Departamentos

SELECTED PUBLICATIONS (2009-2019)

 

Herrero R, Prados L, Ferruelo A, Puig F, Pandolfi R, Guillamat-Prats R, Moreno L, Matute-Bello G, Artigas A, Esteban A, Lorente JÁ. Fas activation alters tight junction proteins in acute lung injury. Thorax. 2019 Jan;74(1):69-82.

 

Morales-Cano D, Callejo M, Barreira B, Mondejar-Parreño G, Esquivel-Ruiz S, Ramos S, Martín MÁ, Cogolludo A, Moreno L, Perez-Vizcaino F. Elevated pulmonary arterial pressure in Zucker diabetic fatty rats. PLoS One. 2019 Jan 28;14(1):e0211281

 

Cogolludo A, Villamor E, Perez-Vizcaino F, Moreno L. Ceramide and Regulation of Vascular Tone. Int J Mol Sci. 2019 Jan 18;20(2). pii: E411.

 

Mondejar-Parreño G, Callejo M, Barreira B, Morales-Cano D, Esquivel-Ruiz S, Moreno L, Cogolludo A, Perez-Vizcaino F. miR-1 is increased in pulmonary hypertension and downregulates Kv1.5 channels in rat pulmonary arteries.J Physiol. 2019 Feb;597(4):1185-1197. 

 

Cunningham KP, Holden RG, Escribano-Subias PM, Cogolludo A, Veale EL, Mathie A. Characterization and regulation of wild-type and mutant TASK-1 two pore domain potassium channels indicated in pulmonary arterial hypertension.J Physiol. 2019 Feb;597(4):1087-1101.

 

Alvarez-Fuente M, Moreno L, Lopez-Ortego P, Arruza L, Avila-Alvarez A, Muro M, Gutierrez E, Zozaya C, Sanchez-Helguera G, Elorza D, Martinez-Ramas A, Villar G, Labrandero C, Martinez L, Casado T, Cuadrado I, Del Cerro MJ. Exploring clinical, echocardiographic and molecular biomarkers to predict bronchopulmonary dysplasia. PLoS One. 2019 Mar 6;14(3):e0213210.

 

Mondéjar-Parreño G, Moral-Sanz J, Barreira B, De la Cruz A, Gonzalez T, Callejo M, Esquivel-Ruiz S, Morales-Cano D, Moreno L, Valenzuela C, Perez-Vizcaino F, Cogolludo A. Activation of Kv 7 channels as a novel mechanism for NO/cGMP-induced pulmonary vasodilation.Br J Pharmacol. 2019 Jul;176(13):2131-2145.

 

Mondejar-Parreño G, Callejo M, Barreira B, Morales-Cano D, Esquivel-Ruiz S, Filice M, Moreno L, Cogolludo A, Perez-Vizcaino F. miR-1 induces endothelial dysfunction in rat pulmonary arteries. J Physiol Biochem. 2019 Aug 20.

 

Kumar R, Mickael C, Kassa B, Sanders L, Koyanagi D, Hernandez-Saavedra D, Freeman S, Morales-Cano D, Cogolludo A, McKee AS, Fontenot AP, Butrous G, Tuder RM, Graham BB. Th2 CD4+ T Cells Are Necessary and Sufficient for Schistosoma-Pulmonary Hypertension. J Am Heart Assoc. 2019 Aug 6;8(15):e013111.

 

Álvarez-Cilleros D, López-Oliva ME, Morales-Cano D, Barreira B, Pérez-Vizcaíno F, Goya L, Ramos S, Martín MÁ. Dietary Cocoa Prevents Aortic Remodeling and Vascular Oxidative Stress in Diabetic Rats. Mol Nutr Food Res. 2019 Sep;63(18):e1900044. 

 

González-Tajuelo R, de la Fuente-Fernández M, Morales-Cano D, Muñoz-Callejas A, González-Sánchez E, Silván J, Serrador JM, Cadenas S, Barreira B, Espartero-Santos M, Gamallo C, Vicente-Rabaneda EF, Castañeda S, Pérez-Vizcaíno F, Cogolludo Á, Jiménez-Borreguero LJ, Urzainqui A. PSGL1-deficient mice develop spontaneous pulmonary hypertension associated to systemic sclerosis. Arthritis Rheumatol. 2019 Sep 11.

 

Villamor E, Moreno L, Mohammed R, Pérez-Vizcaíno F, Cogolludo A. Reactive oxygen species as mediators of oxygen signaling during fetal-to-neonatal circulatory transition. Free Radic Biol Med. 2019 Oct;142:82-96.

