Publications

A macrophage ingests a Candida albicans cells that then, triggers the formation of a filament which in turn may allow the fungus to scape from a sure death.

Publications

Morphogenetic transitions in the adaptation of Candida albicans to the mammalian gut

The defective gut colonization of Candida albicans hog1 MAPK mutants is restored by overexpressing the transcriptional regulator of the white opaque transition WOR1

Overexpression of the White Opaque Switching Master Regulator Wor1 Alters Lipid Metabolism and Mitochondrial Function in Candida albicans

Comparative Analysis of the Fitness of Candida albicans Strains During Colonization of the Mice Gastrointestinal Tract

Adaptation to Endoplasmic Reticulum Stress in Candida albicans Relies on the Activity of the Hog1 Mitogen-Activated Protein Kinase

Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn's disease

Identification of Clinical Isolates of Candida albicans with Increased Fitness in Colonization of the Murine Gut

Candida albicans colonization of the gastrointestinal tract: A double-edged sword

The Glyoxylate Cycle Is Involved in White-Opaque Switching in Candida albicans

The protein kinase Ire1 impacts pathogenicity of Candida albicans by regulating homeostatic adaptation to endoplasmic reticulum stress

Hog1 Controls Lipids Homeostasis Upon Osmotic Stress in Candida albicans

The Fungicidal Action of Micafungin is Independent on Both Oxidative Stress Generation and HOG Pathway Signaling in Candida albicans

Characterization of a Candida albicans Mutant Defective in All MAPKs Highlights the Major Role of Hog1 in the MAPK Signaling Network

Cooperative Role of MAPK Pathways in the Interaction of Candida albicans with the Host Epithelium

The MAPK Hog1 mediates the response to amphotericin B in Candida albicans

Ifu5, a WW domain-containing protein interacts with Efg1 to achieve coordination of normoxic and hypoxic functions to influence pathogenicity traits in Candida albicans

Deletion of the SKO1 Gene in a hog1 Mutant Reverts Virulence in Candida albicans

New insights of CRISPR technology in human pathogenic fungi

The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway

Implementation of a CRISPR-Based System for Gene Regulation in Candida albicans

TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut

Non-canonical Activities of Hog1 Control Sensitivity of Candida albicans to Killer Toxins From Debaryomyces hansenii

CX3CR1⁺ mononuclear phagocytes control immunity to intestinal fungi

Overexpression of the Transcriptional Regulator WOR1 Increases Susceptibility to Bile Salts and Adhesion to the Mouse Gut Mucosa in Candida albicans

Arsenic inorganic compounds cause oxidative stress mediated by the transcription factor PHO4 in Candida albicans

Corrigendum: The Hog1 MAP Kinase Promotes the Recovery from Cell Cycle Arrest Induced by Hydrogen Peroxide in Candida albicans

The Hog1 MAP Kinase Promotes the Recovery from Cell Cycle Arrest Induced by Hydrogen Peroxide in Candida albicans

Role of catalase overproduction in drug resistance and virulence in Candida albicans

Serum Antibody Profile during Colonization of the Mouse Gut by Candida albicans: Relevance for Protection during Systemic Infection

The Candida albicans Pho4 Transcription Factor Mediates Susceptibility to Stress and Influences Fitness in a Mouse Commensalism Model

TLR2 modulates gut colonization and dissemination of Candida albicans in a murine model

The Cek1-mediated MAP kinase pathway regulates exposure of alpha-1,2 and beta-1,2-mannosides in the cell wall of Candida albicans modulating immune recognition

Adaptation of Candida albicans to commensalism in the gut

Complementary roles of the Cek1 and Cek2 MAP kinases in Candida albicans cell-wall biogenesis

The activity of RTA2, a downstream effector of the calcineurin pathway, is required during tunicamycin-induced ER stress response in Candida albicans

Distinct stages during colonization of the mouse gastrointestinal tract by Candida albicans

The Mkk2 MAPKK Regulates Cell Wall Biogenesis in Cooperation with the Cek1-Pathway in Candida albicans

The Pho4 transcription factor mediates the response to arsenate and arsenite in Candida albicans

The production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug

The lack of upstream elements of the Cek1 and Hog1 mediated pathways leads to a synthetic lethal phenotype upon osmotic stress in Candida albicans

The HOG pathway is critical for the colonization of the mouse gastrointestinal tract by Candida albicans

Mitochondria influence CDR1 efflux pump activity, Hog1-mediated oxidative stress pathway, iron homeostasis, and ergosterol levels in Candida albicans

The transmembrane protein Opy2 mediates activation of the Cek1 MAP kinase in Candida albicans

