2012-2007

M. Dolores Blanco, César Teijón, Rosa M. Olmo and José M. Teijón. "Targeted nanoparticles for cancer therapy". In: “Recent Advances in Novel Drug Carrier Systems", Ali Demir Sezer Ed., InTech, 2012, Chapter 9, pp 241-278 (ISBN 979-953-307-1092-8).

M.D. Blanco, M. Benito, R. Olmo, C. Teijón,  E. Pérez, I. Katime, J.M. Teijón. Synthesis and in vitro biological evaluation as antitumor drug carriers of folate-targeted N- isopropylacrylamide-based nanohydrogels. Polymer International  61: 1202-1212 (2012).

A. Fernández, C. Teijón, M. Benito, I. Iglesias, R. Lozano, J.M. Teijón, M.D. Blanco. Tamoxifen-loaded microspheres based on mixtures of poly(D,L-lactide-co-glycolide) and poly(D,L-lactide) polymers: effect of polymeric composition on drug release and  in vitro antitumoral activity.J Appl Polym Sci 124(4): 2987-98 (2012)

A. Martínez, M. Benito-Miguel, I. Iglesias,J.M. Teijón and M.D. Blanco. Tamoxifen-loaded thiolated alginate-albumin nanoparticles as antitumoral drug delivery systems. J Biomed Mater Res Part A  100A (6):1467-1476 (2012)

A.M. Fernández, A.M. Martínez, S. Guerrero, M. Benito, E. Pérez and M.D. Blanco. Drug–loaded microspheres of poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) polymers prepared by spray-drying: characterization and in vivo administration. En:  “Polylactic Acid: Synthesis, Properties and Applications"; Piemonte Vincenzo (Ed.); 2012 Nova Science Publishers, Inc., Chapter 13, pp. 275-307. (ISBN: 978-1-62100-383-0 e-book; ISBN: 978-1-62100-348-9 hardcover).

M.D. Blanco, S. Guerrero, M. Benito, A.Fernández, C. Teijón, R. Olmo, I. Katime and J.M. Teijón. In Vitro And In Vivo Evaluation Of A Folate-Targeted Copolymeric Nanohydrogel Based On N-Isopropylacrylamide As 5-Fluorouracil Delivery System. Polymers 2011, 3(3), 1107-1125; doi:10.3390/polym3031107 (Special Issue Polymer Nanogels and Microgels)  (ISSN 2073-4360; www.mdpi.com/journal/polymers)

A. Martínez, A. Fernández, E. Pérez, M. Benito, J.M. Teijón, M.D. Blanco. "Polysaccharide-Based Nanoparticles For Controlled Release Formulations" In: “Nanoparticles / Book 2", ISBN 979-953-307-859-4."; Abbass Hashim Ed., InTech 2012, pp 185-222 (www.intechweb.org)

E. Pérez, M. Benito, C. Teijón, R. Olmo J.M. Teijón and M.D. Blanco. Tamoxifen-loaded nanoparticles based on a novel mixture of biodegradable polyesters: characterization and in vitro evaluation as sustained release systems. Journal of Microencapsulation 29 (4): 309–322 (2012)

Clara Gómez, Marta Benito, Issa Katime, José María Teijón, Maria Dolores Blanco. In vitro transdermal and biological evaluation of ALA-loaded poly(N-isopropylacrylamide) and poly(N-isopropylacrylamide-co-acrylic acid) microgels for photodynamic therapy. Journal of Microencapsulation   29(7): 626–635 (2012)

C. Gómez, M. Benito, J.M. Teijón and M.D. Blanco. Novel methods and devices to enhance transdermal drug delivery. Importance of the laser radiation in transdermal drug delivery. Therapeutic Delivery 3 (3): 373-388 (2012) .