 

Chamorro V, Morales-Cano D, Milara J, Barreira B, Moreno L, Callejo M, Mondejar-Parreño G, Esquivel-Ruiz S, Cortijo J, Cogolludo Á, Barberá JA, Perez-Vizcaino F. Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching. PLoS One. 2018 Jan 24;13(1):e0191239

 

Toral M, Romero M, Rodríguez-Nogales A, Jiménez R, Robles-Vera I, Algieri F, Chueca-Porcuna N, Sánchez M, de la Visitación N, Olivares M, García F, Pérez-Vizcaíno F, Gálvez J, Duarte J. Lactobacillus fermentum Improves Tacrolimus-Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling. Mol Nutr Food Res. 2018 May 30:e1800033. 

 

Perez-Vizcaino F, Fraga CG.  Research trends in flavonoids and health. Arch Biochem Biophys. 2018 May 15;646:107-112

 

Milara J, Ballester B, Morell A, Ortiz JL, Escrivá J, Fernández E, Perez-Vizcaino F, Cogolludo A, Pastor E, Artigues E, Morcillo E, Cortijo J. JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study.Thorax. 2018 Jun;73(6):519-529. 

 

Callejo M, Mondejar-Parreño G, Barreira B, Izquierdo-Garcia JL, Morales-Cano D, Esquivel-Ruiz S, Moreno L, Cogolludo Á, Duarte J, Perez-Vizcaino F. Pulmonary Arterial Hypertension Affects the Rat Gut Microbiome.

Sci Rep. 2018 Jun 26;8(1):9681.

 

Mondejar-Parreño G, Morales-Cano D, Barreira B, Callejo M, Ruiz-Cabello J, Moreno L, Esquivel-Ruiz S, Mathie A, Butrous G, Perez-Vizcaino F, Cogolludo A. HIV transgene expression impairs K+ channel function in the pulmonary vasculature. Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L711-L723.

 

Milara J, Díaz-Platas L, Contreras S, Ribera P, Roger I, Ballester B, Montero P, Cogolludo Á, Morcillo E, Cortijo J. MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease. Respir Res. 2018 Nov 20;19(1):226. 

 

Sanchez M, Romero M, Gómez-Guzman M, Tamargo J, Pérez-Vizcaino F, Duarte J. Cardiovascular effects of flavonoids. Curr Med Chem. 2018 Dec 19

 

Royo F, Moreno L, Mleczko J, Palomo L, Gonzalez E, Cabrera D, Cogolludo A, Vizcaino FP, van-Liempd S, Falcon-Perez JM. Hepatocyte-secreted extracellular vesicles modify blood metabolome and endothelial function by an arginase-dependent mechanismSci Rep. 2017 Feb 17;7:42798

 

Toral M, Romero M, Pérez-Vizcaíno F, Duarte J, Jiménez R. Antihypertensive effects of peroxisome proliferator-activated receptor-β/δ activation.Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H189-H200

 

Robles-Vera I, Toral M, Romero M, Jiménez R, Sánchez M, Pérez-Vizcaíno F, Duarte J. Antihypertensive Effects of Probiotics.Curr Hypertens Rep. 2017 Apr;19(4):26.

 

Romero M, Toral M, Robles-Vera I, Sánchez M, Jiménez R, O'Valle F, Rodriguez-Nogales A, Pérez-Vizcaino F, Gálvez J, Duarte J. Activation of Peroxisome Proliferator Activator Receptor β/δ Improves Endothelial Dysfunction and Protects Kidney in Murine Lupus. Hypertension. 2017 Apr;69(4):641-650.

 

Pandolfi R, Barreira B, Moreno E, Lara-Acedo V, Morales-Cano D, Martínez-Ramas A, de Olaiz Navarro B, Herrero R, Lorente JÁ, Cogolludo Á, Pérez-Vizcaíno F, Moreno L. Role of acid sphingomyelinase and IL-6 as mediators of endotoxin-induced pulmonary vascular dysfunction. Thorax. 2017 May;72(5):460-471. 

 

Gonzalez-Obeso E, Docio I, Olea E, Cogolludo A, Obeso A, Rocher A, Gomez-Niño A. Guinea Pig Oxygen-Sensing and Carotid Body Functional Properties. Front Physiol. 2017 May 8;8:285

 

Romero M, Vera B, Galisteo M, Toral M, Gálvez J, Perez-Vizcaino F, Duarte J. Protective vascular effects of quercitrin in acute TNBS-colitis in rats: the role of nitric oxide. Food Funct. 2017 Aug 1;8(8):2702-2711.

