The
main research lines of the Biotransformations group are: i) Biocatalysts
preparation; ii) Organic synthesis; iii) Characterization of Natural
Products; iv) Drug delivery; v) Molecular recognition; vi) Polymer
synthesis; vii) Synthesis of drugs and chiral compounds using
immobilized enzyme or whole cells (bacteria, actinomycetes, yeasts,
basidiomycetes or filamentous fungi); viii) Immobilization of
enzyme and whole cells; ix) Resolution of racemic mixtures of
acids, amines, alcohols, esters, etc. using proteases, acylases,
esterases or lipases; x) Stereoselective red-ox process using
whole cells; xi) Chemical synthesis of heterocyclic compounds;
xii) Synthesis of nanostructures with optical and electric properties;
xiii) Screening of microorganisms producing enzymes with interest
in Biotransformations; xiv) White
Biotechnology.
The Biotransformations Group has been recognized by the Regional
Government of Madrid as a "Reference
of Quality". After the first evaluation,
only a few research groups deserved that honor. More information
at Madrid+D web site.
Industrial
Biotransformations Service: The Biotransformations
group participates in the research and technology transfer activities
of Madrid Science Park, a R+D+i foundation belonging to Universidad
Complutense and Universidad Autónoma.
RUNNING
RESEARCH PROJECTS
International
cooperation with Ibero-American Universities
-
FORMACIÓN DE UN GRUPO INTERUNIVERITARIO PARA EL DESARROLLO
SOSTENIBLE DEL ALTIPLANO Y LA AMAZONIA PERUANA. Universidad Complutense
de Madrid. 2009-2011. Prof. Andres. R. ALCÁNTARA
-
ACCIONES DE EDUCACIÓN SANITARIA Y MEDIO AMBIENTAL EN LA
REGIÓN MARGINAL DE FLORENCIA VARELA (Argentina). Universidad
Complutense de Madrid. Proyectos cooperación al desarroll.
2010-2012. Prof. Dr. M. J. HERNAIZ.
Molecular recognition
-
SÍNTESIS QUIMIOENZIMÁTICA DE GLICOCONJUGADOS Y GLICOMIMÉTCOS
Y ESTUDIO DE SU IMPLICACIÓN EN PROCESOS DE RECONOCIMIENTO
MOLECULAR, CTQ2009-11801. MICINN
2009-2012. Prof. Dr. M. J. HERNAIZ.
-
JOSE VICENTE SINISTERRA, ANDRÉS-RAFAEL ALCÁNTARA,
MARCOS ALMENDROS, MARÍA JOSÉ HERNÁIZ, JOSÉ-MARÍA
SANCHEZ-MONTERO, JORGE TRELLES. Enzyme-catalyzed synthesis of
unnatural or modified nucleosides. Wiley Encyclopedia of Industrial
Biotechnology. New York, John Wiley and Sons. 2010.
-
Y. SIMEÓ, SINISTERRA J.V. Biotransformation of Terpenoids:
A Green Alternative for Producing Molecules with Pharmacological
Activity. Mini-Reviews in Organic Chemistry. 2009, 11, 855-862.
-
J.D. CARBALLEIRA, J. FERNANDEZ-LUCAS, M.A. QUEZADA, M.J. HERNAIZ,
A.R. ALCANTARA, Y. SIMEO, J.V. SINISTERRA. Biotransformations.
Encyclopedia of Microbiology 3rd Edition. M. Schaechter, Ed.,
vol. 1, pp. 212-251, Oxford: Elsevier [view].
-
P.HOYOS, P. DOMINGUEZ de MARIA, A. ALCANTARA and J.V. SINISTERRA.
Hydrolase-Based Synthesis of Enantiopure alpha-Hydroxy Ketones:
From Racemic Resolutions to Chemo-Enzymatic Dynamic Kinetic Resolutions.
Biotechnology: Research, Technology and Applications. 2008. .
-
PÉREZ-VILLAR S, RUBIO, J., OTEO J.L. Study of colour and
structural changes in silver painted medieval glasses. J. Non-Crystalline
Solids. 2008, 354, 1833-1844.
-
TAMAYO A., PEÑA-ALONSO R., RUBIO J., RUBIO F., OTEO J.L.
Gradient Pore Size Distributions in Porous Silicon Oxycarbide
Materials: J. Eur. Ceram. Soc. 2008, 28, 1871–1879.
-
L.A. CONDEZO, J. FERNANDEZ-LUCAS, C.A. GARCIA-BURGOS, A. R. ALCANTARA,
J.V. SINSITERRA. Enzymatic synthesis of modified nucleosides.
Review. In Biocatalysis in the Pharmaceutical & Biotechnology
Industries, Patel R.N. Ed. CRC Press. pp 401-423, 2007.
-
L. TÉLLEZ, M.A. VALENZUELA, J. RUBIO, , F. RUBIO, J. L. OTEO.
Pore structure and texture of organic/inorganic hybrid materials.
In.- Mechanical Properties and Performance of Engineering Ceramics
and Composites II, Edited by Rajan Tandon, Volume 27, editors
Andrew Wereszczak and Edgar Lara-Curzio, Wiley & Sons, U.S.A.
Vol. 27, 2, 387-397, 2007. ISBN 0196-6219.
