Director:
Dr. Rafael Rotger
Professor [E-mail]
Tel.: +34 - 91 394 2274
Funding:
Ministerio de Educación y Ciencia
Fondo de Investigaciones Sanitarias
Comunidad Autónoma de Madrid
Universidad Complutense de Madrid
Announcements/Research offers
Bacterial colonisation and infection
The mains interest of the group's research activities, which started in 1987, have been the study of the pathogenicity of Salmonella infection. However, other research lines have arisen from collaborations with Hospitals, with the University of San Pablo-CEU, and especially with the Department of Nutrition of this Faculty (Isabel Goñi, Researcher). These lines included antibiotic resistance in Salmonella, dynamics of the colonisation of cystic fibrosis patients by Pseudomonas aeruginosa and effects of the diet on the intestinal microbiota. The group has also participated in the SAFFIC European project, aimed to the proposal of new quality standards for saffron.
The collaboration with the research group directed by Professor María Molina has been very successful in the characterisation of Salmonella effectors by using the yeast cell model. Currently, we have also started the characterisation of Burkholderia cenocepacia virulence factors; this opportunistic pathogen is responsible for an awfully severe syndrome in cystic fibrosis patients.
Last publications
- López-Oliva E, Pozuelo MJ, Rotger R, Muñoz-Martínez E, Goñi I. 2012. Grape antioxidant dietary fibre prevents mitochondrial apoptotic pathways by enhancing Bcl-2 and Bcl-xL expression and minimizing oxidative stress in rat distal colonic mucosa. British Journal of Nutrition, in press(doi: 10.1017/S0007114512000517).
- Pozuelo MJ, Agis-Torres A, Hervert-Hernández D, López-Oliva ME, Muñoz-Martínez E, Rotger R, Goñi I. 2012. Grape antioxidant dietary fibre stimulates Lactobacillus growth in rat caecum. Journal of Food Science, 77: H59-62 (doi:10.1111/j.1750-3841.2011.02520.x).
- Rodríguez-Escudero I, Ferrer N, Rotger R, Cid VJ, Molina M. 2011. Interaction of the Salmonella Typhimurium effector protein SopB with host cell Cdc42 is involved in intracellular replication. Molecular Microbiology, 8: 1220-24 (doi:10.1111/j.1365-2958.2011.07639.x).
- Pozuelo MJ, Jiménez PA, Valderrey AD, Fernández-Olmos A, Cantón R, Rotger R. 2011. Polymorphism of mucA and fpvA genes in Pseudomonas aeruginosa isolates from cystic fibrosis patients: co-existence of genetically different variants. Enferm Infecc Microbiol Clin,29:26-31 (doi:10.1016/j.eimc.2010.05.006)
- Pintado C, de Miguel A, Acevedo A, Nozal L, Novella JL, Rotger R. 2011. Bactericidal effect of saffron (Crocus sativus L.) on Salmonella enterica during storage. Food Control, 22: 638-642 (doi:10.1016/j.foodcont.2010.09.031)
- Valderrey AD, Pozuelo MJ, Jiménez PS, Maciá MD, Oliver A, Rotger R. 2010. Chronic colonization by Pseudomonas aeruginosa of patients with obstructive lung diseases: cystic fibrosis, bronchiectasis and chronic obstructive pulmonary disease. Diagnostic Microbiology and Infectious Disease, 68: 20-7 (doi:10.1016/j.diagmicrobio.2010.04.008).
- Hervert-Hernández D, Pintado C, Rotger R, Goñi I. 2009. Stimulatory role of grape pomace polyphenols on Lactobacillus acidophilus growth. Int. J. Food Microbiol.136: 119–122 (doi: 10.1016/j.ijfoodmicro.2009.09.016).
- Cosano I, Pintado C, Acevedo O, Novella JL, Alonso GL, Carmona M, de la Rosa C, Rotger R. 2009. Microbial quality of saffron from the main producer countries. J. Food Protection 72: 2217–2220.
- Alemán A, Fernández-Piñar P, Pérez-Núñez D, Rotger R, Martín H, Molina M. 2009. A yeast-based genetic screen for identification of pathogenic Salmonella proteins. FEMS Microbiol. Letters 296:167-177 (doi:10.1002/pmic.200800907).
- Molero C, Rodríguez-Escudero I, Alemán A, Rotger R, Molina M, Cid VJ. 2009. Addressing the effects of Salmonella internalization in host cell signaling on a reverse-phase protein array. Proteomics 9:1-14 (doi: 10.1111/j.1574-6968.2009.01630.x).
- Rotger, R. 2008. The Evolution of Salmonella and Salmonella Infections. Chap. 29 (pp. 349-359) in F. Baquero, C. Nombela, G.H. Cassell and J.A. Gutiérrez-Fuentes (Eds.) Evolutionary Biology of Bacterial and Fungal Pathogens. ASM Press, Washington DC.