C. Gómez, A. Costela, I. García-Moreno, F. Llanes, J.M. Teijón and M.D. Blanco. Skin laser treatments enhancing transdermal delivery of ALA. J Pharm Sci 100 (1): 223-231 (2011); DOI: 10.1002/jps.22270

A. Martínez, I. Iglesias, R. Lozano, J.M. Teijón and M.D. Blanco. Synthesis and characterization of thiolated alginate-albumin nanoparticles stabilized by disulfide bonds. Evaluation as drug delivery systems. Carbohydrate Polymers 83: 1311-1321 (2011); DOI: 10.1016/j.carbpol.2010.09.038

P. López-Gasco, I. Iglesias, J. Benedí, R. Lozano, J.M. Teijón and M.D. Blanco. Paclitaxel-loaded polyester nanoparticles prepared by spray-drying technology. In vitro bioactivity evaluation. Journal of Microencapsulation  28 (5): 417-429 (2011)

C. Teijón, M.D. Blanco, C.S. Romero, J.V. Beneit, A.L. Villarino, S. Guerrero  and R. Olmo. Study of response of thymic and submaxillary lymph node lymphocytes to administration of lead by different routes.  Biol Trace Elem Res, 135: 74-85 (2010), DOI 10.1007/s12011-009-8495-6

S. Guerrero,  C. Teijón, E. Muñíz, J.M. Teijón and M.D. Blanco. Characterization and in vivo evaluation of ketotifen-loaded chitosan microspheres. Carbohydrate Polymers 79: 1006-1013 (2010), DOI: 10.1016/j.carbpol.2009.10.034

M.D. Blanco, S. Guerrero,  M. Benito, C. Teijón, R. Olmo, E. Muñíz, I. Katime, J.M. Teijón. Tamoxifen-loaded folate-conjugate poly[(p-nitrophenyl acrylate)-co-(N-isopropylacrylamide)] nanogel as antitumoral drug delivery system. J Biomed Mater Res Part A  95A: 1028-1040  (2010)

N. Davidenko, M.D. Blanco, C. Peniche, L. Becherán, S. Guerrero,  J.M. Teijón. Effect of different parameters on characteristics of chitosan-poly(acrylic acid) nanoparticles obtained by the method of coacervation. J Appl Polym Sci 111: 2362-2371 (2009), DOI: 10.1002/app.29231

C. Teijón,  S. Guerrero, R. Olmo, J.M. Teijón and M.D. Blanco. Swelling properties of copolymeric hydrogels of poly(ethylene glycol) monomethacrylate and monoesters of itaconic acid for use in drug delivery. J Biomed Mater Res B-Applied Biomaterials 91(2): 716-726 (2009), DOI: 10.1002/jbm.b.31448

S. Guerrero, E. Muñíz, C. Teijón, R. Olmo, J.M. Teijón and M.D. Blanco. Ketotifen –loaded microspheres prepared by spray-drying poly(D-L-lactide) and poly (D,L-lactide-co-glycolide) polymers: characterization and in vivo administration. J Pharm Sci 97 (8): 3153-3169 (2008) DOI: 10.1002/jps.21241 

Clara Gómez, Ángel Costela, Inmaculada García-Moreno, Felipe Llanes, José M. Teijón and Dolores Blanco. Laser Treatments on Skin Enhancing and Controlling Transdermal Delivery of 5-Fluorouracil. Laser Surg Med 40:6–12 (2008); DOI 10.1002/lsm.20590

F. Sánchez-Patán, M.A. Aller, C. Cuellar, M. Rodero, M.T. Corchera, M.P. Nava, F. Gómez, M.D. Blanco, S. Guerrero, R. Anchuelo, E. Muñíz, M.J. Alonso, J.M. Teijón, J. Arias. Mast cell inhibition by ketotifen reduces splanchnic inflammatory response in a portal  hypertension model in rats.  Exp Toxicol Pathol 60: 347-355 (2008) (DOI: 10.1016/j.etp.2008.03.008)

M.D. Blanco, S. Guerrero, C. Teijón, R. Olmo, L. Pastrana, I. Katime, J.M. Teijón. Preparation and characterization of nanoparticulated poly(N-isopropylacrylamide) hydrogel for the controlled release of anti-tumour drugs. Polym Int 57 (11):1215-1225 (2008) DOI: 10.1002/pi.2457;  Erratum: Polym Int 58: 116, 2009

L.A. Arraez-Aybar, J. Millan, D. Carabantes, R. Lozano, I. Iglesias, E. Palacios, B del Castillo y A. Nogales Jornadas Complutenses de investigación para alumnos en ciencias de la salud: una experiencia positiva Educación Medica 10(3): 165 (2008)