 

Climent B, Sánchez A, Moreno L, Pérez-Vizcaíno F, García-Sacristán A, Rivera L, Prieto D. Underlying mechanisms preserving coronary basal tone and NO-mediated relaxation in obesity: Involvement of β1 subunit-mediated upregulation of BKCa channels. Atherosclerosis. 2017 Aug;263:227-236.

Mohammed R, Salinas CE, Giussani DA, Blanco CE, Cogolludo AL, Villamor E. Acute hypoxia-reoxygenation and vascular oxygen sensing in the chicken embryo. Physiol Rep. 2017 Nov;5(22). 

 

Labrousse-Arias D, Castillo-González R, Rogers NM, Torres-Capelli M, Barreira B, Aragonés J, Cogolludo Á, Isenberg JS, Calzada MJ. HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction. Cardiovasc Res. 2016 Jan 1;109(1):115-30.

 

Toral M, Romero M, Jiménez R, Robles-Vera I, Tamargo J, Martínez MC, Pérez-Vizcaíno F, Duarte J. Role of UCP2 in the protective effects of PPARβ/δ activation on lipopolysaccharide-induced endothelial dysfunction. Biochem Pharmacol. 2016 Jun 15;110-111:25-36.

 

Romero M, Jiménez R, Toral M, León-Gómez E, Gómez-Gúzman M, Sánchez M, Zarzuelo MJ, Rodríguez-Gómez I, Rath G, Tamargo J, Pérez-Vizcaíno F, Dessy C, Duarte J. Vascular and Central Activation of Peroxisome Proliferator-Activated Receptor-β Attenuates Angiotensin II-Induced Hypertension: Role of RGS-5. J Pharmacol Exp Ther. 2016 Jul;358(1):151-63.

 

Morales-Cano D, Moreno L, Barreira B, Briones AM, Pandolfi R, Moral-Sanz J, Callejo M, Mondejar-Parreño G, Cortijo J, Salaices M, Duarte J, Perez-Vizcaino F, Cogolludo A. Activation of PPARβ/δ prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries. Clin Sci (Lond). 2016 Oct 1;130(20):1823-36

 

Brinks L, Moonen RM, Moral-Sanz J, Barreira B, Kessels L, Perez-Vizcaino F, Cogolludo A, Villamor E. Hypoxia-induced contraction of chicken embryo mesenteric arteries: mechanisms and developmental changes. Am J Physiol Regul Integr Comp Physiol. 2016 Nov

 

Chamorro V, Pandolfi R, Moreno L, Barreira B, Martínez-Ramas A, Morales-Cano D, Ruiz-Cabello J, Lorente JA, Duarte J, Cogolludo Á, Alvarez-Sala JL, Perez-Vizcaino F. Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion Molecules. 2016 Dec 20;21(12).

 

Jimenez R, Lopez-Sepulveda R, Romero M, Toral M, Cogolludo A, Perez-Vizcaino F, Duarte J. Quercetin and its metabolites inhibit the membrane NADPH oxidase activity in vascular smooth muscle cells from normotensive and spontaneously hypertensive rats. Food Funct. 2015 Feb;6(2):409-14.

 

Morales-Cano D, Moreno L, Barreira B, Pandolfi R, Chamorro V, Jimenez R, Villamor E, Duarte J, Perez-Vizcaino F, Cogolludo A. Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia. Cardiovasc Res. 2015 Apr 1;106(1):98-108

 

Prieto-Lloret J, Ramirez M, Olea E, Moral-Sanz J, Cogolludo A, Castañeda J, Yubero S, Agapito T, Gomez-Niño A, Rocher A, Rigual R, Obeso A, Perez-Vizcaino F, González C. Hypoxic pulmonary vasoconstriction, carotid body function and erythropoietin production in adult rats perinatally exposed to hyperoxia.J Physiol. 2015 Jun 1;593(11):2459-77.

 

Toral M, Gómez-Guzmán M, Jiménez R, Romero M, Zarzuelo MJ, Utrilla MP, Hermenegildo C, Cogolludo Á, Pérez-Vizcaíno F, Gálvez J, Duarte J. Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity. J Hypertens. 2015 Sep;33(9):1831-44.

