory circuit by cannabinoid receptor-interacting protein Gap43

Maroto, I.B., Costas-Insua, C., Berthoux, C., Moreno, E., Ruiz-Calvo, A., Montero-Fernández, C., Macías-Camero, A., Martín, R., García-Font, N., Sánchez-Prieto, J., Marsicano, G., Bellocchio, L., Canela, E.I., Casadó, V., Galve-Roperh, I., Núñez, A., Fernández de Sevilla, D., Rodríguez-Crespo, I., Castillo, P.B., Guzmán, M.

Nature Communications 2023

Endocannabinoid signaling in glioma

Costas-Insua, C., Guzmán, M.

Glia 2022

Identification of BiP as a CB₁ receptor-interacting protein that fine-tunes cannabinoid signaling in the mouse brain

Costas-Insua, C., Moreno, E., Maroto, I.B., Ruiz-Calvo, A., Bajo-Grañeras, R., Martín-Gutiérrez, D., Diez-Alarcia, R., Vilaró, M.T., Cortés, R., García-Font, N., Martín, R., Espina, M., Botta, J., Ginés, S., McCormick, P.J., Sánchez-Prieto, J., Galve-Roperh, I., Mengod, G., Urigüen, L., Marsicano, G., Bellocchio, L., Canela, E.I., Casadó, V., Rodríguez-Crespo, I., Guzmán, M.

Journal of Neuroscience 2021

Cannabinoid-induced motor dysfunction via autophagy inhibition

Blázquez, C., Ruiz-Calvo, A., Bajo-Grañeras, R., Baufreton, J.M., Resel, E., Varilh, M., Pagano Zottola, A.C., Mariani, Y., Cannich, A., Rodríguez-Navarro, J.A., Marsicano, G., Galve-Roperh, I., Bellocchio, L. & Guzmán, M.

Autophagy 2020

Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB₁ receptors

Paraíso-Luna, J., Aguareles, J., Martín, R., Ayo-Martín, A.C., Simón-Sánchez, S., García-Rincón, D., Costas-Insua, C., García-Taboada, E., de Salas-Quiroga, A., Díaz-Alonso, J., Liste, I., Sánchez-Prieto, J., Cappello, S., Guzmán, M. & Galve-Roperh, I.

Development 2020

Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling

Bartoll, A., Toledano-Zaragoza, A., Casas, J., Guzmán, M., Schuchman, E.H. & Ledesma, M.D.

EMBO Molecular Medicine 2020

Δ⁹-Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo

Huerga-Gómez, A., Aguado, T. Sánchez-de la Torre, A., Bernal-Chico, A. Matute, C. Mato, S., Guzmán, M., Galve-Roperh, I. & Palazuelos, J.

Glia 2020

Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination

eLife 2020

Possible therapeutic applications of cannabis in the neuropsychopharmacology field

Fernández-Ruiz, J., Galve-Roperh, I., Sagredo, O. y Guzmán, M.

European Neuropsychopharmacology 2020

Glucose metabolism links astroglial mitochondria to cannabinoid effects

Jimenez-Blasco, D., Busquets-Garcia, A., Hebert-Chatelain, E., Serrat, R., Vicente-Gutierrez, C., Ioannidou, C., Gómez-Sotres, P., Lopez-Fabuel, I., Resch-Beusher, M., Resel, E., Arnouil, D., Saraswat, D., Varilh, M., Cannich, A., Julio-Kalajzic, F., Bonilla-Del Río, I., Almeida, A., Puente, N., Achicallende, S., Lopez-Rodriguez, M.L., Jollé, C., Déglon, N., Pellerin, L., Josephine, C., Bonvento, G., Panatier, A., Lutz, B., Piazza, P.V., Guzmán, M., Bellocchio, L., Bouzier-Sore, A.K., Grandes, P., Bolaños, J.P., Marsicano, G.

Nature 2020

Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington’s disease

Moreno-Delgado, D., Puigdellívol, M., Moreno, E., Rodríguez-Ruiz, M., Botta, J., Gasperini, P., Chiarlone, A., Howell, L.A., Scarselli, M., Casadó, V., Cortés, A., Ferré, S., Guzmán, M., Lluís, C., Alberch, J., Canela, E.I., Ginés, S., McCormick, P.J.

eLife 2020

Long-term hippocampal interneuronopathy drives sex-dimorphic spatial memory impairment induced by prenatal THC exposure

de Salas-Quiroga, A., García-Rincón, D., Gómez-Domínguez, D., Valero, M., Simón-Sánchez, S., Paraíso-Luna, J., Aguareles, J., Pujadas, M., Muguruza, C., Callado, L., Lutz, B., Guzmán, M., Menéndez de la Prida, L. & Galve-Roperh, I.

