B cell physiopathology (Yebenes VG)
Functional contribution of microRNAs to oncogenic B cell transformation.
- To characterize molecular mechanisms underlying the tumor-suppressor properties of miR-28, a GC-specific miRNA whose expression is reduced in several types of primary B cell lymphomas that originate in GC B cells, including the aggressive Burkitt lymphoma (BL) and Diffuse Large B Cell Lymphoma (DLBCL).
- To determine the impact of AID mutagenic activity on miRNA repertoire and its contribution to mature B cell transformation by promoting the escape from miRNA posttranscriptional gene expression regulation.
miR28-based combination therapy impairs aggressive B Cell Lymphoma growth by rewiring DNA replication
microRNA fine-tuning of the germinal center response
miRNA-based therapies in non-Hodgkin lymphoma: advances and future challenges
- Proyecto de investigación CONTRIBUCION FUNCIONAL DE LOS MICROARNS A LA TRANSFORMACION NEOPLASICA DE LINFOCITOS B (PID2019-107551RB-I00)