Departamentos

B cell physiopathology (Yebenes VG)

Functional contribution of microRNAs to oncogenic B cell transformation.


  1.  To characterize molecular mechanisms underlying the tumor-suppressor properties of miR-28, a GC-specific miRNA whose expression is reduced in several types of primary B cell lymphomas that originate in GC B cells, including the aggressive Burkitt lymphoma (BL) and Diffuse Large B Cell Lymphoma (DLBCL).
  2. To determine the impact of AID mutagenic activity on miRNA repertoire and its contribution to mature B cell transformation by promoting the escape from miRNA posttranscriptional gene expression regulation.


Publications


Contact

vgarciay@ucm.es

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Latest research

miR28-based combination therapy impairs aggressive B Cell Lymphoma growth by rewiring DNA replication

bioRxiV

 

microRNA fine-tuning of the germinal center response

Frontiers in Immunology (2021)

 

miRNA-based therapies in non-Hodgkin lymphoma: advances and future challenges

Review Trends Immunol (2020)


Current Funding

- Proyecto de investigación CONTRIBUCION FUNCIONAL DE LOS MICROARNS A LA TRANSFORMACION NEOPLASICA DE LINFOCITOS B (PID2019-107551RB-I00)