Radicales libres
Proyectos y Publicaciones
PUBLICACIONES, ARTICULOS EN REVISTAS Y LIBROS CIENTIFICOS
CLAVE: A= artículo en revista científica; R = revisión invitada en revista científica; CL= capítulo de libro. L= libro completo.
1) S. Cadenas, C. Rojas and G. Barja. Endotoxin Increases Oxidative Injury to Proteins in the Guinea Pig Liver: Protection by Dietary Vitamin C. Pharmacology and Toxicology. Volumen 82, pág. 11-18 (1998). A
2) R. Pérez-Campo, M. López-Torres, S. Cadenas, C. Rojas and G. Barja. The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach. Journal of Comparative Physiology. Volumen 168B, pág. 149-158 (1998). R
3) G. Barja. El Problema del Envejecimiento. Akal, Madrid (1998). L
4) A. Herrero, S. Cadenas and G. Barja. Heart and non-synaptic brain mitochondrial H2O2 production does not increase in proportion to O2 consumption during the state 4 to state 3 transition. Main free radical generation at Complex I. Biothermokinetics in the Post Genomic Era. C. Larsson, I. Pahlman and L. Gustafsson. Chalmers, Göteborg (1998). pag. 370-374. CL
5) A. Herrero and G. Barja. H2O2 production of heart mitochondria and aging rate are slower in canaries and parakeets than in mice: sites of free radical generation and mechanisms involved. Mechanisms of Ageing and Development. Volumen 103, pág. 133-146 (1998). A
6) G. Barja and A. Herrero. Localization at Complex I and mechanism of the higher free radical production of brain non-synaptic mitochondria in the short-lived rat than in the longevous pigeon. Journal of Bioenergetics and Biomembranes. Volumen 30, pág. 235-243 (1998). A
7) G. Barja. Mitochondrial free radical production and aging in mammals and birds. Annals of the New York Academy of Sciences.Volumen 854, pág. 224-238 (1998). R
8) R. Pamplona, M. Portero-Otín, C. Ruiz, J. Prat, M.J. Bellmunt and Barja G. Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals. Journal of Lipid Research. Volumen 39, pág. 1989-1994 (1998). A
9) G. Barja. Kinetic Measurement of Mitochondrial Oxygen Radical Production (CAPITULO 23). Methods in Aging Research. B.P. Yu.CRC Press, Boca Ratón, USA (1999). Capítulo 23, pág. 533-548. CL
10) A. Guerrero, R. Pamplona, M. Portero-Otín, G. Barja and M. López-Torres. Effects of thyroid status on lipid composition and peroxidation in mice liver. Free Radical Biology and Medicine.Volumen 26, pág. 73-80 (1999). A
11) R. Pamplona, M. Portero-Otín, J.R. Requena, S.R. Thorpe, A. Herrero and G. Barja. A low degree of fatty acid unsaturation leads to lower lipid peroxidation and lipoxidation-derived protein modification in heart mitochondria of the longevous pigeon than in the short-lived rat. Mechanisms of Ageing and Development. Volumen 106, pág. 283-296 (1999). A
12) R. Pamplona, M. Portero-Otín, D. Riba, F. Ledo, R. Gredilla, A. Herrero, and G. Barja. Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse. Aging Clinical and Experimental Research. Volumen 11, pág. 44-49 (1999). A
13) S. Cadenas and G. Barja. Resveratrol, melatonin, vitamin E and PBN protect against renal oxidative DNA damage induced by the kidney carcinogen KBrO3. Free Radical Biology and Medicine. Volumen 26, pág. 1531-1537 (1999). A
14) G. Barja. Mitochondrial oxygen radical generation: sites of production in states 4 and 3, organ specificity and relationship with aging rate. Journal of Bioenergetics and Biomembranes.Volumen 31, pág. 347-366 (1999). R
15) AUTORES: R. Pamplona, M. Portero-Otín, D. Riba, C. Ruiz, M.J. Bellmunt, J.R. Requena, S. Thorpe, J.W. Baynes, M. Romero, M. López-Torres and G. Barja. Thyroid status modulates glycoxidative and lipoxidative modification of tissue proteins. Free Radical Biology and Medicine. Volumen 27, pág. 901-910 (1999). A
16) Fabre E., J. Monserrat, A. Herrero, G. Barja and M.L. Leret. Effect of MPTP on brain mitochondrial H2O2 and ATP production and on dopamine and DOPAC in the striatum. Journal of Physiology and Biochemistry. Volumen 55, pág. 325-332 (1999). A