 

Toral M, Romero M, Jiménez R, Mahmoud AM, Barroso E, Gómez-Guzmán M, Sánchez M, Cogolludo Á, García-Redondo AB, Briones AM, Vázquez-Carrera M, Pérez-Vizcaíno F, Duarte J. Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction. Clin Sci (Lond). 2015 Nov;129(9):823-37.

 

Moreno L, Moral-Sanz J, Morales-Cano D, Barreira B, Moreno E, Ferrarini A, Pandolfi R, Ruperez FJ, Cortijo J, Sanchez-Luna M, Villamor E, Perez-Vizcaino F, Cogolludo A. Ceramide mediates acute oxygen sensing in vascular tissues. Antioxid Redox Signal. 2014 Jan 1;20(1):1-14.

 

van der Sterren S, Kessels L, Perez-Vizcaino F, Cogolludo AL, Villamor E. Prenatal exposure to hyperoxia modifies the thromboxane prostanoid receptor-mediated response to H2O2 in the ductus arteriosus of the chicken embryo. J Physiol Pharmacol. 2014 Apr;65(2):283-93.

 

Moral-Sanz J, Moreno L, Cogolludo A, Perez-Vizcaino F. Pulmonary vascular function in insulin resistance and diabetes. Curr Vasc Pharmacol. 2014 May;12(3):473-82.

 

Quintela AM, Jiménez R, Piqueras L, Gómez-Guzmán M, Haro J, Zarzuelo MJ, Cogolludo A, Sanz MJ, Toral M, Romero M, Pérez-Vizcaíno F, Duarte J. PPARβ activation restores the high glucose-induced impairment of insulin signalling in endothelial cells. Br J Pharmacol. 2014 Jun;171(12):3089-102.

 

Oliveras A, Roura-Ferrer M, Solé L, de la Cruz A, Prieto A, Etxebarria A, Manils J, Morales-Cano D, Condom E, Soler C, Cogolludo A, Valenzuela C, Villarroel A, Comes N, Felipe A. Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology. Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1522-30.

 

Duarte J, Francisco V, Perez-Vizcaino F. Modulation of nitric oxide by flavonoids. Food Funct. 2014 Aug;5(8):1653-68.

 

Gómez-Guzmán M, Jiménez R, Romero M, Sánchez M, Zarzuelo MJ, Gómez-Morales M, O'Valle F, López-Farré AJ, Algieri F, Gálvez J, Pérez-Vizcaino F, Sabio JM, Duarte J. Chronic hydroxychloroquine improves endothelial dysfunction and protects kidney in a mouse model of systemic lupus erythematosus. Hypertension. 2014 Aug;64(2):330-7.

 

Climent B, Moreno L, Martínez P, Contreras C, Sánchez A, Pérez-Vizcaíno F, García-Sacristán A, Rivera L, Prieto D. Upregulation of SK3 and IK1 channels contributes to the enhanced endothelial calcium signaling and the preserved coronary relaxation in obese Zucker rats.PLoS One. 2014 Oct 10;9(10):e109432.

 

Perez A, Gonzalez-Manzano S, Jimenez R, Perez-Abud R, Haro JM, Osuna A, Santos-Buelga C, Duarte J, Perez-Vizcaino F. The flavonoid quercetin induces acute vasodilator effects in healthy volunteers: correlation with beta-glucuronidase activity. Pharmacol Res. 2014 Nov;89:11-8.

 

Morales-Cano D, Menendez C, Moreno E, Moral-Sanz J, Barreira B, Galindo P, Pandolfi R, Jimenez R, Moreno L, Cogolludo A, Duarte J, Perez-Vizcaino F. The flavonoid quercetin reverses pulmonary hypertension in rats. PLoS One. 2014 Dec 2;9(12):e114492.

 

Zarzuelo MJ, López-Sepúlveda R, Sánchez M, Romero M, Gómez-Guzmán M, Ungvary Z, Pérez-Vizcaíno F, Jiménez R, Duarte J. SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging. Biochem Pharmacol. 2013 May 1;85(9):1288-96.

 

Menendez C, Martinez-Caro L, Moreno L, Nin N, Moral-Sanz J, Morales D, Cogolludo A, Esteban A, Lorente JA, Perez-Vizcaino F. Pulmonary vascular dysfunction induced by high tidal volume mechanical ventilation. Crit Care Med. 2013 Aug;41(8):e149-55.

 

Reboredo M, Chang HC, Barbero R, Rodríguez-Ortigosa CM, Pérez-Vizcaíno F, Morán A, García M, Banales JM, Carreño N, Alegre F, Herrero I, Quiroga J, Prieto J, Sangro B. Zolmitriptan: a novel portal hypotensive agent which synergizes with propranolol in lowering portal pressure.PLoS One. 2013;8(1):e52683.