Msb2 shedding protects Candida albicans against antimicrobial peptides

Signaling the glycoshield: maintenance of the Candida albicans cell wall

The role of MAPK signal transduction pathways in the response to oxidative stress in the fungal pathogen Candida albicans: implications in virulence

MAPK cell-cycle regulation in Saccharomyces cerevisiae and Candida albicans

Adaptive tolerance to oxidative stress and the induction of antioxidant enzymatic activities in Candida albicans are independent of the Hog1 and Cap1-mediated pathways

The Sko1 protein represses the yeast-to-hypha transition and regulates the oxidative stress response in Candida albicans

Candida albicans beta-glucan exposure is controlled by the fungal CEK1-mediated mitogen-activated protein kinase pathway that modulates immune responses triggered through dectin-1

Román, E., D. Prieto, S. Hidalgo-Vico, R. Alonso-Monge and J. Pla (2023). "The defective gut colonization of Candida albicans hog1 MAPK mutants is restored by overexpressing the transcriptional regulator of the white opaque transition WOR1." Virulence 14(1): 2174294.
Ceballos-Garzon, A., E. Roman, J. Pla, F. Pagniez, D. Amado, C. J. Almeciga-Diaz, P. Le Pape and C. M. Parra-Giraldo (2022). "CRISPR-Cas9 approach confirms Calcineurin-responsive zinc finger 1 (Crz1) transcription factor as a promising therapeutic target in echinocandin-resistant Candida glabrata." PLoS One 17(3): e0265777.
Doron, I., M. Mesko, X. V. Li, T. Kusakabe, I. Leonardi, D. G. Shaw, W. D. Fiers, W. Y. Lin, M. Bialt-DeCelie, E. Roman, R. S. Longman, J. Pla, P. C. Wilson and I. D. Iliev (2021). "Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn's disease." Nat Microbiol 6(12): 1493-1504.
Hidalgo-Vico, S., J. Casas, C. Garcia, M. P. Lillo, R. Alonso-Monge, E. Roman and J. Pla (2022). "Overexpression of the White Opaque Switching Master Regulator Wor1 Alters Lipid Metabolism and Mitochondrial Function in Candida albicans." J Fungi (Basel) 8(10).
Husain, F., P. Pathak, E. Román, J. Pla and S. L. Panwar (2022). "Adaptation to Endoplasmic Reticulum Stress in Candida albicans Relies on the Activity of the Hog1 Mitogen-Activated Protein Kinase." Front Microbiol 12: 794855.
Prieto, D. and J. Pla (2022). "Comparative Analysis of the Fitness of Candida albicans Strains During Colonization of the Mice Gastrointestinal Tract." Methods Mol Biol 2542: 233-244.
Sircaik, S., E. Román, P. Bapat, K. K. Lee, D. R. Andes, N. A. R. Gow, C. J. Nobile, J. Pla and S. L. Panwar (2021). "The protein kinase Ire1 impacts pathogenicity of Candida albicans by regulating homeostatic adaptation to endoplasmic reticulum stress." Cellular Microbiology 23(5): e13307.
Vico, S. H., D. Prieto, R. A. Monge, E. Roman and J. Pla (2021). "The Glyoxylate Cycle Is Involved in White-Opaque Switching in Candida albicans." J Fungi (Basel) 7(7).
Guirao-Abad JP, Sanchez-Fresneda R, Roman E, Pla J, Arguelles JC, Alonso-Monge R. The MAPK Hog1 mediates the response to amphotericin B in Candida albicans. Fungal Genet Biol. 2020;136:103302. Epub 2019/11/23. doi: 10.1016/j.fgb.2019.103302. PubMed PMID: 31756382.
Urrialde V, Prieto D, Hidalgo-Vico S, Román E, Pla J, Alonso-Monge R. Deletion of the SKO1 Gene in a hog1 Mutant Reverts Virulence in Candida albicans. J Fungi (Basel). 2019;5(4). Epub 2019/11/17. doi: 10.3390/jof5040107. PubMed PMID: 31731583.
Román E, Prieto D, Alonso-Monge R, Pla J. New insights of CRISPR technology in human pathogenic fungi. Future Microbiol. 2019;14:1243-55. Epub 2019/10/19. doi: 10.2217/fmb-2019-0183. PubMed PMID: 31625446.
Román E, Correia I, Prieto D, Alonso R, Pla J. The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway. Int Microbiol. 2019. Epub 2019/03/16. doi: 10.1007/s10123-019-00069-1. PubMed PMID: 30875035.
