Grupos de investigación

Publicaciones previas a 2016 sobre orbivirus y coronavirus

  • Caballero M, Carabaña J, Ortego J, Fernandez Muñoz R, Celma M.L. Measles virus fusion protein is palmitoylated on transmembrane-intracytoplasmic cysteine residues which participate in cell fusion (1998) J. Virol. 72: 8198-8204.
  • Escors D, Ortego J, Laude H, Enjuanes L. The membrane M protein carboxyterminus binds to transmissible gastroenteritis coronavirus core and contributes to core stability (2001) J. Virol. 75: 1312-1324.
  • Enjuanes L, Sola I, Almazán F, Ortego J. Resistencia a infecciones mediante el diseño de vectores virales bioseguros y la transgénesis. (2001) Eds. España Nuevo Milenio, Madrid
  • Enjuanes L, Sola I, Almazán F, Ortego J, Izeta A, Gonzalez J. M, Alonso S, Sanchez-Morgado J.M, Escors D, Calvo E, Riquelme C, Sanchez C.M. Coronavirus derived expression systems (2001) J. Biotechnol. 88:183-204.
  • Escors D, Ortego J, Enjuanes L. The membrane M protein of the TGEV binds to the internal core through the carboxy-terminus (2001) Adv. Exp. Med. Biol. 494: 589-594.
  • Escors D, Camafeita E, Ortego J, Laude H, Enjuanes L. Organization of two TGEV membrane protein topologies within the virion and core (2001) J. Virol. 75: 12228-12240.
  • Ortego J, Wollmann G, Coca-Prados M. Regulation of gene expression of neurotensin and the neuroendocrine prohormone convertases PC1 and PC2 in the bovine ocular ciliary epithelium (2002) Neurosci Lett. 333: 49-53.
  • Ortego J, Escors D, Laude H, Enjuanes L. Generation of a replication competent propagation deficient virus vector based on the TGEV genome (2002) J. Virol. 76: 11518-11529.
  • Riquelme C, Escors D, Ortego J, Sanchez C.M, Uzelac-Keserovic B, Apostolov K, Enjuanes L. Nature of the virus associated to the endemic Balkan Nephropathy (2002) Emerg. Infect. Dis. 8: 869-870.
  • Kennedy B.N, Li C, Ortego J, Coca-Prados M, Sarthy V.P, Crabb J.W. CRALBP transcriptional regulation in ciliary epithelial, retinal Muller and retinal pigment epithelial cells (2003) Exp. Eye Res. 76: 257-260.
  • Ortego J, Sola I, Almazan F, Ceriani J. E, Riquelme C, Balash M, Plana J, Enjuanes L. Transmissible gastroenteritis coronavirus gene 7 is not essential but influences in vivo virus replication and virulence (2003) Virology 308: 13-22.
  • Enjuanes L,  Almazán F,  Ortego J. Virus based vectors for gene expression in mammalian cells: coronavirus. En: Gene transfer and expression in mammalian cells. Eds. S. C. Makrides. Elsevier Science. Amsterdam. Holanda (2003).
  • Almazán F,  DeDiego M.L,  Galán C,  Escors D,  Alvarez E,  Ortego J,  Sola I,  Zuñiga S,  Alonso S,  Moreno J.L,  Nogales A,  Capiscol C,  Enjuanes L. Construction of a SARS-CoV infectious cDNA clone and a replicon to study coronavirus RNA synthesis (2006) J. Virol. 80: 10900-10906.
  • Ortego J,  Ceriani J.E,  Patiño C,  Plana J,  Enjuanes L. Absence of E protein arrests transmissible gastroenteritis coronavirus maturation in the secretory pathway (2007) Virology 368: 296-308.
  • Enjuanes L,  Sola I,  Zuñiga S,  Ortego J. Expression vectors based on coronavirus genomes (2007) En: Virus Expression Vectors. Transworld Research Network.
  • Brun A, Albina E, Barret T, Chapman DAG, Czub M, Dixon LK, Kei GMl, Klonjkowski B, LePotier M-F, Ortego J, Richardson J, Takamatsu H-H Antigen delivery systems for veterinary vaccine development. Viral-vector based delivery systems (2008) Vaccine 26: 6508-6528.
  • Calvo-Pinilla E, Rodriguez-Calvo T, Anguita J, Sevilla N, Ortego J. Establisment of a bluetongue virus infection model in mice that are deficient in the Alpha/Beta interferon receptor (2009) PLoS ONE. 4(4): e5171.
  • Calvo-Pinilla E, Rodriguez-Calvo T, Anguita J, Sevilla N, Ortego J. Heterologous prime boost vaccination with DNA and recombinant modified vaccinia virus Ankara protects IFNAR(-/-) mice against lethal bluetongue infection (2009) Vaccine 28:437-445.
  • Calvo-Pinilla E, Nieto JM, Ortego J. Experimental oral infection of bluetongue virus serotype 8 in type I interferon receptor-deficient mice (2010) J Gen Virol. 91:2821-2825.