 

Peñuelas O, Melo E, Sánchez C, Sánchez I, Quinn K, Ferruelo A, Pérez-Vizcaíno F, Esteban A, Navajas D, Nin N, Lorente JA, Farré R. Antioxidant effect of human adult adipose-derived stromal stem cells in alveolar epithelial cells undergoing stretch. Respir Physiol Neurobiol. 2013 Aug 1;188(1):1-8.

 

Menendez C, Martinez-Caro L, Moreno L, Nin N, Moral-Sanz J, Morales D, Cogolludo A, Esteban A, Lorente JA, Perez-Vizcaino F. Pulmonary vascular dysfunction induced by high tidal volume mechanical ventilation. Crit Care Med. 2013 Aug;41(8):e149-55.

 

Zarzuelo MJ, Gómez-Guzmán M, Jiménez R, Quintela AM, Romero M, Sánchez M, Zarzuelo A, Tamargo J, Pérez-Vizcaíno F, Duarte J. Effects of peroxisome proliferator-activated receptor-β activation in endothelin-dependent hypertension. Cardiovasc Res. 2013 Sep 1;99(4):622-31

 

Bailey L, Moreno L, Manigold T, Krasniqi S, Kropshofer H, Hinton H, Singer T, Suter L, Hansel TT, Mitchell JA. A simple whole blood bioassay detects cytokine responses to anti-CD28(SA) and anti-CD52 antibodies. J Pharmacol Toxicol Methods. 2013 Sep-Oct;68(2):231-239.

 

Almudéver P, Milara J, De Diego A, Serrano-Mollar A, Xaubet A, Perez-Vizcaino F, Cogolludo A, Cortijo J. Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis. Thorax. 2013 Oct;68(10):938-48. 

 

Moreno L, Gatheral T. Therapeutic targeting of NOD1 receptors. Br J Pharmacol. 2013 Oct;170(3):475-85.

 

Zarzuelo MJ, Gómez-Guzmán M, Jiménez R, Quintela AM, Romero M, Sánchez M, Zarzuelo A, Tamargo J, Pérez-Vizcaíno F, Duarte J. Effects of peroxisome proliferator-activated receptor-β activation in endothelin-dependent hypertension. Cardiovasc Res. 2013 Sep 1;99(4):622-31.

 

Almudéver P, Milara J, De Diego A, Serrano-Mollar A, Xaubet A, Perez-Vizcaino F, Cogolludo A, Cortijo J. Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis. Thorax. 2013 Oct;68(10):938-48.

 

Moreno L, Moral-Sanz J, Morales-Cano D, Barreira B, Moreno E, Ferrarini A, Pandolfi R, Ruperez FJ, Cortijo J, Sanchez-Luna M, Villamor E, Perez-Vizcaino F,  Cogolludo A. Ceramide Mediates Acute Oxygen Sensing in Vascular Tissues. Antioxid Redox Signal. 2013 Aug 21. [Epub ahead of print] PubMed PMID: 23725018.

 

Peñuelas O, Melo E, Sánchez C, Sánchez I, Quinn K, Ferruelo A, Pérez-Vizcaíno  F, Esteban A, Navajas D, Nin N, Lorente JA, Farré R. Antioxidant effect of human  adult adipose-derived stromal stem cells in alveolar epithelial cells undergoing  stretch. Respir Physiol Neurobiol. 2013 Aug 1;188(1):1-8.

 

Menendez C, Martinez-Caro L, Moreno L, Nin N, Moral-Sanz J, Morales D, Cogolludo A, Esteban A, Lorente JA, Perez-Vizcaino F. Pulmonary vascular dysfunction induced by high tidal volume mechanical ventilation. Crit Care Med. 2013 Aug;41(8):e149-55.

 

Zarzuelo MJ, López-Sepúlveda R, Sánchez M, Romero M, Gómez-Guzmán M, Ungvary Z, Pérez-Vizcaíno F, Jiménez R, Duarte J. SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging. Biochem Pharmacol. 2013 May 1;85(9):1288-96.

 

Reboredo M, Chang HC, Barbero R, Rodríguez-Ortigosa CM, Pérez-Vizcaíno F, Morán A, García M, Banales JM, Carreño N, Alegre F, Herrero I, Quiroga J, Prieto  J, Sangro B.  Zolmitriptan: a novel portal hypotensive agent which synergizes with propranolol in lowering portal pressure. PLoS One. 2013;8(1):e52683. doi: 10.1371/journal.pone.0052683.