-
M. NUS, F. FRANCES, J. LIBRELOTTO, A. CANALES, D. CORELLA, J M.
SANCHEZ-MONTERO, F. J. SANCHEZ-MUÑIZ- Arylesterase Activity Depend
on PON1-Q192R and PON1-55 Polymorphisms in Subjects at Increased
Risk of Cardiovascular Disease Consuming Walnut-Enriched Meat.
J. Nutrition 2007, 137, 1783-1788.
-
A. CANALES, J. BENEDÍ, M. NUS, J. LIBRELOTTO, J.M. SÁNCHEZ-MONTERO,
F. SANCHEZ-MUÑIZ.- Effect of Walnut-Enriched Restructured Meat
in the Antioxidant Status of Overweight / Obese Senior Subjects
with at Least One Extra CHD- Risk Factor. J. Am. Coll. Nutr. 2007,
26(3):225-32.
-
D. ROMANO, V. FERRARIO, F. MOLINARI, L. GARDOSSI, J.M. SANCHEZ-MONTERO,
P. TORRE, A. CONVERTI. Kinetic resolution of (R, S)-1,2-O-isopropylideneglycerol
by esterification with dry mycelia of moulds. Journal of Molecular
Catalysis B: Enzymatic, 41, 3-4, 71-74.
DOI
-
L.CONDEZO, J. FERNANDEZ-LUCAS, C.A. GARCIA-BURGOS, A. ALCANTARA,
J.V. SINISTERRA. Enzymatic Synthesis of Modified Nucleosides.
Chapter 14 inBiocatalysts in the Pharmaceutical and Biotechnology
Industries. Editor R. Patel. 2006.
-
M. NUS, F. SÁNCHEZ-MUÑIZ, J.M. SÁNCHEZ-MONTERO. Methodological
Aspects and Relevance of the Study of Vegetable Oil, Fat and Lipoprotein
Oxidation Using Pancreatic Lipase and Arylesterase. Review Article.
Food Technology and Biotechnology, 2006, 44, 1, 1-16.
-
J.D. CARBALLEIRA, E. ALVAREZ, J.V. SINISTERRA. 3D-QSAR/CoMFA models
as a tool for Biocatalysis and Protein Engineering. Chemical and
Biochemical Engineering Quarterly. 2006. 20, 2, 155-163.
-
P. DOMÍNGUEZ de MARÍA, A. ALCANTARA, J.D. CARBALLEIRA, C. GARCIA-BURGOS,
M.J. HERNAIZ, J.M. SANCHEZ-MONTERO, J.V. SINISTERRA. Candida
rugosa lipase: A traditional and complex biocatalyst. Review
Article. Current Organic Chemistry, 2006, 10(10) 1053-1066.
-
A.M. RODRIGUEZ BAYON, M.E. FRANCO GIL. Relationship between rheological
properties and emulsion stability. Association de Pharmacie Galénique
Industrielle, 90, Octubre 2006.
- A.M. RODRIGUEZ BAYON, A.M. ARIZA OSORIO. Influence of the diffusion
cell in the “in vitro” percutaneous penetration studies.
Association de Pharmacie Galénique Industrielle, 146, October
2006.
-
J.D. CARBALLEIRA, E. ALVAREZ E., M.A. QUEZADA, C.A. GARCIA-BURGOS,
J.V. SINISTERRA. Novel microorganisms for the stereoselective
oxidation of alcohols. In "Microorganisms for Industrial
Enzymes and Biocontrol". 2005. ISBN: 81-308-0040-3. Editors
E. Mellado and J. L. Barredo. Research Signpost.
- RODRIGUEZ-BAYON A.M., ANDRES V., DENTI E. Influencia de la naturaleza
del emulgente en la cesión del componente activo de formas semisólidas
tópicas. Acción Médica. 2005,145-148
-
A. ALCANTARA, P. DOMINGUEZ de MARIA, M. FERNANDEZ, M.J. HERNAIZ,
J.M. SANCHEZ MONTERO AND J.V. SINISTERRA. Resolution of Racemic
Acids, Esters and Amines by Candida rugosa Lipase in
Slightly Hydrated Organic Media. Food Technology and Biotechnology,
2004, 42, 343-354.
-
J.A. TRELLES, E. LEWKOWICZ, J.V. SINISTERRA, A.M. IRIBARREN. Free
and immobilised Citrobacter amalonaticus CECT 863 as
a biocatalyst for nucleoside synthesis. International Journal
of Biotechnology. 2004, 6, 4, 376-384.
- M.J. HERNAIZ GÓMEZ-DÉGANO; M. PEREZ; J.V. SINISTERRA.
Process for regio-selective manufacture of disaccharide or oligosaccharides.
European patent EP: 08011388. COGNIS S.A. 2008.
- R. DE REGIL, A. RODRIGUEZ BAYON; J.V. SINISTERRA. Process for
the manufacture of acyclovir pro-drugs. European patent EP: 080193253.
COGNIS S.A. 2008.
Grupo
de Biotransformaciones.
Departamento de Química Orgánica y Farmacéutica. Facultad de
Farmacia. Universidad Complutense de Madrid. Plaza de Ramón
y Cajal s/n. 28040 Madrid. Tel. +34 91 394 18 20. Fax. +34 91
394 18 22.
RUNNING
RESEARCH PROJECTS
International
cooperation with Ibero-American Universities