Neuropsychopharmacology 2020

Can cannabis cure cancer?

Abrams, D.I. & Guzmán, M.

JAMA Oncology 2020

Astroglial monoacylglycerol lipase controls mutant huntingtin-induced damage of striatal neurons

Ruiz-Calvo, A., Bajo-Grañeras, R., Maroto, I.B., Zian, D., Grabner, G.F., García-Taboada, E., Resel, E., Zechner, R., Zimmermann, R., Ortega-Gutiérrez, S., Galve-Roperh, I., Bellocchio, L., Guzmán, M.

Neuropharmacology 2019

Pathway-specific control of striatal neuron vulnerability by corticostriatal cannabinoid CB₁ receptors

Ruiz-Calvo, A., Maroto, I.B., Bajo-Grañeras, R., Chiarlone, A., Gaudioso, A., Ferrero, J.J., Resel, E., Sánchez-Prieto, J., Rodríguez-Navarro, J.A., Marsicano, G., Galve-Roperh, I., Bellocchio, L., Guzmán, M.

Cerebral Cortex 2018

Singular location and signaling profile of adenosine A_2A-cannabinoid CB₁ receptor heteromers in the dorsal striatum

Moreno, E., Chiarlone, A., Medrano, M., Puigdellívol, M., Bibic, L., Howell, L.A., Resel, E., Puente, N., Casarejos, M.J., Perucho, J., Botta, J., Suelves, N., Ciruela, F., Ginés, S., Galve-Roperh, I., Casadó, V., Grandes, P., Lutz, B., Monory, K., Canela, E.I., Lluís, C., McCormick, P.J., Guzmán, M.

Neuropsychopharmacology 2018

Endocannabinoid actions on cortical terminals orchestrate local modulation of dopamine release in the nucleus accumbens

Mateo, Y., Johnson, K.A., Covey, D.P., Atwood, B.K., Wang, H.L., Zhang, S., Gildish, I., Cachope, R., Bellocchio, L., Guzmán, M., Morales, M., Cheer, J.F., Lovinger, D.M.

Neuron 2017

Cannabinoid type-2 receptor drives neurogenesis and improves functional outcome after stroke

Bravo-Ferrer, I., Cuartero, M.I., Zarruk, J.G., Pradillo, J.M., Hurtado, O., Romera, V.G., Díaz-Alonso, J., García-Segura, J.M., Guzmán, M., Lizasoain, I., Galve-Roperh, I., Moro, M.A.

Stroke 2017

Loss of cannabinoid CB₁ receptors induces cortical migration malformations and increases seizure susceptibility

Díaz-Alonso, J., de Salas-Quiroga, A., Paraíso-Luna, J., García-Rincón, D., Garcez, P.P., Parsons, M., Andradas, C., Sánchez, C., Guillemot, F., Guzmán, M., Galve-Roperh, I.

Cerebral Cortex 2017

Anticancer mechanisms of cannabinoids

Velasco, G., Sánchez, C., Guzmán, M.

Current Oncology 2016

Sustained Gq protein signaling induces striatal neurotoxicity via a PLC/Ca2+/PYK2/JNK pathway

Bellocchio, L., Ruiz-Calvo, A., Chiarlone, A., Cabanas, M., Resel, E., Cazalets, J.R., Blázquez, C., Cho, Y.H., Galve-Roperh, I., Guzmán, M.

Journal of Neuroscience 2016

Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer

Andradas, C., Blasco-Benito, S., Castillo-Lluva, S., Dillenburg-Pilla, P., Diez-Alarcia, R., Juanes-García, A., García-Taboada, E., Hernando-Llorente, R., Soriano, J., Hamann, S., Wenners, A., Alkatout, I., Klapper, W., Rocken, C., Bauer, M., Arnold, N., Quintanilla, M., Megías, D., Vicente-Manzanares, M., Urigüen, L., Gutkind, J.S., Guzmán, M., Pérez-Gómez, E., Sánchez, C.

