PUBLICATIONS

2022
- Dissemination Routes of Carbapenem and Pan-Aminoglycoside Resistance Mechanisms in Hospital and Urban Wastewater Canalizations of Ghana. Delgado-Blas JF, Valenzuela Agüi C, Marin Rodriguez E, Serna C, Montero N, Saba CKS, Gonzalez-Zorn B. mSystems. 2022 Feb 22;7(1):e0101921. doi: 10.1128/msystems.01019-21. Epub 2022 Feb 1. 
2021
- Evolution of ColE1-like plasmids across γ-Proteobacteria: From bacteriocin production to antimicrobial resistance. Ares-Arroyo M, Rocha EPC, Gonzalez-Zorn B.  PLoS Genet. 2021 Nov 30;17(11):e1009919. doi: 10.1371/journal.pgen.1009919. 
Conjugation Inhibitors Effectively Prevent Plasmid Transmission in Natural Environments. Palencia-Gándara C, Getino M, Moyano G, Redondo S, Fernández-López R, González-Zorn B, de la Cruz F. mBio. 2021 Aug 31;12(4):e0127721. doi: 10.1128/mBio.01277-21. Epub 2021 Aug 24. 
- Genomic evolution of antimicrobial resistance in Escherichia coli. Leekitcharoenphon P, Johansson MHK, Munk P, Malorny B, Skarżyńska M, Wadepohl K, Moyano G, Hesp A, Veldman KT, Bossers A; EFFORT Consortium, Zając M, Wasyl D, Sanders P, Gonzalez-Zorn B, Brouwer MSM, Wagenaar JA, Heederik DJJ, Mevius D, Aarestrup FM. Sci Rep. 2021 Jul 23;11(1):15108. doi: 10.1038/s41598-021-93970-7. 
- Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments. Delgado-Blas JF, Ovejero CM, David S, Montero N, Calero-Caceres W, Garcillan-Barcia MP, de la Cruz F, Muniesa M, Aanensen DM, Gonzalez-Zorn B.  Commun Biol. 2021 Apr 12;4(1):457. doi: 10.1038/s42003-021-01949-x. 
- Antibiotic use in the COVID-19 crisis in Spain. Gonzalez-Zorn B. Clin Microbiol Infect. 2021 Apr;27(4):646-647. doi: 10.1016/j.cmi.2020.09.055. Epub 2020 Nov 25. 
2020

Resistance to colistin and production of extended-spectrum β-lactamases and/or AmpC enzymes in Salmonella isolates collected from healthy pigs in Northwest Spain in two periods: 2008-2009 and 2018. Sevilla E, Vico JP, Delgado-Blas JF, González-Zorn B, Marín CM, Uruén C, Martín-Burriel I, Bolea R, Mainar-Jaime RC.  Int J Food Microbiol. 2021 Jan 2;338:108967. doi: 10.1016/j.ijfoodmicro.2020.108967. Epub 2020 Nov 10. 

Extensive antimicrobial resistance mobilization via multicopy plasmid encapsidation mediated by temperate phages. Lorena Rodríguez-Rubio, Carlos Serna, Manuel Ares-Arroyo, Bosco R Matamoros, Jose F Delgado-Blas, Natalia Montero, Cristina Bernabe-Balas, Emilia F Wedel, Irene S Mendez, Maite Muniesa, Bruno Gonzalez-Zorn. J Antimicrob Chemother . 2020 Jul 28;dkaa311. doi: 10.1093/jac/dkaa311.

Antibiotic resistance patterns in human, animal, food and environmental isolates in Ghana: a review. Pilar Garcia-Vello, Bruno Gonzalez-Zorn, Courage Kosi Setsoafia Saba. Pan Afr Med J . 2020 Feb 12;35:37. doi: 10.11604/pamj.2020.35.37.18323. eCollection 2020.

- A cross-sectional study on antibiotic prescription in a teaching hospital in Ghana. Pilar Garcia-Vello, Fareeda Brobbey, Bruno Gonzalez-Zorn, Courage Kosi Setsoafia Saba. Pan Afr Med J . 2020 Jan 15;35:12. doi: 10.11604/pamj.2020.35.12.18324. eCollection 2020.

- Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration. Zivanovic J, Kouroussis E, Kohl JB, Adhikari B, Bursac B, Schott-Roux S, Petrovic D, Miljkovic JL, Thomas-Lopez D, Jung Y, Miler M, Mitchell S, Milosevic V, Gomes JE, Benhar M, Gonzalez-Zorn B, Ivanovic-Burmazovic I, Torregrossa R, Mitchell JR, Whiteman M, Schwarz G, Snyder SH, Paul BD, Carroll KS, Filipovic MR. Cell Metab. 2020 Jan 7;31(1):207. doi: 10.1016/j.cmet.2019.12.001.

- Wild griffon vultures (Gyps fulvus) fed at supplementary feeding stations: Potential carriers of pig pathogens and pig-derived antimicrobial resistance?. Sevilla E, Marín C, Delgado-Blas JF, González-Zorn B, Vega S, Kuijper E, Bolea R, Mainar-Jaime RC. Transbound Emerg Dis. 2020 Jan 4. doi: 10.1111/tbed.13470.

Econometric ARIMA methodology to elucidate the evolution of trends in nosocomial antimicrobial resistance rates in the European Union. Ortega-Huedo R, Cuesta M, Hoefer A, Gonzalez-Zorn B. Int J Antimicrob Agents. 2020 Jan;55(1):105800. doi: 10.1016/j.ijantimicag.2019.09.004. Epub 2019 Sep 12.

2019

Successful Host Adaptation of IncK2 Plasmids. Rozwandowicz M, Brouwer MSM, Mughini-Gras L, Wagenaar JA, Gonzalez-Zorn B, Mevius DJ, Hordijk J. Front Microbiol. 2019 Oct 15;10:2384. doi: 10.3389/fmicb.2019.02384. eCollection 2019.

Prevalence of Beta-Lactam and Quinolone/Fluoroquinolone Resistance in Enterobacteriaceae From Dogs in France and Spain-Characterization of ESBL/pAmpC Isolates, Genes, and Conjugative Plasmids. Dupouy V, Abdelli M, Moyano G, Arpaillange N, Bibbal D, Cadiergues MC, Lopez-Pulin D, Sayah-Jeanne S, de Gunzburg J, Saint-Lu N, Gonzalez-Zorn B, Andremont A, Bousquet-Mélou A. Front Vet Sci. 2019 Aug 30;6:279. doi: 10.3389/fvets.2019.00279. eCollection 2019.

- Prevalence of Beta-Lactam and Quinolone/Fluoroquinolone Resistance in Enterobacteriaceae From Dogs in France and Spain-Characterization of ESBL/pAmpC Isolates, Genes, and Conjugative PlasmidsDupouy V, Abdelli M, Moyano G, Arpaillange N, Bibbal D, Cadiergues MC, Lopez-Pulin D, Sayah-Jeanne S, de Gunzburg J, Saint-Lu N, Gonzalez-Zorn B, Andremont A, Bousquet-Mélou A. Front Vet Sci. 2019 Aug 30;6:279. doi: 10.3389/fvets.2019.00279. eCollection 2019. PubMed PMID: 31544108; PubMed Central PMCID: PMC6730528.

- The bla (NDM-1)-Carrying IncA/C(2)  Plasmid Underlies Structural Alterations and Cointegrate Formation In VivoHadziabdic S, Fischer J, Borowiak M, Malorny B, Juraschek K, Kaesbohrer A, Guerra B, Deneke C, Gonzalez-Zorn B, Szabo I.  Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e00380-19. doi: 10.1128/AAC.00380-19. Print 2019 Aug. PubMed PMID: 31109975; PubMed Central PMCID: PMC6658791.

2018

Educating in antimicrobial resistance awareness: adaptation of the Small World Initiative program to service-learningValderrama MJ, González-Zorn B, de Pablo PC, Díez-Orejas R, Fernández-Acero T, Gil-Serna J, de Juan L, Martín H, Molina M, Navarro-García F, Patiño B, Pla J, Prieto D, Rodríguez C, Román E, Sanz-Santamaría AB, de Silóniz MI, Suárez M, Vázquez C, Cid VJ. FEMS Microbiol Lett. 2018 Sep 1;365(17). doi: 10.1093/femsle/fny161. PubMed PMID: 29982335.

- Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii in the Intensive Care Unit of Uruguay's University Hospital Identifies the First rmtC Gene in the SpeciesBado I, Papa-Ezdra R, Delgado-Blas JF, Gaudio M, Gutiérrez C, Cordeiro NF, García-Fulgueiras V, Araújo Pirez L, Seija V, Medina JC, Rieppi G, Gonzalez-Zorn B, Vignoli R. Microb Drug Resist. 2018 Sep;24(7):1012-1019. doi: 10.1089/mdr.2017.0300. Epub 2018 Jun 19. PubMed PMID: 29920143; PubMed Central PMCID: PMC6154759.