17) A. Herrero and G. Barja. 8-oxodeoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging.Aging Clinical and Experimental Research. Volumen 11, pág. 294-300 (1999). A
18) R. Pamplona, M. Portero-Otín, C. Ruiz, R. Gredilla, A. Herrero and G. Barja. Double bond content of phospholipids and lipid peroxidation negatively correlate with maximum longevity in the heart of mammals. Mechanisms of Ageing and Development.Volumen 112, pág. 169-183 (1999). A
19) G. Barja and A. Herrero. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. FASEB Journal. Volumen 14, pág. 312-318 (2000). A
20) Pamplona R., Portero-Otín M., Riba D., Requena J.R., Thorpe S.R., López-Torres M., and Barja G. Low Fatty Acid Unsaturation: a Mechanism for Lowered Lipoperoxidative Modification of Tissue Proteins in Mammalian Species with Long Life Span. Journal of Gerontology. Volumen 55A, pág. B286-B291 (2000). A
21) G. Barja. The flux of free radical attack through mitochondrial DNA is related to aging rate. Aging Clinical and Experimental Research. Volumen 12, pág. 342-355 (2000). R
22) A. Herrero and G. Barja. Localization of the site of oxygen radical generation inside the Complex I of heart and non-synaptic brain mammalian mitochondria. Journal of Bioenergetics and Biomembranes. Volumen 32, pág. 609-615 (2000). R
23) M. López-Torres, M. Romero and G. Barja. Effect of thyroid hormones on mitochondrial oxygen free radical production and DNA oxidative damage in the rat heart. Molecular and Cellular Endocrinology. Volumen 168, pág. 127-134 (2000). A
24) G. Barja. Ubiquinone and Oxidative Stress: Antioxidant, and Possible Prooxidant Functions. Mitochondrial Ubiquinone (Coenzyme Q1O): Biochemical, Functional, Medical, and Therapeutic Aspects in Human Health and Diseases. Volumen 2.M. Ebadi, J. Marwah, and R. Chopra. Prominent Press, Scottsdale, Arizona, USA (2001). Capítulo 5, pag. 63-88. CL
25) Asunción Herrero, Manuel Portero-Otín, María Josep Bellmunt, Reinald Pamplona, and Gustavo Barja. Effect of the degree of fatty acid unsaturation of rat heart mitochondria on their rates of H2O2 production and lipid and protein oxidative damage. Mechanisms of Ageing and Development. Volumen: 122, pag. 427-443 (2001). A
26) R. Gredilla, A. Sanz, M. López-Torres and G. Barja. Caloric restriction decreases mitochondrial free radical generation at Complex I and lowers oxidative damage to mitochondrial DNA in the rat skeletal muscle. FASEB Journal. Volumen: 15, pág. 1589-1591 (2001). A
27) A. Herrero and G. Barja. Effect of aging on mitochondrial and nuclear DNA oxidative damage in the heart and brain throughout the life span of the rat. Journal of the American Aging Association (antes "AGE"). Volumen: 24, pag. 45-50 (2001). A
28) Ricardo Gredilla, Gustavo Barja and Mónica López-Torres. Thyroid hormone-induced oxidative damage on lipids, glutathione and DNA in the mouse heart. Free Radical Research. Volumen: 35, pág. 417-425 (2001). A 29) R. Gredilla, M. López Torres, M. Portero-Otín, R. Pamplona and G. Barja. Influence of hyper- and hypothyroidism on lipid peroxidation, unsaturation of phospholipids, glutathione system and oxidative damage to nuclear and mitochondrial DNA in mice skeletal muscle. Molecular and Cellular Biochemistry. Volumen: 221, pag. 41-48 (2001). A
30) R. Gredilla, G. Barja and M. López-Torres. Effect of short-term caloric restriction on H2O2 production and oxidative DNA damage in rat liver mitochondria, and location of the free radical source. Journal of Bioenergetics and Biomembranes.Volumen: 33, pág. 279-287, 2001. A
31) M. Portero-Otín, Bellmunt M.J., Ruiz M.C., Barja G. and Pamplona R. Correlation of fatty acid unsaturation of the major liver mitochondrial phospholipid classes in mammals to their maximum life span potential. Lipids. Volumen: 36, pág. 491-498 (2001). A
