Innate Lymphoid Cells

Molecular mechanisms regulating ILC3 immune responses

 

Research interests

The discovery of antibiotics has transformed modern medicine and saved millions of lives. However, the indiscriminate use of antibiotics has given rise to bacterial resistance worldwide and the spread of immune disorders due to the alteration of the microbiota composition. Innate lymphoid cells (ILCs) represent the most recently identified branch of tissue-resident immune cells. These cells play essential roles in maintaining microbiota, protecting the tissue barrier against invading pathogens and regulating inflammatory disease. Consequently, an understanding of the cellular and molecular mechanisms regulating ILC function during an infection or inflammatory diseases is vital with regard to designing new treatments or tools for diagnosis. At Dr. Aranzazu Cruz-Adalia’s lab we are attempting to decipher the cellular, molecular and metabolic mechanisms by which ILC3s are regulated in physiological conditions and during enteric pathogen infections or intestine-associated inflammatory disorders.

 

Group members

                 

Principal investigator: 

Aranzazu Cruz Adalia

Assistant Professor:

Dr. Lara del Campo Milán

PhD students:

Ana Valle Noguera

Master's student:

Marina Marsá Ávila

Technician:

María Jose Gomez

Undergraduate student: 

Yago Rodriguez Carreras

Scientist Advisors of the team:

Dr. Jose Ramón Regueiro- Catedrático 

Dr. Eduardo Martinez Naves- Catedrático 

Dr. Jose María González Granado- Investigador Distinguido del imas12

Dr. Estela Paz Artal - Jefa del Servicio de Inmunología del Hospital 12 de Octubre

Team of collaborators: 

Dr. Mª Jesús Fernández Aceñero (Departamento de Patología Digestiva, Hospital Clínico)

Dr. Raquel Castillo (Hospital de la Princesa)

Dr. Pu Xia (National Center For radiation research, Germany)

 

Training Opportunities

-       Postdoctoral Fellows

We welcome postdocs to apply the UNA4CAREER fellow (https://www.una-europa.eu/una4career/). Interested candidates should inquire by email to arancruz@ucm.es. Please attach your curriculum vitae, a PDF of any recent publication(s) and the names and email addresses of two professional references. 

-       PhD or MD/PhD Students

Students interested should inquire by email to arancruz@ucm.es

 

Last publications

- Calatayud DG, Jardiel T, Cordero-Oyonarte E, Caballero AC, Villegas M, Valle-Noguera A, Cruz-Adalia A, Peiteado M. Biocompatible Probes Based on Rare-Earth Doped Strontium Aluminates with Long-Lasting Phosphorescent Properties for In Vitro Optical IMAGING. Int J Mol Sci. 2022 Mar 21;23(6):3410. doi: 10.3390/ijms23063410.

-Valle-Noguera A, Ochoa-Ramos A, Gómez-Sánchez MJ, Girard-Madoux MJH, Cruz-Adalia A. Type 3 innate lymphoid cells as regulators of the host-pathogen interaction.  Front Immunol. 2021; 12:748851

- Piperoglou C, Larid G, Vallentin B, Balligand L, Crinier A, Banzet N, Farnarier C, Gomez-Massa E, Cruz-Adalia A; CRYOSTEM Consortium, Michel G, Galambrun C, Barlogis V, Vivier E, Vély F. Innate lymphoid cell recovery and occurence of GvHD after hematopoietic stem cell transplantation. J Leukoc Biol. 2021. doi: 10.1002/JLB.5A1019-522RR.

- Valle-Noguera A, Gómez-Sánchez MJ, Girard-Madoux MJH, Cruz-Adalia A. Optimized protocol for characterization of mouse gut innate lymphoid cells. Front Immunol. 2020; 11: 563414.

- Cruz-Adalia A*, Ramirez-Santiago G; Osuna Perez J; Torres-Torresano M; Zorita V; Martinez-Riaño A; Boccasavia V; Borroto A; Martinez del Hoyo G; Gonzalez-Granado JM; Alarcón B; Sánchez-Madrid F; Veiga E. Conventional CD4⁺ T cells present bacterial antigens to induce cytotoxic and memory CD8⁺ T cell responses. Nat Commun. 2017. 8(1) – 1591. *Co-corresponding author

- Cruz-Adalia A*; Veiga E*. Close encounters of lymphoid cells and bacteria. Front Immunol. 2016. 7 – 405. *Co-corresponding author

- Ramírez Santiago, G.; et al. Clathrin regulates lymphocyte migration by driving actin accumulation at the cellular leading edge. Eur J Immunol. 2016. 46(10):2376-2387.

- Cruz-Adalia A, Ramirez-Santiago G; Calabia-Linares C; Torres-Torresano M; Feo L; Galán-Díez M; Fernández Ruiz E; Pereiro E; Guttmann P; Chiappi M; Schneider G; López-Carrascosa J; Chichón FJ; Del Hoyo GM; Sánchez-Madrid F; Veiga E. T cells kill bacteria captured by transinfection from dendritic cells and confer protection in mice. Cell Host Microbe. 2014. 15 (5): 611-33.

Current fundings