  • Ribes JM, Ortego J, Ceriani J, Montava R, Enjuanes L, Buesa J. Transmissible gastroenteritis virus (TGEV)-based vectors with engineered murine tropism express the rotavirus VP7 protein and immunize mice against rotavirus (2011) Virology 410:107-118.
  • Franceschi V, Capocefalo A, Calvo-Pinilla E, Redaelli M, Mucignat-Caretta C, Mertens P, Ortego J, Donofrio G. Immunization of knock-out α/β interferon receptor mice against lethal bluetongue infection with a BoHV-4-based vector expressing BTV-8 VP2 antigen (2011) Vaccine 29: 3074-3082.
  • Castillo-Olivares J, Calvo-Pinilla E, Casanova I, Bachanek-Bankowska K, Chiam R, Maan S, Nieto JM, Ortego J, Mertens PP. A modified vaccinia Ankara virus (MVA) vaccine expressing African horse sickness virus (AHSV) VP2 protects against AHSV challenge in an IFNAR -/- mouse model (2011) PLoS One 26, 6(1):e16503.
  • Calvo-Pinilla E, Navasa N, Anguita J, Ortego J. Multiserotype protection elicited by a combinatorial prime-boost vaccination strategy against bluetongue virus (2012) PLoS One 7(4): e34735.
  • Jabbar TK, Calvo-Pinilla E, Mateos F, Gubbins S, Bin-Tarif A, Bachanek-Bankowska K, Alpar O, Ortego J, Takamatsu HH, Mertens PP, Castillo-Olivares J. Protection of IFNAR (-/-) mice against bluetongue virus serotype 8, by heterologous (DNA/rMVA) and homologous (rMVA/rMVA) vaccination, expressing outer-capsid protein VP2. (2013) PLoS One 12: 8(4): e60574.
  • de la Poza F, Calvo-Pinilla E, López-Gil E, Marín-López A, Mateos F, Castillo-Olivares J, Lorenzo G, Ortego J. NS1 is a key protein in the vaccine composition to protect IFNAR(-/-) mice against infection with multiple serotypes of African horse sickness virus. (2013) PLoS One 23, 8(7):e70197.
  • Calvo-Pinilla E, de la Poza F, Gubbins S, Mertens P, Ortego J, Castillo-Olivares J. Vaccination of mice with a modified Vaccinia Ankara (MVA) virus expressing the African horse sickness virus (AHSV) capsid protein VP2 induces virus neutralising antibodies that confer protection against AHSV upon passive immunization (2014) Virus Res. 180:23-30.
  • Ortego J, Mertens PP. Bluetongue revisited (2014) Virus Res. 182:1-2.
  • Ortego J, de la Poza F, Marín-López A. Interferon α/β receptor knockout mice as a model to study bluetongue virus infection (2014) Virus Res. 182:35-42.
  • Calvo-Pinilla E, Castillo-Olivares J, Jabbar T, Ortego J, de la Poza F, Marín-López A. Recombinant vaccines against bluetongue virus. (2014) Virus Res. 182:78-86.
  • Marín-López A, Otero-Romero I, de la Poza F, Menaya-Vargas R, Calvo-Pinilla E, Benavente J, Martínez-Costas JM and Ortego J. VP2, VP7, and NS1 proteins of bluetongue virus targeted in avian reovirus muNS-Mi microspheres elicit a protective immune response in IFNAR (-/-) mice (2014) Antiviral Res. 110:42-51.                             
  • Calvo-Pinilla E, de la Poza F, Gubbins S, Mertens PP, Ortego J, Castillo-Olivares J. Antiserum from mice vaccinated with modified vaccinia Ankara virus expressing African horse sickness virus (AHSV) VP2 provides protection when it is administered 48h before, or 48h after challenge (2015) Antiviral Res. 116:27-33.                             
  • Legisa DM, Perez Aguirreburualde MS, Gonzalez FN, Marin-Lopez A, Ruiz V, Wigdorovitz A, Martinez-Escribano JA, Ortego J, Dus Santos MJ. An experimental subunit vaccine based on Bluetongue virus 4 VP2 protein fused to an antigen-presenting cells single chain antibody elicits cellular and humoral immune responses in cattle, guinea pigs and IFNAR(-/-) mice. (2015) Vaccine 33(22):2614-9.               
  • de la Poza F, Marín-López A, Castillo-Olivares J, Calvo-Pinilla E, Ortego J. Identification of CD8 T cell epitopes in VP2 and NS1 proteins of African horse sickness virus in IFNAR(-/-) mice. (2015) Virus Res. 210:149-53.
  • Marín-López A, Ortego J. Generation of Recombinant Modified Vaccinia Virus Ankara Encoding VP2, NS1, and VP7 Proteins of Bluetongue Virus. ( 2016) Vaccine Technologies for Veterinary Viral Diseases. En: Methods in Molecular Biology pp. 137-150 Springer International Publishing