Oncotarget 2016

A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington’s disease

García-Caldentey, J., Trigo-Cubillo, P., Ruiz-Romero, C., García-Ribas, G., Alonso-Arias, M.A., García de Yébenes, M.J., Tolón, R.M., Galve-Roperh, I., Sagredo, O., Valdeolivas, S., Resel, E., Ortega-Gutiérrez, S., García-Bermejo, M.L., Fernández-Ruiz, J., Guzmán, M., García de Yébenes, J., López-Sendón, J.L.

Journal of Neurology 2016

MicroRNA let-7d is a target of cannabinoid CB₁ receptor and controls cannabinoid signaling

Chiarlone, A., Börner, C., Martín-Gómez, L., Jiménez-González, A., García-Concejo, A., García-Bermejo, M.L., Lorente, M., Blázquez, C., García-Taboada, E., de Haro, A., Martella, E., Höllt, V., Rodríguez, R., Galve-Roperh, I., Kraus, J., Guzmán, M.

Neuropharmacology 2016

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autophago-lysosome destabilization

Hernández-Tiedra, S., Fabriàs, G., Dávila, D., Salanueva, I.J., Casas, J., Montes, L.R., Antón, Z., García-Taboada, E., Salazar-Roa, M., Lorente, M., Nylandsted, J., Armstrong, J., López-Valero, I., McKee, C.S., Serrano-Puebla, A., García-López, R., González-Martínez, J., Abad, J.L., Hanada, K., Boya, P., Goñi, F.M., Guzmán, M., Lovat, P., Jäättelä, M., Alonso, A., Velasco, G.

Autophagy 2016

Cannabis in cancer care

Abrams, D.I., Guzmán, M.

Clinical Pharmacology & Therapeutics 2015

Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB₁ receptors on developing cortical neurons

De Salas-Quiroga, A., Díaz-Alonso, J., García-Rincón, D., Remmers, F., Vega, D., Gómez-Cañas, M., Lutz, B., Guzmán, M., Galve-Roperh, I.

Proceedings of the National Academy of Sciences of the United States of America 2015

Cannabinoid receptor CB₂ drives HER2 pro-oncogenic signaling in breast cancer

Pérez-Gómez, E., Andradas, C., Caffarel, M.M., Blasco-Benito, S., García-Taboada, E., Villa-Morales, M., Moreno, E., Hamann, S., Martín-Villar, E., Flores, J.M., Wenners, A., Alkatout, I., Klapper, W., Röcken, C., Bronsert, P., Stickeler, E., Staebler, A., Bauer, M., Arnold, N., Soriano, J., Pérez-Martínez, M., Megías, D., Moreno-Bueno, G., Ortega-Gutiérrez, S., Artola, M., Vázquez-Villa, H., Quintanilla, M., Fernández-Piqueras, J., Canela, E.I., McCormick, P.J:, Guzmán, M., Sánchez, C.

Journal of the National Cancer Institute 2015

The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway

Blázquez, C., Chiarlone, A., Bellocchio, L., Resel, E., Pruunsild, P., García-Rincón, D., Sendtner, M., Timmusk, T., Lutz, B., Galve-Roperh, I., Guzmán, M.

Cell Death & Differentiation 2015

Early social enrichment rescues adult brain and behavioral abnormalities in a mouse model of fragile X syndrome

Oddi, D., Subashi, E., Middei, S., Bellocchio, L., Lemaire-Mayo, V., Guzmán, M., Crusio, W.E., D’Amato, F., Pietropaolo, S.

Neuropsychopharmacology 2015

Chronic cannabinoid receptor stimulation selectively prevents motor impairments in a mouse model of Huntington’s disease

Pietropaolo, S., Bellocchio, L., Ruiz-Calvo, A., Cabanas, M., Du, Z., Guzmán, M., Garret, M., Cho, Y.H.

Neuropharmacology 2015

Loss of tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation

Salazar, M., Lorente, M., García-Taboada, M., Pérez Gómez, E., Dávila, D., Zúñiga-García, P., Flores, J.M., Rodríguez, A., Hegedus, Z., Mosén-Ansorena, D., Aransay, A.M., Hernández-Tiedra, S., López-Valero, I., Quintanilla, M., Sánchez, C., Iovanna, J.L., Dusetti, N., Guzmán, M., Francis, S.E., Carracedo, A., Kiss-Toth, E., Velasco, G.

Cell Death & Differentiation 2015

CB₁ cannabinoid receptor-dependent activation of mTORC1/Pax6 signaling drives Tbr2 expression and basal progenitor expansion in the developing mouse cortex

Díaz-Alonso, J., Aguado, T., de Salas-Quiroga, A., Ortega, Z., Guzmán, M. & Galve-Roperh, I.