Román E, Coman I, Prieto D, Alonso-Monge R, Pla J. Implementation of a CRISPR-Based System for Gene Regulation in Candida albicans. mSphere. 2019;4(1). Epub 2019/02/15. doi: 10.1128/mSphere.00001-19. PubMed PMID: 30760608; PubMed Central PMCID: PMCPMC6374588.
Rastogi SK, van Wijlick L, Ror S, Lee KK, Román E, Agarwal P, et al. Ifu5, a WW domain-containing protein interacts with Efg1 to achieve coordination of normoxic and hypoxic functions to influence pathogenicity traits in Candida albicans. Cell Microbiol. 2019:e13140. Epub 2019/11/19. doi: 10.1111/cmi.13140. PubMed PMID: 31736226.
Correia I, Prieto D, Román E, Wilson D, Hube B, Alonso-Monge R, et al. Cooperative Role of MAPK Pathways in the Interaction of Candida albicans with the Host Epithelium. Microorganisms. 2019;8(1). Epub 2019/12/29. doi: 10.3390/microorganisms8010048. PubMed PMID: 31881718.
Valderrama MJ, Gonzalez-Zorn B, de Pablo PC, Diez-Orejas R, Fernandez-Acero T, Gil-Serna J, et al. Educating in antimicrobial resistance awareness: adaptation of the Small World Initiative program to service-learning. FEMS Microbiol Lett. 2018;365(17). Epub 2018/07/10. doi: 10.1093/femsle/fny161. PubMed PMID: 29982335.
Román E, Huertas B, Prieto D, Diez-Orejas R, Pla J. TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut. Future Microbiol. 2018;13:857-67. Epub 2018/06/08. doi: 10.2217/fmb-2018-0012. PubMed PMID: 29877100.
Morales-Menchen A, Navarro-Garcia F, Guirao-Abad JP, Román E, Prieto D, Coman IV, et al. Non-canonical Activities of Hog1 Control Sensitivity of Candida albicans to Killer Toxins From Debaryomyces hansenii. Front Cell Infect Microbiol. 2018;8:135. Epub 2018/05/19. doi: 10.3389/fcimb.2018.00135. PubMed PMID: 29774204; PubMed Central PMCID: PMCPMC5943613.
Leonardi, I., X. Li, A. Semon, D. Li, I. Doron, G. Putzel, A. Bar, D. Prieto, M. Rescigno, D. P. B. McGovern, J. Pla and I. D. Iliev (2018). "CX3CR1(+) mononuclear phagocytes control immunity to intestinal fungi." Science 359(6372): 232-236.
Huertas, B., D. Prieto, A. Pitarch, C. Gil, J. Pla and R. Diez-Orejas (2017). "Serum Antibody Profile during Colonization of the Mouse Gut by Candida albicans: Relevance for Protection during Systemic Infection." J Proteome Res 16(1): 335-345.
Urrialde, V., B. Alburquerque, J. P. Guirao-Abad, J. Pla, J. C. Argüelles and R. Alonso-Monge (2017). "Arsenic inorganic compounds cause oxidative stress mediated by the transcription factor PHO4 in Candida albicans." Microbiological Research 203: 10-18.
Prieto, D., E. Roman, R. Alonso-Monge and J. Pla (2017). "Overexpression of the Transcriptional Regulator WOR1 Increases Susceptibility to Bile Salts and Adhesion to the Mouse Gut Mucosa in Candida albicans." Front Cell Infect Microbiol 7: 389.
Mesa-Arango, A. C., C. Rueda, E. Roman, J. Quintin, M. C. Terron, D. Luque, M. G. Netea, J. Pla and O. Zaragoza (2016). "Cell wall changes in AmB-resistant strains from Candida tropicalis and relationship with the immune responses elicited by the host." Antimicrobial Agents and Chemotherapy 60(4): 9.
Correia, I., E. Roman, D. Prieto, B. Eisman and J. Pla (2016). "Complementary roles of the Cek1 and Cek2 MAP kinases in Candida albicans cell-wall biogenesis." Future Microbiology 11: 51-67.
Roman, E., I. Correia, A. Salazin, C. Fradin, T. Jouault, D. Poulain, F. T. Liu and J. Pla (2016). "The Cek1-mediated MAP kinase pathway regulates exposure of a-(1,2) and b-(1,2)-mannosides in the cell wall of Candida albicans modulating immune recognition." Virulence 7(5): 558-577.
Prieto, D., I. Correia, J. Pla and E. Roman (2016). "Adaptation of Candida albicans to commensalism in the gut." Future Microbiol 11: 567-583.
Prieto, D., N. Carpena, V. Maneu, M. L. Gil, J. Pla and D. Gozalbo (2016). "TLR2 modulates gut colonization and dissemination of Candida albicans in a murine model." Microbes Infect 18(10): 656-660.
