Publicaciones científicas en primer decil (D1) de los últimos 5 años

2025

Chronic stress dysregulates autophagy, membrane dynamics, and lysosomal status in frontal cortex and hippocampus of rats
C. Ulecia-Morón, AG. Bris, KS. MacDowell, P. Cerveró-García, JLM. Madrigal, B. García-Bueno, MP. Pereira, JC. Leza, JR Caso
Eur Neuropsychopharmacol. 2025, 94:24-35
10.1016/j.euroneuro.2025.02.005

Metagenomic symphony of the intestinal ecosystem: how the composition affects the mind
Stefanie Malan-Müller, David Martín-Hernández, Javier R. Caso, Jelle Matthijnssens, Amanda Rodriguez-Urrutia, Christopher A. Lowry, Juan C. Leza
Brain Behav Immun. 2025; 123:510-523
10.1016/j.bbi.2024.09.033 39368785

Impact of relapse in BDNF receptors expression in patients with a first episode of schizophrenia
M. Bioque, V. Llorca-Bofí, KS MacDowell, S. Amoretti, G. Mezquida, MJ Cuesta, C. M Diaz-Caneja, Á. Ibáñez, R. Segarra, A. González-Pinto, A. Roldán, PA. Sáiz, A. Mané, A. Lobo, A. Martínez-Pinteño, G. Cano-Escalera, E. Berrocoso, M. Bernardo
Schizophr Bull. 2025 Feb 20:sbaf012
10.1093/schbul/sbaf012 39977257

2024

Intestinal permeability biomarkers in patients with schizophrenia: additional support for the impact of lifestyle habits
González-Blanco L; Dal Santo F; García-Portilla MP; Alfonso M; Hernández C; Sánchez-Autet M; Anmella G; Amoretti S; Sanfont G; Martín-Hernández D; Malan-Müller S; Bernardo M; Arranz B
Eur Psychiatry. 2024 Dec 16;67(1):e84
10.1192/j.eurpsy.2024.1765 39676547

Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions
Fares-Otero NE; Verdolini N; Melero H; Andrés-Camazón P; Vilajosana E; Cavone V; García-Bueno B; Rapado-Castro M; Izquierdo A; Martín-Hernández D; Mola-Cárdenes P; Leal I; Dompablo M; Ortíz-Tallo A; Martínez-Gras I; Muñoz-Sanjose A; Loeck de Lapuerta C; Rodríguez-Jiménez R; Díaz-Marsá M; Bravo-Ortiz MF; Ibáñez A; Baca-García E; Vieta E; Ayuso-Mateos JL; Malpica-González N; Arango C; Díaz-Caneja CM; Radua J.
Psychol Med 2024 Dec 16:1-14
10.1017/S0033291724002393 39679545

The therapeutic use of clonal neural stem cells in experimental Parkinson's disease
A.Nelke, S. García-López, JR. Caso, MP. Pereira
Stem Cell Research & Therapy, 2024; 15:356
10.1186/s13287-024-03965-0 39385216

Probing the oral-brain connection: oral microbiome patterns in a large community cohort with anxiety, depression, and trauma symptoms, and periodontal outcomes
Stefanie Malan-Müller, Rebeca Vidal, Esther O’Shea, Eduardo Montero, Elena Figuero, Iñaki Zorrilla, Javier de Diego-Adeliño, Marta Cano, Maria Paz García-Portilla, Ana González-Pinto, and Juan C. Leza
Transl Psychiatry. 2024 Sep 24
10.1038/s41398-024-03122-4 39368974

Microglial morphological/inflammatoryphenotypes and endocannabinoid signalingin a preclinical model of periodontitisand depression
Robledo-Montaña J, Díaz-García C, Martínez M, Ambrosio N, Montero E, Marín MJ, Virto L, Muñoz-López M, Herrera D, Sanz M, Leza JC, García-Bueno B, Figuero E, Martín-Hernández D
J Neuroinflammation. 2024 Sep 8;21(1):219
10.1186/s12974-024-03213-5 39245706

Decreased oxytocin levels related to social cognition impairment in borderline personality disorder
Galvez-Merlin A, López-Villatoro JM, de la Higuera-González P, de la Torre-Luque A, McDowell K, Díaz-Marsá M, Leza JC, Carrasco JL
Acta Psychiatr Scand. 2024 Jun;149(6):458-466
10.1111/acps.13679 38477064

N-acetylcysteine during critical neurodevelopmental periods prevents behavioral and neurochemical deficits in the Poly I:C rat model of schizophrenia
Diego Romero-Miguel, Marta Casquero-Veiga, Nicolás Lamanna-Rama, Sonia Torres-Sánchez, Karina S MacDowell, José A García-Partida, Cristina Santa-Marta, Esther Berrocoso, Juan C Leza, Manuel Desco, María Luisa Soto-Montenegro
Transl Psychiatry 2024 Jan 8;14(1):14
10.1038/s41398-023-02652-7 38191622

