RESEARCH LINES
   
New Reactivity and Mechanistic Studies in Transition Metal Compounds  

Our contribution in this area is mainly focused on the chemistry of Fischer type carbene complexes. We are interested in:

  • Transmetallation Processes
  • Photochemistry
  • Cycloadditions
  • New C-C bond forming reactions
Selected Publications: Acc. Chem. Res. 2005, 38, 44; J. Am. Chem. Soc. 2003, 125, 9572; Angew. Chem. Int. Ed. 2006, 45, 125; Chem. Eur. J. 2005, 11, 5988; Chem. Eur. J. 2003, 9, 4943; Chem. Eur. J.  2008, 14, 11222; J. Am. Chem. Soc. 2008, 130, 13892; Chem. Comm. 2008, 4671; Inorg. Chem. 2008, 47, 5253; Org. Lett.  2008, 10, 365; Chem. Eur. J.  2009, 15, 593; Organometallics 2009, 28, 956.
     
Electron Transfer in conventional and non-conventional media  
We have reported the first example of the reaction between an heterogeneous ET reagent and a metal carbene complex and the evidence of ET processes in non-conventional media (ESI source). In this context, we have also coined the terms electron sources and electron-sinks. We have also studied the mechanisms of the ET processes in the ESI source by means of selective deuteration experiments . The results obtained have risen new concepts in the study and understanding of ET processes in conventional and non-conventional media.
Selected Publications: Angew. Chem. Int. Ed. 2002, 41, 3442; J. Mass Spect. 2003, 38, 151; Organometallics 2004, 23, 4647; J. Org. Chem. 2005, 70, 5269; Chem. Eur, J. 2007, 13, 736; Organometallics 2009, 28, 2762.
     
Synthesis of Natural Product-Based Bio-Organometallic Hybrids  

We have synthesized hybrid compounds based on natural products, within the Diversity Oriented Synthesis (DOS) approach. The implementation of synthetic methodologies as the Nicholas reaction, the cross-metathesis or the Cu catalysed azide-alkyne cycloaddition, to complex natural products, have delivered new bio-organometallic entities having fascinating structures and interesting properties.

In addition, we are using reversible reactions and bond- directed methodologies to efficiently build macrocyclic organometallic hybrids trough a covalent self-assembling process. Complex and structurally diverse molecular entities may be accessed a la carte, with imagination as the sole frontier.
Selected Publications: Chem. Eur. J. 2005, 11, 3659; Org. Lett. 2006, 8, 593; Chem. Eur. J. 2006, 12, 6403; Chem. Comm. 2006, 985; J. Org. Chem. 2007, 72, 4213; Org. Lett.  2008, 10, 3555; Chem. Eur. J. 2009,15, 6940; Dalton Trans. 2009,8399; Chem. Eur. J. 2010,16, 1592.
     
Development of new chelating agents and study of the mechanism of transfer of iron to plants  
We have developed methodology to synthesize different types of chelating agents that can be used as efficient iron chlorosis correctors. Additionally, we are studying the mechanism of transfer of iron to plants, a process in which the enzyme Fe-chelate redutase is playing a key role.
Selected Publications: J. Agric. Food Chem. 2002, 50, 6395; Inorg. Chem. 2003, 42, 5412; Chem. Eur. J. 2005, 11, 5997; Inorg. Chem. 2006, 45, 5321; J. Agric. Food Chem. 2009, 57, 5143
     
Design and Synthesis of New Energetic Materials  
     
See: Research Funds