 

Quintela AM, Jiménez R, Gómez-Guzmán M, Zarzuelo MJ, Galindo P, Sánchez M, Vargas F, Cogolludo A, Tamargo J, Pérez-Vizcaíno F, Duarte J. Activation of peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) prevents endothelial dysfunction in type 1 diabetic rats. Free Radic Biol Med. 2012 Aug 15;53(4):730-41.

 

Perez-Vizcaino F, Duarte J, Santos-Buelga C. The flavonoid paradox: conjugation and deconjugation as key steps for the biological activity of flavonoids. J Sci Food Agric. 2012 Jul;92(9):1822-5.

 

Galindo P, González-Manzano S, Zarzuelo MJ, Gómez-Guzmán M, Quintela AM, González-Paramás A, Santos-Buelga C, Pérez-Vizcaíno F, Duarte J, Jiménez R. Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats. Food Funct. 2012 Jun;3(6):643-50.

 

Jiménez R, Duarte J, Perez-Vizcaino F. Epicatechin: endothelial function and  blood pressure. J Agric Food Chem. 2012 Sep 12;60(36):8823-30.

 

Galindo P, Rodriguez-Gómez I, González-Manzano S, Dueñas M, Jiménez R, Menéndez C, Vargas F, Tamargo J, Santos-Buelga C, Pérez-Vizcaíno F, Duarte J. Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation. PLoS One. 2012;7(3):e32673.

 

Moral-Sanz J, Lopez-Lopez JG, Menendez C, Moreno E, Barreira B, Morales-Cano  D, Escolano L, Fernandez-Segoviano P, Villamor E, Cogolludo A, Perez-Vizcaino F,  Moreno L. Different patterns of pulmonary vascular disease induced by type 1 diabetes and moderate hypoxia in rats. Exp Physiol. 2012 May;97(5):676-86.

 

Menendez C, Dueñas M, Galindo P, González-Manzano S, Jimenez R, Moreno L, Zarzuelo MJ, Rodríguez-Gómez I, Duarte J, Santos-Buelga C, Perez-Vizcaino F. Vascular deconjugation of quercetin glucuronide: the flavonoid paradox revealed? Mol Nutr Food Res. 2011 Dec;55(12):1780-90.

 

Gómez-Guzmán M, Jiménez R, Sánchez M, Zarzuelo MJ, Galindo P, Quintela AM, López-Sepúlveda R, Romero M, Tamargo J, Vargas F, Pérez-Vizcaíno F, Duarte J. Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension. Free Radic Biol Med. 2012 Jan 1;52(1):70-9.

 

Gómez-Guzmán M, Jiménez R, Sánchez M, Romero M, O'Valle F, Lopez-Sepulveda R, Quintela AM, Galindo P, Zarzuelo MJ, Bailón E, Delpón E, Perez-Vizcaino F, Duarte J. Chronic (-)-epicatechin improves vascular oxidative and inflammatory status but not hypertension in chronic nitric oxide-deficient rats. Br J Nutr. 2011 Nov;106(9):1337-48.

 

Zarzuelo MJ, Jiménez R, Galindo P, Sánchez M, Nieto A, Romero M, Quintela AM, López-Sepúlveda R, Gómez-Guzmán M, Bailón E, Rodríguez-Gómez I, Zarzuelo A, Gálvez J, Tamargo J, Pérez-Vizcaíno F, Duarte J. Antihypertensive effects of peroxisome proliferator-activated receptor-β activation in spontaneously hypertensive rats. Hypertension. 2011 Oct;58(4):733-43.

 

Frazziano G, Moreno L, Moral-Sanz J, Menendez C, Escolano L, Gonzalez C, Villamor E, Alvarez-Sala JL, Cogolludo AL, Perez-Vizcaino F. Neutral sphingomyelinase, NADPH oxidase and reactive oxygen species. Role in acute hypoxic pulmonary vasoconstriction. J Cell Physiol. 2011 Oct;226(10):2633-40.

 

Lopez-Lopez JG, Moral-Sanz J, Frazziano G, Gomez-Villalobos MJ, Moreno L, Menendez C, Flores-Hernandez J, Lorente JA, Cogolludo A, Perez-Vizcaino F. Type 1 diabetes-induced hyper-responsiveness to 5-hydroxytryptamine in rat pulmonary arteries via oxidative stress and induction of cyclooxygenase-2. J Pharmacol Exp  Ther. 2011 Jul;338(1):400-7.

