Intracellular signalling and cellular adhesion
RESEARCH INTERESTS
In recent years, there has been a significant amount of research focused on tumour exosomes (TEX) and their role in the progression of various types of cancer. These exosomes, which are found in high quantities in the tumour microenvironment (TEM), have been shown to induce changes in immune target cells, resulting in the development of an immunosuppressive phenotype. Specifically, they have been found to modulate the activity of neutrophils, influencing their anti-tumour profile and ability to induce pro-tumour NETs (neutrophil extracellular traps). Furthermore, immune cell exosomes (IEX) released into the TEM have been found to promote tumour progression. Our main focus is to understand the molecular mechanisms underlying the interaction between tumour and immune cell-derived exosomes and the cellular components of the TEM, with a particular emphasis on integrins as adhesion molecules. By studying the relationship between tumour exosomes and neutrophil activity, as well as investigating the formation of NETs, we hope to shed light on the mechanisms driving cancer progression and identify potential therapeutic targets.
We are part of :
GRUPO INVESTIGACION UCM Inmunobiología Linfocitaria (Ref 920631 ): Cellular immunology: Adhesión celular y señalización intracelular
GRUPO INVESTIGACION Inmunobiología Linfocitaria ( Ref IBL-6): Instituto de Investigación Hospital 12 de Octubre.
ÁREA 6: ENFERMEDADES INFLAMATORIAS Y TRASTORNOS INMUNITARIOS . Cellular immunology: Adhesión celular y señalización intracelular
Meet the People Lab
Lara Álvarez Rodríguez at PhDay CNIC