L.A. Arraez-Aybar, J. Millan, D. Carabantes, R. Lozano, I. Iglesias, E. Palacios, B del Castillo y A. Nogales Adquisición de competencias transversales en alumnos de pregrado de ciencias de la salud en la Universidad Complutense de Madrid: una experiencia positiva Educación Medica 11(3): 169-177 (2008)

R. Lozano, F. de Jesús, M. Cano and M.C. Lozano Synthesis, characterization, thermal decomposition, and kinetic studies of binuclear sulfur-coordinated Tungsten(v) complexes with piperidine-1-carbodithioate. Helvetica Chimica Acta 8(91:1567-1577 (2008)

R.L. Sastre, R. Olmo C. Teijón, E. Muñíz, J.M. Teijón and M.D. Blanco. 5-Fluorouracil plasma levels and biodegradation of subcutaneously injected drug-loaded microspheres prepared by spray-drying poly(D-L-lactide) and poly (D,L-lactide-co-glycolide) polymers. Int J Pharm 338: 180-190 (2007)

 

2006-2002

C. Teijón, R. Olmo, M.D. Blanco, J.M. Teijón, A. Romero. Effect of the crosslinking degree and the nickel salt load on the thermal decomposition of poly(2-hydroxyethyl methacrylate) hydrogels and on the metal release from them. J Colloid Interf Sci.  295: 393-400 (2006)

C. Teijón, R. Olmo, M.D. Blanco, A. Romero and J.M. Teijón. Low doses of lead: Effects on reproduction and development in rats. Biol Trace Element Res 111: 151-165 (2006)    .

M.D. Blanco, R.L. Sastre, C. Teijón, R. Olmo and  J.M. Teijón. Degradation behaviour of microspheres prepared by spray-drying poly(D-L-lactide) and poly (D,L-lactide-co-glicolide) polymers. Int. J Pharm 326: 139-147 (2006).

R. Lozano, F. de Jesús and M.C. Lozano. Synthesis, spectral, thermal and kinetic studies on the adducts with pyridines of tungsten(v) binuclear thiocomplexes with di-isopropyl-dithiocarbamate  Polyhedron 16(25): 3127-3132 (2006)

J.L. Lopez Colon and R. Lozano. Determination of mercury levels in blood and urine of occupationally exposed workers using flow injection with cold vapour AAS Atomic Spectroscopy 3(27): 98-105 (2006)

M.D. Blanco, R.L. Sastre, C. Teijón, R. Olmo and J.M. Teijón. 5-Fluorouracil-loaded microspheres prepared by spray-drying poly(D-L-lactide) and poly (lactide-co-glicolide) polymers: characterization and drug release.J.  Microencapsulation 22: 671-682 (2005).

C.S. Romero, R. Olmo, C. Teijón, M.D. Blanco, J.M. Teijón, A. Romero. Structural and Functional Implications of the Hexokinase-Nickel Interaction. J. Inorg. Biochem.  99: 2395-2402 (2005)

C. Gómez,  M.D. Blanco, M.V. Bernardo, R. Olmo, E. Muñíz and J.M. Teijón. Cytarabine release from comatrices of albumin microspheres in a poly(lactide-co-glycolide) film: in vitro and in vivo studies. Eur. J. Pharm. Biopharm 57: 225-233 (2004)

M.D. Blanco, R. Olmo, y J.M. Teijón. Biomateriales: Hidrogeles. En: Propedéutica Quirúrgica . Editorial Tebar  (2004), pp- 551-568

R.L. Sastre, M.D. Blanco, C. Teijón, R. Olmo and J.M. Teijón. Preparation and Characterization of 5-Fluorouracil-loaded Poly(e-caprolactone) Microspheres for Drug Administration. Drug Develop Res 63: 41-53 (2004)

R. Lozano, I. Iglesias, MC Abad, M. Alfonsel y B. del Castillo What a pharmacist needs to know about medical devices Pharmacy Education  4 (3/4): 181-185 (2004)