 

Gonzalez-Martín MC, Vega-Agapito MV, Conde SV, Castañeda J, Bustamante R, Olea E, Perez-Vizcaino F, Gonzalez C, Obeso A. Carotid body function and ventilatory responses in intermittent hypoxia. Evidence for anomalous brainstem integration of arterial chemoreceptor input. J Cell Physiol. 2011 Aug;226(8):1961-9.

 

Moral-Sanz J, Menendez C, Moreno L, Moreno E, Cogolludo A, Perez-Vizcaino F.   Pulmonary arterial dysfunction in insulin resistant obese Zucker rats. Respir Res. 2011 Apr 22;12:51. doi: 10.1186/1465-9921-12-51.

 

Moral-Sanz J, Gonzalez T, Menendez C, David M, Moreno L, Macias A, Cortijo J, Valenzuela C, Perez-Vizcaino F, Cogolludo A. Ceramide inhibits Kv currents and contributes to TP-receptor-induced vasoconstriction in rat and human pulmonary arteries. Am J Physiol Cell Physiol. 2011 Jul;301(1):C186-94.

 

Blanco-Rivero J, Márquez-Rodas I, Sastre E, Cogolludo A, Pérez-Vizcaíno F, del Campo L, Nava MP, Balfagón G. Cirrhosis decreases vasoconstrictor response to electrical field stimulation in rat mesenteric artery: role of calcitonin gene-related peptide. Exp Physiol. 2011 Mar;96(3):275-86.

 

Menendez C, Jimenez R, Moreno L, Galindo P, Cogolludo A, Duarte J, Perez-Vizcaino F. Lack of synergistic interaction between quercetin and catechin in systemic and pulmonary vascular smooth muscle. Br J Nutr. 2011 May;105(9):1287-93.

 

López-Sepúlveda R, Gómez-Guzmán M, Zarzuelo MJ, Romero M, Sánchez M, Quintela AM, Galindo P, O'Valle F, Tamargo J, Pérez-Vizcaíno F, Duarte J, Jiménez R. Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase. Clin Sci (Lond). 2011 Apr;120(8):321-33.

 

Macías A, Moreno C, Moral-Sanz J, Cogolludo A, David M, Alemanni M, Pérez-Vizcaíno F, Zaza A, Valenzuela C, González T. Celecoxib blocks cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) channels: effects on cardiac action potentials. J  Mol Cell Cardiol. 2010 Dec;49(6):984-92.

 

Perez-Vizcaino F, Duarte J. Flavonols and cardiovascular disease. Mol Aspects Med. 2010 Dec;31(6):478-94.

 

Perez-Vizcaino F, Cogolludo A, Moreno L. Reactive oxygen species signaling in pulmonary vascular smooth muscle. Respir Physiol Neurobiol. 2010 Dec 31;174(3):212-20.

 

Romero M, Jiménez R, Sánchez M, López-Sepúlveda R, Zarzuelo A, Tamargo J, Pérez-Vizcaíno F, Duarte J. Vascular superoxide production by endothelin-1 requires Src non-receptor protein tyrosine kinase and MAPK activation. Atherosclerosis. 2010 Sep;212(1):78-85.

 

Cogolludo A, Perez-Vizcaino F. 5-HT receptors and K(V) channel internalization. Adv Exp Med Biol. 2010;661:391-401.

 

Zoer B, Cogolludo AL, Perez-Vizcaino F, De Mey JG, Blanco CE, Villamor E. Hypoxia sensing in the fetal chicken femoral artery is mediated by the mitochondrial electron transport chain. Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R1026-34.

 

Gonzalez-Luis G, Perez-Vizcaino F, Blanco CE, Villamor E. Age-related changes in isoprostane-mediated relaxation of piglet blood vessels. Front Biosci (Elite Ed). 2010 Jan 1;2:369-79.

 

Moonen RM, Agren P, Cogolludo AL, Perez Vizcaino F, Villamor E. Response of chicken ductus arteriosus to hypercarbic and normocarbic acidosis. Neonatology. 2010 Jun;98(1):47-56. doi: 10.1159/000264735.

 

García-Septien J, Lorente JA, Delgado MA, de Paula M, Nin N, Moscoso A, Sánchez-Ferrer A, Perez-Vizcaino F, Esteban A. Levosimendan increases portal blood flow and attenuates intestinal intramucosal acidosis in experimental septic shock. Shock. 2010 Sep;34(3):275-80.