- Abundance and diversity of the faecal resistome in slaughter pigs and broilers in nine European countries. Munk P, Knudsen BE, Lukjancenko O, Duarte ASR, Van Gompel L, Luiken REC, Smit LAM, Schmitt H, Garcia AD, Hansen RB, Petersen TN, Bossers A, Ruppé E; EFFORT Group, Lund O, Hald T, Pamp SJ, Vigre H, Heederik D, Wagenaar JA, Mevius D, Aarestrup FM. Nat Microbiol. 2018 Aug;3(8):898-908. doi: 10.1038/s41564-018-0192-9. Epub 2018 Jul 23.

Prevalence and Molecular Characterization of New Delhi Metallo-Beta-Lactamases in Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii from India. Rahman M, Prasad KN, Gupta S, Singh S, Singh A, Pathak A, Gupta KK, Ahmad S, Gonzalez-Zorn B.  Microb Drug Resist. 2018 Jul/Aug;24(6):792-798. doi: 10.1089/mdr.2017.0078. Epub 2017 Oct 23. PubMed PMID: 29058515.

Plasmids carrying antimicrobial resistance genes in EnterobacteriaceaeRozwandowicz M, Brouwer MSM, Fischer J, Wagenaar JA, Gonzalez-Zorn B, Guerra B, Mevius DJ, Hordijk J. J Antimicrob Chemother. 2018 May 1;73(5):1121-1137. doi: 10.1093/jac/dkx488. Review. PubMed PMID: 29370371.

In Vivo Transfer and Microevolution of Avian Native IncA/C(2)bla(NDM-1)-Carrying Plasmid pRH-1238 during a Broiler Chicken Infection Study.  Hadziabdic S, Fischer J, Malorny B, Borowiak M, Guerra B, Kaesbohrer A, Gonzalez-Zorn B, Szabo I. Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02128-17. doi: 10.1128/AAC.02128-17. Print 2018 Apr. PubMed PMID: 29437622; PubMed Central PMCID: PMC5913973.

 PCR-Based Analysis of ColE1 Plasmids in Clinical Isolates and Metagenomic Samples Reveals Their Importance as Gene Capture Platforms.Ares-Arroyo M, Bernabe-Balas C, Santos-Lopez A, Baquero MR, Prasad KN, Cid D, Martin-Espada C, San Millan A, Gonzalez-Zorn B. Front Microbiol. 2018 Mar 16;9:469. doi: 10.3389/fmicb.2018.00469. eCollection 2018. PubMed PMID: 29615998; PubMed Central PMCID: PMC5864857.

Emergence of Chromosome-Borne Colistin Resistance Gene mcr-1 in Clinical Isolates of Klebsiella pneumoniae from IndiaSingh S, Pathak A, Kumar A, Rahman M, Singh A, Gonzalez-Zorn B, Prasad KN. Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01885-17. doi: 10.1128/AAC.01885-17. Print 2018 Feb. PubMed PMID: 29133565; PubMed Central PMCID: PMC5786762.

In-depth resistome analysis by targeted metagenomics. Lanza VF, Baquero F, Martínez JL, Ramos-Ruíz R, González-Zorn B, Andremont A, Sánchez-Valenzuela A, Ehrlich SD, Kennedy S, Ruppé E, van Schaik W, Willems RJ, de la Cruz F, Coque TM. Microbiome. 2018 Jan 15;6(1):11. doi: 10.1186/s40168-017-0387-y. PubMed PMID: 29335005; PubMed Central PMCID: PMC5769438.

2017

- A novel mutation in pmrB mediates colistin resistance during therapy of Acinetobacter baumanniiDahdouh E, Gómez-Gil R, Sanz S, González-Zorn B, Daoud Z, Mingorance J, Suárez M. Int J Antimicrob Agents. 2017 Jun;49(6):727-733. doi: 10.1016/j.ijantimicag.2017.01.031. Epub 2017 Apr 21. PubMed PMID: 28438568.