M.D. Blanco, M.V. Bernardo, C. Teijón, R.L. Sastre and J.M. Teijón. Transdermal application of bupivacaine-loaded poly(acrylamide-co-monomethyl itaconate) hydrogels. Int. J. Pharm. 255: 99-107 (2003)

M.D. Blanco, M.V. Bernardo, R.L. Sastre, R. Olmo, E. Muñíz and J.M. Teijón. Preparation of bupivacaine-loaded poly(e-caprolactone) microspheres by spray drying: drug release studies and biocompatibility. Eur. J. Pharm. Biopharm. 55: 229-236 (2003)

M.V. Bernardo, M.D. Blanco, R.L. Sastre, C. Teijón and J.M. Teijón. Sustained release of bupivacaine from devices based on chitosan.Il Farmaco 58: 1187-1191 (2003)

C. Teijón, R. Olmo, M.D. Blanco, A. Romero and J.M. Teijón. Effects of lead administration at low doses by different routes on rat spleens. Study of response of splenic lynphocytes and tissue lysozyme. Toxicology 191: 245-258 (2003).

M.V. Bernardo, M.D. Blanco, R. Olmo and J.M. Teijón. Delivery of bupivacaine included in poly(acrylamide-co-monomethyl itaconate) hydrogels as a function of pH-swelling medium. Journal of Applied Polymer Science 86: 327-334 (2002)

R. Olmo, M.D. Blanco, C. Teijón, J. M. Socorro and J.M. Teijón. Studies of cadmium binding to hexokinase: structural and functional implications. Journal Inorganic Biochemistry 89: 107-114 (2002)

M.D. Blanco, R. Olmo and J.M. Teijón. Hydrogels. En: Encyclopedia of Pharmaceutical Technology.James Swarbrick,  Ed., 2002;  Marcel Dekker, Inc. U.S.A. Pag: 1-21

M.D. Veiga, M. Merino, D. Fernández y R. Lozano Characterization of some cyclodextrin derivatives by thermal analysis. Journal of Thermal Analysis and Calorimetry 68: 511-516 (2002)

 

2001-1997

R. Olmo, M.D. Blanco, J.M. Socorro, J.A. Martín and J.M. Teijón. Effect of cadmium acetate on conformation of lysozyme: functional implications. J. Enzyme Inhibition 16: 65-80 (2001)

C. Teijón, R. Olmo, J.M. Socorro, M.D. Blanco,A. Romero and J.M. Teijón Lead-yeast hexokinase interaction: modifications on protein structure caused by the metal. Polymer International 50: 822-827 (2001).  

J.L. López Colón, D. Veiga, A. Montel, J.M. Prádena y R. Lozano  Determination of mercury in blood by cold vapor atomic spectrometry. Atomic Spectroscopy 22 (2): 284-289 (2001)

O. García, M.D. Blanco, J.A. Martín and J.M. Teijón. 5-fluorouracil trapping in poly(2-hydroxyethyl methacrylate-co-acrylamide) hydrogels: In vitro drug delivery studies. Eur. Polym. J. 36: 111-122 (2000)

M.V. Bernardo, M.D. Blanco, C. Gómez, R. Olmo and J.M. Teijón. In vitro controlled release of bupivacaine from albumin microspheres and a comatrix formed by microspheres in a poly(lactide-co-glycolide) film. J. Microencapsulation 17: 721-731 (2000)

M.D. Blanco, C.Gómez, R.Olmo, E.Muñiz y J.M. Teijón. Chitosan microspheres in PLG films as devices for cytarabine release. International Journal of Pharmaceutics 202: 29-39 (2000)       

J.M. Socorro, R. Olmo, C. Teijón, M.D. Blanco and J.M. Teijón. Analysis of Aluminum-Yeast Hexokinase Interaction: Modifications on Protein Structure and Funcionality.J. Protein Chemistry 19: 199-208 (2000) 

R. Olmo,M.D. Blanco y J.M. Teijón. Inclusión de sales metálicas en hidrogeles biocompatibles: cinética de liberación de cadmio (II). Rev. R. Acad. Cienc.Exact. Fis. Nat. 94: 121-130 (2000)

M.D. Blanco, O. García, C. Gómez, R.L. Sastre and J.M. Teijón. In vivo drug delivery of 5-Fluorouracil using poly(2-hydroxyethyl methacrylate-co-acrylamide) hydrogels.J. Pharm. Pharmacol. 52: 1319-1325 (2000)

J.M. Teijón, R. Olmo y M.D. Blanco. Hidrogeles: Propiedades generales. En: Biomateriales: Aquí y Ahora. M.V. Regí y L. Munuera Eds., 2000; pp. 59-65. Ed. Dykinson, Madrid.     