Cerebral Cortex 2015

Programming of neural cells by (endo-)cannabinoids: from physiological rules to emerging therapies

Maccarrone, M., Guzmán, M., Mackie, K., Doherty, P. & Harkany, T.

Nature Reviews Neuroscience 2014

Targeting CB₂-GPR55 receptor heteromers modulates cancer cell signaling

Moreno, E., Andradas, C., Medrano, M., Caffarel, M.M., Pérez-Gómez, E., Blasco-Benito, S., Gómez-Cañas, M., Pazos, M.R., Irving, A.J., Lluís, C., Canela, E.I., Fernández-Ruiz, J., Guzmán, M., McCormick, P.J., Sánchez, C.

Journal of Biological Chemistry 2014

A restricted population of CB₁ cannabinoid receptors with neuroprotective activity

Chiarlone, A., Bellocchio, L., Blázquez, C., Resel, E., Soria-Gómez, E., Cannich, A., Ferrero, J.J., Sagredo, O., Benito, C., Romero, J., Sánchez-Prieto, J., Lutz, B., Fernández-Ruiz, J., Galve-Roperh, I. & Guzmán, M.

Proceedings of the National Academy of Sciences of the United States of America 2014

The endocannabinoid system controls food intake via olfactory processes

Soria-Gómez, E., Bellocchio, L., Reguero, L., Lepouse, G., Martin, C., Bendahmane, M., Ruehle, S., Remmers, F., Desprèz, T., Matias, I., Wiesner, T., Cannich, A., Wadleigh, A., Pape, H.P., Chiarlone, A.P., Quarta, C., Verrier, D., Vincent, P., Massa, F., Lutz, B., Guzmán, M., Gurden, H., Ferreira, G., Lledo, P.M., Grandes, P., Marsicano, G.

Nature Neuroscience 2014

Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation

Galve-Roperh, I., Chiurchiù, V., Díaz-Alonso, J., Bari, M., Guzmán, M., Maccarrone, M.

Progress in Lipid Research 2013

The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action

Salazar, M., Lorente, M., García-Taboada, E., Hernández-Tiedra, S., Dávila, D., Francis, S.E., Guzmán, M., Kiss-Toth, E., Velasco, G.

Biochimica et Biophysica Acta 2013

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

Campos, A.C., Ortega, Z., Palazuelos, J., Fogaça, M.V., Aguiar, D.C., Díaz-Alonso, J., Ortega-Gutiérrez, S., Henar, S., Moreira F.A., Guzmán, M., Galve-Roperh, I., Guimarães, F.S.

International Journal of Neuropsychopharmacology 2013

Activation of the sympathetic nervous system mediates hypophagic and anxiety-related effects of CB₁ receptor blockade

Bellocchio, L., Soria-Gomez, E., Quarta, C., Metna-Laurent, M., Cardinal, P., Binder, E., Cannich, A., Delamarre, A., Häring, M., Martín-Fontecha, M., Vega, D., Bartsch, D., Monory, K., Lutz, B., Chaouloff, F., Pagotto, U., Guzmán, M., Cota, D., Marsicano, G.

Proceedings of the National Academy of Sciences of the United States of America 2013

Natural cannabinoids improve dopamine neurotransmission and tau and amyloid pathology in a mouse model of tauopathy

Casarejos, M.J., Perucho. J., Gómez, A., Muñoz, M.P., Fernández-Estévez, M., Sagredo, O., Fernández Ruiz, J., Guzmán, M., García de Yébenes, J., Mena, M.A.

Journal of Alzheimer’s Disease 2013

The orphan receptor GPR55 promotes skin carcinogenesis in mice and is upregulated in human squamous cell carcinomas

Pérez-Gómez, E., Andradas, C., Flores, J.M., Quintanilla, M., Paramio, J.M., Guzmán, M., Sánchez, C.

Oncogene 2013

Endocannabinoids via CB₁ receptors act as neurogenic niche cues during cortical development

Díaz-Alonso, J., Guzmán, M., Galve-Roperh, I.

Philosophical Transactions of the Royal Society 2012

Cannabinoids: a new hope for breast cancer therapy?

Caffarel, M.M., Andradas, C., Pérez-Gómez, E., Guzmán, M., Sánchez, C.

Cancer Treatment Reviews 2012

Towards the use of cannabinoids as antitumour agents

Velasco, G., Sánchez, C. & Guzmán, M.