 

Jiménez R, Sánchez M, Zarzuelo MJ, Romero M, Quintela AM, López-Sepúlveda R,  Galindo P, Gómez-Guzmán M, Haro JM, Zarzuelo A, Pérez-Vizcaíno F, Duarte J. Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway. J Pharmacol Exp Ther. 2010 Feb;332(2):554-61. 36: Romero M, Jiménez R, Hurtado B, Moreno JM, Rodríguez-Gómez I, López-Sepúlveda R, Zarzuelo A, Pérez-Vizcaino F, Tamargo J, Vargas F, Duarte J. Lack of beneficial metabolic effects of quercetin in adult spontaneously hypertensive rats. Eur J Pharmacol. 2010 Feb 10;627(1-3):242-50.

 

Belik J, González-Luis GE, Perez-Vizcaino F, Villamor E. Isoprostanes in fetal and neonatal health and disease. Free Radic Biol Med. 2010 Jan 15;48(2):177-88.

 

Cogolludo AL, Moral-Sanz J, van der Sterren S, Frazziano G, van Cleef AN, Menéndez C, Zoer B, Moreno E, Roman A, Pérez-Vizcaino F, Villamor E. Maturation of O2 sensing and signaling in the chicken ductus arteriosus. Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L619-30.

 

Perez-Vizcaino F, Duarte J, Jimenez R, Santos-Buelga C, Osuna A. Antihypertensive effects of the flavonoid quercetin. Pharmacol Rep. 2009 Jan-Feb;61(1):67-75. Review. PubMed PMID: 19307694.

 

Briones AM, Padilha AS, Cogolludo AL, Alonso MJ, Vassallo DV, Pérez-Vizcaino  F, Salaices M. Activation of BKCa channels by nitric oxide prevents coronary rtery endothelial dysfunction in ouabain-induced hypertensive rats. J Hypertens. 2009 Jan;27(1):83-91.

 

Cogolludo A, Moreno L, Frazziano G, Moral-Sanz J, Menendez C, Castañeda J, González C, Villamor E, Perez-Vizcaino F. Activation of neutral sphingomyelinase  is involved in acute hypoxic pulmonary vasoconstriction. Cardiovasc Res. 2009 May 1;82(2):296-302.

 

Lodi F, Jimenez R, Moreno L, Kroon PA, Needs PW, Hughes DA, Santos-Buelga C,  Gonzalez-Paramas A, Cogolludo A, Lopez-Sepulveda R, Duarte J, Perez-Vizcaino F. Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta. Atherosclerosis. 2009 May;204(1):34-9.

 

Bailey L, Moreno L, Manigold T, Krasniqi S, Kropshofer H, Hinton H, Singer T,  Suter L, Hansel TT, Mitchell JA. A simple whole blood bioassay detects cytokine responses to anti-CD28SA and anti-CD52 antibodies. J Pharmacol Toxicol Methods. 2013 Sep-Oct;68(2):231-9.

 

Gatheral T, Reed DM, Moreno L, Gough PJ, Votta BJ, Sehon CA, Rickard DJ, Bertin J, Lim E, Nicholson AG, Mitchell JA. A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses. PLoS One. 2012;7(8):e42386.

 

Moreno L, McMaster SK, Gatheral T, Bailey LK, Harrington LS, Cartwright N, Armstrong PC, Warner TD, Paul-Clark M, Mitchell JA. Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages. Br J Pharmacol. 2010 Aug;160(8):1997-2007.

 

Földes G, Liu A, Badiger R, Paul-Clark M, Moreno L, Lendvai Z, Wright JS, Ali  NN, Harding SE, Mitchell JA. Innate immunity in human embryonic stem cells: comparison with adult human endothelial cells. PLoS One. 2010 May 5;5(5):e10501.

 

Harrington LS, Moreno L, Reed A, Wort SJ, Desvergne B, Garland C, Zhao L,Mitchell JA. The PPARbeta/delta agonist GW0742 relaxes pulmonary vessels andlimits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension. PLoS One. 2010 Mar 4;5(3):e9526.

 

Paul-Clark MJ, McMaster SK, Sorrentino R, Sriskandan S, Bailey LK, Moreno L, Ryffel B, Quesniaux VF, Mitchell JA. Toll-like receptor 2 is essential for the sensing of oxidants during inflammation. Am J Respir Crit Care Med. 2009 Feb 15;179(4):299-306.