Differential regulation of innate immune system in frontal cortex and hippocampus in a “double-hit” neurodevelopmental model in rats
Álvaro G. Bris, Karina S. MacDowell, Cristina Ulecia-Morón, David Martín-Hernández, Beatriz Moreno, José L.M. Madrigal, Borja García-Bueno, Javier R. Caso, Juan C. Leza
Neurotherapeutics. 2024 Jan;21(1):e00300
10.1016/j.neurot.2023.10.010 38241165

2023

Neuroimaging revealed long-lasting glucose metabolism changes to morphine withdrawal in rats pretreated with the cannabinoid agonist CP-55,940 during periadolescence
N Lamanna-Rama, K S MacDowell, G López, J C Leza, M Desco, E Ambrosio, M L Soto-Montenegro
Eur Neuropsychopharmacol 2023 Apr;69:60-76
10.1016/j.euroneuro.2023.01.005 36780817

Neuroinflammation related to the blood-brain barrier and sphingosine-1-phosphate in a pre-clinical model of periodontal diseases and depression in rats
Martín-Hernández D, Martínez M, Robledo-Montaña J, Muñoz-López M, Virto L, Ambrosio N, Marín MJ, Montero E, Herrera D, Sanz M, Leza JC, Figuero E, García-Bueno B
J Clin Periodontol 2023 Jan 16
10.1111/jcpe.13780 36644813

The gut-microbiota-brain axis in a Spanish population in the aftermath of the COVID-19 pandemic: microbiota composition linked to anxiety, trauma, and depression profiles
Malan-Müller S, Valles-Colomer M, Palomo T, Leza JC
Gut Microbes 2023 Jan-Dec;15(1):2162306
10.1080/19490976.2022.2162306 36651663

Neighborhood Vulnerability and Disability in First Episode of Psychosis: A Multilevel Study
Ana Izquierdo, María Cabello, Itziar Leal, Iosune Torio, José L M Madrigal, Karina S MacDowell, Roberto Rodriguez-Jimenez, David Rentero, Ángela Ibáñez, Miriam Ayora, Covadonga M Díaz-Caneja, Renzo Abregú-Crespo, Blanca Mellor-Marsá, Marina Díaz-Marsá, Norberto Malpica, María-Fé Bravo-Ortiz, Enrique Baca-García, Celso Arango, Jose Luis Ayuso-Mateos; AGES-CM Group
J Clin Psychiatry 2023 Mar 13;84(2):22m14401
10.4088/JCP.22m14401 36920290

2022

Models of microglia depletion and replenishment elicit protective effects to alleviate vascular and neuronal damage in the diabetic murine retina
Church KA, Rodriguez D, Vanegas D, Gutierrez IL, Cardona SM, Madrigal JLM, Kaur T, Cardona AE
J Neuroinflammation. 2022 Dec 14;19(1):300
10.1186/s12974-022-02659-9 36517889

2021

The prefrontal cortex as a target for atypical antipsychotics in schizophrenia, lessons of neurodevelopmental animal models
Tendilla-Beltrán H, Sanchez-Islas NDC, Marina-Ramos M, Leza JC, Flores G
Prog Neurobiol. 2021 Apr;199:101967
10.1016/j.pneurobio.2020.101967 33271238

Periodontal diseases and depression: A pre-clinical in vivo study
Martínez M, Martín-Hernández D, Virto L, MacDowell KS, Montero E, González- Bris Á, Marín MJ, Ambrosio N, Herrera D, Leza JC, Sanz M, García-Bueno B, Figuero E
J Clin Periodontol. 2021 Apr;48(4):503-527
10.1111/jcpe.13420 33432590

Viewpoint | European COVID-19 exit strategy for people with severe mental disorders: Too little, but not yet too late
De Picker LJ, Yolken R, Benedetti F, Borsini A, Branchi I, Fusar-Poli P, Carlos Leza J, Pariante C, Pollak T, Tamouza R, Vai B, Vernon AC, Benros ME, Leboyer M; ECNP Immuno-NeuroPsychiatry TWG
Brain Behav Immun 2021 May;94:15-17
10.1016/j.bbi.2021.01.008 33493625

Severe mental illness and European COVID-19 vaccination strategies
De Picker LJ, Dias MC, Benros ME, Vai B, Branchi I, Benedetti F, Borsini A, Leza JC, Kärkkäinen H, Männikkö M, Pariante CM, Güngör ES, Szczegielniak A, Tamouza R, van der Markt A, Fusar-Poli P, Beezhold J, Leboyer M
Lancet Psychiatry 2021 May;8(5):356-359
10.1016/S2215-0366(21)00046-8 33609450

Kynurenine pathway in post-mortem prefrontal cortex and cerebellum in schizophrenia: relationship with monoamines and symptomatology
Afia AB, Vila È, MacDowell KS, Ormazabal A, Leza JC, Haro JM, Artuch R, Ramos B, García-Bueno B
J Neuroinflammation. 2021 Sep 12;18(1):198
10.1186/s12974-021-02260-6 34511126

2020

Toll-like receptor 4 agonist and antagonist lipopolysaccharides modify innate immune response in rat brain circumventricular organs
Vargas-Caraveo A, Sayd A, Robledo-Montaña J, Caso JR, Madrigal JLM, García- Bueno B, Leza JC
J Neuroinflammation 2020 Jan 6;17(1):6
10.1186/s12974-019-1690-2 31906991