32) R. Pamplona, M. Portero-Otín, M.J. Bellmunt, R. Gredilla and G. Barja. Aging increases Nepsilon-(Carboxymethyl)lysine and caloric restriction decreases Nepsilon-(Carboxyethyl)lysine and Nepsilon-(Malondialdehyde)lysine in rat heart mitochondrial proteins. Free Radical Research. Volumen: 36, pág. 47-54, (2002). A
33) M.L. Leret, J.A. San Millán, E. Fabre, R. Gredilla and G. Barja. Deprenyl protects from MPTP-induced Parkinson-like syndrome and glutathione oxidation in rat striatum. Toxicology. Volumen: 170, pág. 165-171 (2002). A
34) M. López-Torres, R. Gredilla, A. Sanz and G. Barja. Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria. Free Radical Biology and Medicine. Volumen: 32, pág. 882-889 (2002). A
35) G. Barja. The quantitative measurement of H2O2 generation in isolated mitochondria. Journal of Bioenergetics and Biomembranes. Volumen: 34, pág. 227-233 (2002). A
36) R. Pamplona, G. Barja and M. Portero-Otín. Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation. Annals of the New York Academy of Sciences. Volumen: 959, pág. 475-490 (2002). R
37) G. Barja. Endogenous oxidative stress: relationship to aging, longevity and caloric restriction. Aging Research Reviews. Volumen: 1, pág. 397-411 (2002). R
38) G. Barja. Rate of generation of oxidative stress-related damage and animal longevity. Free Radical Biology and Medicine.Volumen: 33, pág. 1167-1172 (2002). R
39) Gredilla R., López-Torres M. and G. Barja. Effect of time of restriction on the decrease in mitochondrial H2O2 production and oxidative DNA damage in the heart of food restricted rats. Microscopy Research and Technique. Volumen: 59, pág. 273-277 (2002). A
40) R. Pamplona, M. Portero-Otín, J. Requena, R. Gredilla and G. Barja. Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after four months of caloric restriction than in age-matched controls. Mechanisms of Ageing and Development. Volumen: 123, pág. 1437-1446 (2002). A
41) B. Drew, S. Phaneuf, A. Dirks, C. Selman, R. Gredilla, A. Lezza, G. Barja, and C. Leeuwenburgh. Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart. American Journal of Physiology.Volumen: 284, pág. R474-R480 (2003) A
42) A. Sanz, A. Bartke and G. Barja. Long-lived Ames dwarf mice: oxidative damage to mitochondrial DNA in heart and brain. Journal of the American Aging Association (antes "AGE").Volumen: 25, pág. 119-122, (2002)ojo A
PROYECTOS DE INVESTIGACION SUBVENCIONADOS
(últimos 5 años)
1) "Diagnóstico precoz en humanos en el Parkinson e inducción por MPTP: complejo I mitocondrial y daño oxidativo al ADN, proteínas y lípidos". ENTIDAD FINANCIADORA: Universidad Complutense de Madrid no PR/98-7754. DURACION: 1,25 años, DESDE: 1-10-1998 HASTA: 30-12-1999. INVESTIGADOR PRINCIPAL: Gustavo Barja de Quiroga. CANTIDAD CONCEDIDA: 1.300.000 pts.
2) "Radicales libres y envejecimiento: mitocondrias, daño oxidativo al ADN, ácidos grasos y restricción calórica". ENTIDAD FINANCIADORA: FIS no 99/1049. DURACION: 3 años, DESDE: 1-1-1999 HASTA : 30-12-2001. INVESTIGADOR PRINCIPAL: Gustavo Barja de Quiroga. CANTIDAD CONCEDIDA: 7.560.000 pts.
3) "Molecular mechanisms of oxidative stress in aging muscle". ENTIDAD FINANCIADORA: National Institutes of Health (NIH)-National Institute of Aging (NIA) de USA no RO1AG17994-01. DURACION: 5 años, DESDE: 2001 HASTA: 2005. INVESTIGADOR PRINCIPAL: Christian Leeuwenburgh, Univ. de Florida, USA. CANTIDAD CONCEDIDA: 1.000.000 US$
4) "Mecanismo de acción de la restricción calórica sobre el estrés oxidativo mitocondrial y la velocidad del envejecimiento".ENTIDAD FINANCIADORA: Ministerio de Ciencia y Tecnología (Proyectos I+D, convocatoria: BOE 15 de enero de 2002). no SAF2002-01635. DURACION DESDE: 2003 HASTA : 2006. INVESTIGADOR PRINCIPAL: Gustavo Barja de Quiroga. CANTIDAD CONCEDIDA: 69.000 Euros.