Highly Tigecycline-Resistant Klebsiella pneumoniae Sequence Type 11 (ST11) and ST147 Isolates from Companion Animals.  Ovejero CM, Escudero JA, Thomas-Lopez D, Hoefer A, Moyano G, Montero N, Martin-Espada C, Gonzalez-Zorn B. Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02640-16. doi: 10.1128/AAC.02640-16. Print 2017 Jun. PubMed PMID: 28396550; PubMed Central PMCID: PMC5444156.

Spread of mcr-1-carrying Enterobacteriaceae in sewage water from Spain. Ovejero CM, Delgado-Blas JF, Calero-Caceres W, Muniesa M, Gonzalez-Zorn B. J Antimicrob Chemother. 2017 Apr 1;72(4):1050-1053. doi: 10.1093/jac/dkw533. PubMed PMID: 28073965; PubMed Central PMCID: PMC5890673.

 A Naturally Occurring Single Nucleotide Polymorphism in a Multicopy Plasmid Produces a Reversible Increase in Antibiotic ResistanceSantos-Lopez A, Bernabe-Balas C, Ares-Arroyo M, Ortega-Huedo R, Hoefer A, San Millan A, Gonzalez-Zorn B. Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e01735-16. doi: 10.1128/AAC.01735-16. Print 2017 Feb. PubMed PMID: 27895020; PubMed Central PMCID: PMC5278757.

2016

 Coexistence of mcr-1 and blaNDM-1 in Escherichia coli from Venezuela. Delgado-Blas JF, Ovejero CM, Abadia-Patiño L, Gonzalez-Zorn B. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6356-8. doi: 10.1128/AAC.01319-16. Print 2016 Oct. PubMed PMID: 27431212; PubMed Central PMCID: PMC5038285.

2015

 RmtC and RmtF 16S rRNA Methyltransferase in NDM-1-Producing Pseudomonas aeruginosaRahman M, Prasad KN, Pathak A, Pati BK, Singh A, Ovejero CM, Ahmad S, Gonzalez-Zorn B. Emerg Infect Dis. 2015 Nov;21(11):2059-62. doi: 10.3201/eid2111.150271. PubMed PMID: 26488937; PubMed Central PMCID: PMC4622239.

Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniaeCannatelli A, Santos-Lopez A, Giani T, Gonzalez-Zorn B, Rossolini GM. Antimicrob Agents Chemother. 2015 May;59(5):2898-900. doi: 10.1128/AAC.04998-14. Epub 2015 Feb 17. PubMed PMID: 25691629; PubMed Central PMCID: PMC4394794.

Novel blaROB-1-bearing plasmid conferring resistance to β-lactams in Haemophilus parasuis isolates from healthy weaning pigs.  Moleres J, Santos-López A, Lázaro I, Labairu J, Prat C, Ardanuy C, González-Zorn B, Aragon V, Garmendia J. Appl Environ Microbiol. 2015 May 1;81(9):3255-67. doi: 10.1128/AEM.03865-14. Epub 2015 Mar 6. PubMed PMID: 25747001; PubMed Central PMCID: PMC4393459.

Culturable aerobic and facultative bacteria from the gut of the polyphagic dung beetle Thorectes lusitanicus Hernández N, Escudero JA, San Millán Á, González-Zorn B, Lobo JM, Verdú JR, Suárez M. Insect Sci. 2015 Apr;22(2):178-90. doi: 10.1111/1744-7917.12094. Epub 2014 Apr 30. PubMed PMID: 24339348.

Small-plasmid-mediated antibiotic resistance is enhanced by increases in plasmid copy number and bacterial fitnessSan Millan A, Santos-Lopez A, Ortega-Huedo R, Bernabe-Balas C, Kennedy SP, Gonzalez-Zorn B.Antimicrob Agents Chemother. 2015;59(6):3335-41. doi: 10.1128/AAC.00235-15. Epub 2015 Mar 30. PubMed PMID: 25824216; PubMed Central PMCID: PMC4432117.

2014

Prevalence and molecular characterisation of New Delhi metallo-β-lactamases NDM-1, NDM-5, NDM-6 and NDM-7 in multidrug-resistant Enterobacteriaceae from India. Rahman M, Shukla SK, Prasad KN, Ovejero CM, Pati BK, Tripathi A, Singh A, Srivastava AK, Gonzalez-Zorn B. Int J Antimicrob Agents. 2014 Jul;44(1):30-7. doi: 10.1016/j.ijantimicag.2014.03.003. Epub 2014 Apr 24. PubMed PMID: 24831713.

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