R.L. Sastre, M.D. Blanco, C. Gómez, J.M. Socorro and J.M. Teijón. Cytarabine trapping in poly(2-hydroxyethyl methacrylate-co-acrylamide) hydrogels: drug delivery studies. Polymer International 48: 843-850 (1999)

M.D. Blanco, M.V. Bernardo, C. Gómez, E. Muñiz  and J.M. Teijón. Bupivacaine-loaded comatrix formed by albumin microspheres included in a poly(lactide-co-glycolide) film: in vivo biocompatibility and drug release studies. Biomaterials 20: 1919-1924 (1999).

M.D. Blanco C. Gómez, O. García and J.M. Teijón. Ara-C release from Poly(acrylamide-co-monomethyl itaconate) Hydrogels: "in vitro" and "in vivo" studies. Polymer Gels and Networks 6: 57-69 (1998)

C. Gómez, M.D. Blanco, M.V. Bernardo, R.L. Sastre and J.M. Teijón. Poly(acrylamide-co-monoethyl itaconate) hydrogels as devices for cytarabine release. J. Pharm. Pharmacol.  50: 703-712 (1998)

M.D. Blanco, R,M, Trigo, C. Teijón, C. Gómez and J.M. Teijón. Slow releasing of Ara-C from Poly(2-Hydroxyethyl Metacrylate) and Poly(2-Hydroxyethyl Methacrylate-co-N-Vinyl-2-Pyrrolidone) Hydrogels implanted subcutaneously in the back of rats. Biomaterials  19, 861-869 (1998)

R. Olmo, M.D. Blanco, C. Teijón, J.M. del Socorro and J.M. Teijón. Modifications induced by zinc, cadmium and mercury acetates on hexokinase in aqueous solutions. Polymer International 47: 179-185 (1998)

J.M. Teijón, R.M. Trigo, O. García and M. D. Blanco. Cytarabine trapping in poly(2-hydroxyethyl methacrylate) hydrogels: drug delivery studies. Biomaterials 18, 383-388 (1997).

M. Lozano, M.D. Blanco, R. Olmo, R. Lozano and J.M. Teijón. Viscosity behaviour of Poly(N-vinyl-2-pyrrolidone) in the water/VOSO₄ binary mixtrure: Preferential interactions. Polym. Int. 42: 245-250 (1997).

M Lozano, M.D. Blanco, R. Lozano, E. Muñíz and J.M. Teijón. Study of the poly(N-vinyl-2-pyrrolidone)-Na2MoO4 interactions in aqueous solution: Effect on the polymer morphology. Eur. Polym. J. 33: 391-397 (1997).

J.A. Martín, R. Olmo, J.M. del Socorro, M.D. Blanco and J.M. Teijón. Influence of the lysozyme-LiCl interaction in aqueous solution on protein conformation and function. Polym. Int. 42: 218-224 (1997).

O. García, M.D. Blanco C. Gómez and J.M. Teijón. Effect of the crosslinking with 1,1,1-trimethylolpropane trimethacrylate on 5-fluorouracil release from poly(2-hydroxyethyl methacrylate) hydrogels.Polym. Bull. 38: 55-62 (1997).

M.D. Blanco, R.M. Trigo, O. García and J.M. Teijón. Controlled release of cytarabine from Poly(2-hydroxyethyl methacrylate-co-N-vynil-2-pyrrolidone) Hydrogels. J. Biomater. Sci. Polymer Edn. 8, 709-719 (1997)

M. Lozano, M.D. Blanco, E. Muñiz, R. Lozano and J.M. Teijón. Conformational and Morphological Changes in Poly(N-vinyl-2-pyrrolidone) induced by MoCl₅. Polymer Journal 29(7): 611-616 (1997)