Roman, E., D. Prieto, R. Martin, I. Correia, A. C. Mesa Arango, R. Alonso-Monge, O. Zaragoza and J. Pla (2016). "Role of catalase overproduction in drug resistance and virulence in Candida albicans." Future Microbiol.
Correia, I., R. Alonso-Monge and J. Pla (2016). "The Hog1 MAP Kinase Promotes the Recovery from Cell Cycle Arrest Induced by Hydrogen Peroxide in Candida albicans." Front Microbiol 7: 2133.
Urrialde, V., D. Prieto, J. Pla and R. Alonso-Monge (2016). "The Candida albicans Pho4 Transcription Factor Mediates Susceptibility to Stress and Influences Fitness in a Mouse Commensalism Model." Front Microbiol 7: 1062.
Urrialde, V., D. Prieto, J. Pla and R. Alonso-Monge (2015). "The Pho4 transcription factor mediates the response to arsenate and arsenite in Candida albicans." Frontiers in Microbiology 6: 118.
Román, E., R. Alonso-Monge, A. Miranda and J. Pla (2015). "The Mkk2 MAPKK Regulates Cell Wall Biogenesis in Cooperation with the Cek1-Pathway in Candida albicans." PLoS ONE 10(7): e0133476.
Prieto, D. and J. Pla (2015). "Distinct stages during colonization of the mouse gastrointestinal tract by Candida albicans." Frontiers in Microbiology 6: 792.
Garcia-Rodas, R., N. Trevijano-Contador, E. Roman, G. Janbon, F. Moyrand, J. Pla, A. Casadevall and O. Zaragoza (2015). "Role of Cln1 during melanization of Cryptococcus neoformans." Frontiers in Microbiology 6: 798.
Thomas, E., S. Sircaik, E. Roman, J. M. Brunel, A. K. Johri, J. Pla and S. L. Panwar (2015). "The activity of RTA2, a downstream effector of the calcineurin pathway, is required during tunicamycin-induced ER stress response in Candida albicans." FEMS Yeast Research 15(8).
Prieto, A. D., E. Román, I. Correia and J. Pla (2014). "The HOG pathway is critical for the colonization of the mouse gastrointestinal tract by Candida albicans." PLoS ONE 9(1): e87128.
Olombrada, M., M. Rodriguez-Mateos, D. Prieto, J. Pla, M. Remacha, A. Martinez-del-Pozo, J. G. Gavilanes, J. P. Ballesta and L. Garcia-Ortega (2014). "The acidic ribosomal stalk proteins are not required for the highly specific inactivation exerted by alpha-sarcin of the eukaryotic ribosome." Biochemistry 53(10): 1545-1547.
Herrero-de-Dios, C., R. Alonso-Monge and J. Pla (2014). "The lack of upstream elements of the Cek1 and Hog1 mediated pathways leads to a synthetic lethal phenotype upon osmotic stress in Candida albicans." Fungal Genet Biol 69: 31-42.
Mesa-Arango, A. C., N. Trevijano-Contador, E. Roman, R. Sanchez-Fresneda, C. Casas, E. Herrero, J. C. Arguelles, J. Pla, M. Cuenca-Estrella and O. Zaragoza (2014). "The production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug." Antimicrob Agents Chemother 58(11): 6627-6638.
Herrero de Dios, C., E. Román, C. Diez, R. Alonso-Monge and J. Pla (2013). "The transmembrane protein Opy2 mediates activation of the Cek1 MAP kinase in Candida albicans." Fungal Genetics and Biology 50: 21-32.
Román, E. and J. Pla (2013). "The CEK1-mediated mitogen-activated protein kinase pathway in the fungal pathogen Candida albicans." MAP Kinase 12(1).
Thomas, E., E. Roman, S. Claypool, N. Manzoor, J. Pla and S. L. Panwar (2013). "Mitochondria influence CDR1 efflux pump activity, Hog1-mediated oxidative stress pathway, iron homeostasis, and ergosterol levels in Candida albicans." Antimicrobial Agents and Chemotherapy 57(11): 5580-5599.
Szafranski-Schneider, E., M. Swidergall, F. Cottier, D. Tielker, E. Román, J. Pla and J. F. Ernst (2012). "Msb2 shedding protects Candida albicans against antimicrobial peptides." PLoS Pathogens 8(2): e1002501.

Jesús Pla's Google Scholar

This yeast is able to form germ tubes upon defined experimental conditions. Such property, called dimorphism, contributes to the abilty of the fungus to colonize defined host niches and illustrates the versatilty of the life style of this pathobiont.